Results 61 to 70 of about 19,866 (162)

Müller cell outgrowth after retinal detachment: association with cone photoreceptors.

Investigative ophthalmology & visual science, 2000
Subretinal gliosis is a relatively common occurrence after retinal reattachment. Because Müller cell processes only intermittently penetrate the outer limiting membrane (OLM) beneath extensive detachments, this study was conducted to determine whether this was preferentially associated with rod or cone photoreceptors.Cat retinas were detached from the ...
G P, Lewis, S K, Fisher
openaire   +1 more source

Quantitative and Topographical Analysis of the Losses of Cone Photoreceptors and Retinal Ganglion Cells Under Taurine Depletion

Investigative Opthalmology & Visual Science, 2016
Taurine depletion is known to induce photoreceptor degeneration and was recently found to also trigger retinal ganglion cell (RGC) loss similar to the retinal toxicity of vigabatrin. Our objective was to study the topographical loss of RGCs and cone photoreceptors, with a distinction between the two cone types (S- and L- cones) in an animal model of ...
Hadj-Saïd, W, Froger, N, Ivkovic, I, Jiménez-López, M, Dubus, É, Dégardin-Chicaud, J, Simonutti, M, Quénol, C, Neveux, N, Villegas-Pérez, MP, Agudo-Barriuso, M, Vidal-Sanz, M, Sahel, J-A, Picaud, S, García-Ayuso, D   +14 more
openaire   +3 more sources

Differences in calcium homeostasis between retinal rod and cone photoreceptors revealed by the effects of voltage on the cGMP-gated conductance in intact cells. [PDF]

The Journal of general physiology, 1994
We measured currents under voltage clamp in intact retinal rod photoreceptors with tight seal electrodes in the perforated patch mode. In the dark, membrane depolarization to voltages > or = +20 mV activates a time- and voltage-dependent outward current in the outer segment.
J L, Miller, J I, Korenbrot
openaire   +2 more sources

Microfluidic processing of stem cells for autologous cell replacement

Stem Cells Translational Medicine, 2021
Autologous photoreceptor cell replacement is one of the most promising approaches currently under development for the treatment of inherited retinal degenerative blindness.
Nicholas E. Stone, Andrew P. Voigt, Robert F. Mullins, Todd Sulchek, Budd A. Tucker   +4 more
doaj   +1 more source

Transplanted Donor- or Stem Cell-Derived Cone Photoreceptors Can Both Integrate and Undergo Material Transfer in an Environment-Dependent Manner

Stem Cell Reports, 2018
Summary: Human vision relies heavily upon cone photoreceptors, and their loss results in permanent visual impairment. Transplantation of healthy photoreceptors can restore visual function in models of inherited blindness, a process previously understood ...
Paul V. Waldron, Fabiana Di Marco, Kamil Kruczek, Joana Ribeiro, Anna B. Graca, Claire Hippert, Nozie D. Aghaizu, Aikaterini A. Kalargyrou, Amanda C. Barber, Giulia Grimaldi, Yanai Duran, Samuel J.I. Blackford, Magdalena Kloc, Debbie Goh, Eduardo Zabala Aldunate, Robert D. Sampson, James W.B. Bainbridge, Alexander J. Smith, Anai Gonzalez-Cordero, Jane C. Sowden, Robin R. Ali, Rachael A. Pearson   +21 more
doaj   +1 more source

Retinal Phenotype in the rd9 Mutant Mouse, a Model of X-Linked RP

Frontiers in Neuroscience, 2019
Retinal degeneration 9 (rd9) mice carry a mutation in the retina specific “Retinitis Pigmentosa GTPase Regulator (RPGR)” Open Reading Frame (ORF) 15 gene, located on the X chromosome and represent a rare model of X-linked Retinitis Pigmentosa (XLRP), a ...
Antonio Falasconi, Antonio Falasconi, Martina Biagioni, Elena Novelli, Ilaria Piano, Claudia Gargini, Enrica Strettoi   +6 more
doaj   +1 more source

Assessment of photoreceptor recovery and visual function utilizing adaptive optics and microperimetry in patients with surgically closed macular holes

Photodiagnosis and Photodynamic Therapy
Background: This study investigated the association between photoreceptor structural restoration and visual function outcomes in patients undergoing surgery for closed macular holes (MHs).
Yuanyuan Liu, Xueli Yang, Wei Zhou, Jinguo Yu, Song Chen, Tiangeng He, Caiyun You, Xiangda Meng, Mengyu Liao, Yi Lei, Hua Yan   +10 more
doaj   +1 more source

NR2E3 loss disrupts photoreceptor cell maturation and fate in human organoid models of retinal development

The Journal of Clinical Investigation
While dysfunction and death of light-detecting photoreceptor cells underlie most inherited retinal dystrophies, knowledge of the species-specific details of human rod and cone photoreceptor cell development remains limited.
Nathaniel K. Mullin, Laura R. Bohrer, Andrew P. Voigt, Lola P. Lozano, Allison T. Wright, Vera L. Bonilha, Robert F. Mullins, Edwin M. Stone, Budd A. Tucker   +8 more
doaj   +1 more source

Drosophila photoreceptor tethering by a laminin-Eys scaffold

iScience
Summary: Visual acuity in Drosophila requires precise photoreceptor alignment along the optical axis, maintained by longitudinal tension between a rigid cornea and a contractile retinal base. Here, we identify the rhabdomere caps—an extracellular matrix (
Donald F. Ready, Henry C. Chang
doaj   +1 more source

Non-linearities in the Rod and Cone Photoreceptor Inputs to the Afferent Pupil Light Response

Frontiers in Neurology, 2018
Purpose: To assess the nature and extent of non-linear processes in pupil responses using rod- and cone-isolating visual beat stimuli.Methods: A four-primary photostimulating method based on the principle of silent substitution was implemented to ...
Pablo Alejandro Barrionuevo, J. Jason McAnany, Andrew J. Zele, Dingcai Cao   +3 more
doaj   +1 more source