Results 51 to 60 of about 19,866 (162)

Modeling rod and cone photoreceptor cell survival in vivo using optical coherence tomography

Scientific Reports, 2023
Many retinal diseases involve the loss of light-sensing photoreceptor cells (rods and cones) over time. The severity and distribution of photoreceptor loss varies widely across diseases and affected individuals, so characterizing the degree and pattern ...
S. Scott Whitmore, Adam P. DeLuca, Jeaneen L. Andorf, Justine L. Cheng, Mahsaw Mansoor, Christopher R. Fortenbach, D. Brice Critser, Jonathan F. Russell, Edwin M. Stone, Ian C. Han   +9 more
doaj   +1 more source

Developing a simple method to enhance the generation of cone and rod photoreceptors in pluripotent stem cell-derived retinal organoids [PDF]

Stem Cells, 2019
Abstract Cell replacement therapy is a promising treatment for irreversible retinal cell death in diverse diseases such as Stargardt's disease, age-related macular degeneration, and retinitis pigmentosa. The final impact of all retinal dystrophies is the loss of photoreceptors; hence, there is a pressing need for research into ...
Zerti D., Dorgau B., Felemban M., Ghareeb A. E., Yu M., Yuchun D., Krasnogor N., Lako M.   +7 more
openaire   +3 more sources

Transplantation of photoreceptor and total neural retina preserves cone function in P23H rhodopsin transgenic rat. [PDF]

PLoS ONE, 2010
BACKGROUND: Transplantation as a therapeutic strategy for inherited retinal degeneration has been historically viewed to restore vision as a method by replacing the lost retinal cells and attempting to reconstruct the neural circuitry with stem cells ...
Ying Yang, Saddek Mohand-Said, Thierry Léveillard, Valérie Fontaine, Manuel Simonutti, José-Alain Sahel   +5 more
doaj   +1 more source

Disturbed retinoid metabolism upon loss of rlbp1a impairs cone function and leads to subretinal lipid deposits and photoreceptor degeneration in the zebrafish retina

eLife, 2021
The RLBP1 gene encodes the 36 kDa cellular retinaldehyde-binding protein, CRALBP, a soluble retinoid carrier, in the visual cycle of the eyes. Mutations in RLBP1 are associated with recessively inherited clinical phenotypes, including Bothnia dystrophy ...
Domino K Schlegel, Srinivasagan Ramkumar, Johannes von Lintig, Stephan CF Neuhauss   +3 more
doaj   +1 more source

Prion-induced photoreceptor degeneration begins with misfolded prion protein accumulation in cones at two distinct sites: cilia and ribbon synapses

Acta Neuropathologica Communications, 2021
Accumulation of misfolded host proteins is central to neuropathogenesis of numerous human brain diseases including prion and prion-like diseases. Neurons of retina are also affected by these diseases.
James F. Striebel, Brent Race, Jacqueline M. Leung, Cindi Schwartz, Bruce Chesebro   +4 more
doaj   +1 more source

Amyloid precursor protein is required for normal function of the rod and cone pathways in the mouse retina. [PDF]

PLoS ONE, 2012
Amyloid precursor protein (APP) is a transmembrane glycoprotein frequently studied for its role in Alzheimer's disease. Our recent study in APP knockout (KO) mice identified an important role for APP in modulating normal neuronal development in the ...
Tracy Ho, Kirstan A Vessey, Roberto Cappai, Virginie Dinet, Frédéric Mascarelli, Giuseppe D Ciccotosto, Erica L Fletcher   +6 more
doaj   +1 more source

Retinal degeneration in cone photoreceptor cell-ablated transgenic mice.

Molecular vision, 2000
To examine the effect of loss of cone photoreceptor cells on retinal degeneration.We previously identified a cone photoreceptor cell-specific promoter of human cone transducin a-subunit (GNAT2) gene. In this report, a minigene, Trc-Tox176, that contains the GNAT2 promoter, an attenuated diphtheria toxin A-chain gene, and an enhancer element from human ...
S, Ying, H T, Jansen, M N, Lehman, S L, Fong, W W, Kao   +4 more
openaire   +1 more source

A transgenic mice model of retinopathy of cblG-type inherited disorder of one-carbon metabolism highlights epigenome-wide alterations related to cone photoreceptor cells development and retinal metabolism

Clinical Epigenetics, 2023
AbstractBackgroundMTRgene encodes the cytoplasmic enzyme methionine synthase, which plays a pivotal role in the methionine cycle of one-carbon metabolism. This cycle holds a significant importance in generating S-adenosylmethionine (SAM) and S-adenosylhomocysteine (SAH), the respective universal methyl donor and end-product of epigenetic ...
Karim Matmat, Jean-Baptiste Conart, Paul-Henri Graindorge, Sandra El Kouche, Ziad Hassan, Youssef Siblini, Rémy Umoret, Ramia Safar, Okan Baspinar, Aurélie Robert, Jean-Marc Alberto, Abderrahim Oussalah, David Coelho, Jean-Louis Guéant, Rosa-Maria Guéant-Rodriguez   +14 more
openaire   +3 more sources

Additional file 1 of cGMP-grade human iPSC-derived retinal photoreceptor precursor cells rescue cone photoreceptor damage in non-human primates

, 2021
Additional file 1: Table S1: List of primary antibodies used in the study. figure S1: Estimation of GFP expression by FACS. After lentivirus infection, 95% of the RPC cells expressed GFP (left panel). There was no GFP in the non-infection control (right panel). figure S2: Controls for GFP, SC121 and AMA staining.
Lingam, Swathi, Liu, Zengping, Yang, Binxia, Wong, Wendy, Parikh, Bhav Harshad, Ong, Jun Yi, Goh, Debbie, Wong, Daniel Soo Lin, Tan, Queenie Shu Woon, Tan, Gavin S. W., Holder, Graham E., Regha, Kakkad, Barathi, Veluchamy Amutha, Hunziker, Walter, Lingam, Gopal, Zeng, Xianmin, Su, Xinyi   +16 more
openaire   +1 more source

Rod and cone photoreceptor cells produce ROS in response to stress in a live retinal explant system

Molecular vision, 2010
peer ...
Bhatt, Lavinia, Groeger, Gillian, McDermott, Kieran W., Cotter, Thomas G.   +3 more
openaire   +3 more sources