Results 91 to 100 of about 640,739 (357)

Eye Drop with Fas-Blocking Peptide Attenuates Age-Related Macular Degeneration

Cells
Age-related macular degeneration (AMD), characterized by macular retinal degeneration, poses a significant health concern due to the lack of effective treatments for prevalent dry AMD.
Yujong Yi, Seon-Hong Pyun, Chae-Yeon Kim, Gyeongju Yun, Eunhwa Kang, Seoyoun Heo, Irfan Ullah, Sang-Kyung Lee   +7 more
doaj   +1 more source

An experimental pig model with outer retinal degeneration induced by temporary intravitreal loading of N-methyl-N-nitrosourea during vitrectomy

Scientific Reports, 2021
We aimed to develop an outer retinal degeneration pig model induced by temporary intravitreal loading of N-methyl-N-nitrosourea (MNU) during vitrectomy. In a preliminary experiment involving 5 mini-pig cases to determine the appropriate concentration of ...
Kwang-Eon Choi, Vu Thi Que Anh, Jee Taek Kim, Cheolmin Yun, Seongkwang Cha, Jungryul Ahn, Yong Sook Goo, Seong-Woo Kim   +7 more
doaj   +1 more source

Post‐Translational Modifications in Cilia and Ciliopathies

Advanced Science, EarlyView.
This review synthesizes current understanding of post‐translational modifications (PTMs) in ciliary proteins and emphasizes their roles in ciliary formation, homeostasis, and signaling. This review also discusses the implication of PTM dysregulation in ciliopathies and explores therapeutic strategies targeting PTM‐modifying enzymes.
Jie Ran, Jun Zhou
wiley   +1 more source

Magnetic‐Guided Delivery of Antisense Oligonucleotides for Targeted Transduction in Multiple Retinal Explant and Organoid Models

Advanced Science, EarlyView.
Magnetic field‐guided MNP@ATR‐ASO nanocomplexes facilitate the targeted delivery of ASOs to ganglion cells or photoreceptors within retinal explants, thereby enhancing the efficacy of ASOs in correcting pre‐mRNA splicing abnormalities. Furthermore, the nanocomplexes improve ASO penetration and delivery in human retinal and inner ear organoid models ...
Xiuhong Ye, Sihui Chen, Wei Xiong, Fan Wang, Hon Fai Chan, Haocheng Lai, Xiangyu Guo, Tingting Yang, Shuhao Shen, Hang Chen, Wenxuan Wang, Guei‐Sheung Liu, Yonglong Guo, Jiansu Chen   +13 more
wiley   +1 more source

Assessment of Deep Generative Models for High-Resolution Synthetic Retinal Image Generation of Age-Related Macular Degeneration

JAMA ophthalmology, 2019
Importance Deep learning (DL) used for discriminative tasks in ophthalmology, such as diagnosing diabetic retinopathy or age-related macular degeneration (AMD), requires large image data sets graded by human experts to train deep convolutional neural ...
P. Burlina, P. Burlina, Neil J. Joshi, Katia D. Pacheco, T. Y. A. Liu, N. Bressler   +5 more
semanticscholar   +1 more source

Generation of Neural Organoids and Their Application in Disease Modeling and Regenerative Medicine

Advanced Science, EarlyView.
Neural organoids provide a versatile platform for neurological research. Advances in organoid technology have partially achieved human neural tissue complexity in terms of tissue structure, cell diversity, and neural signaling, offering insights into neural disorders and regenerative strategies. Technology advances from biomaterials, bio‐manufacturing,
Ruiqi Huang, Feng Gao, Liqun Yu, Haokun Chen, Rongrong Zhu   +4 more
wiley   +1 more source

Late-Onset Retinal Degeneration: Clinical Perspectives

Clinical Ophthalmology, 2022
Leonardo Lando,1,2 Shyamanga Borooah1 1Shiley Eye Institute, University of California San Diego, La Jolla, CA, USA; 2Department of Ophthalmology and Vision Sciences, University of Toronto, Toronto, ON, CanadaCorrespondence: Shyamanga Borooah, Shiley Eye ...
Lando L, Borooah S
doaj  

Ceramide Signaling in Retinal Degeneration [PDF]

, 2011
Retinal degenerations (RD) are a complex heterogeneous group of diseases in which retinal photoreceptors and the supporting retinal pigment epithelial cells die irreversibly, causing visual loss for millions of people. Mutations on more than 150 genes have been discovered for RD and there are many forms that possess complex etiology involving more than
Richard S. Brush, Nawajes A. Mandal, Abul K. Rahman, Haidong Yang, Julie-Thu A. Tran, Kelly Ahern, Anisse Saadi, Michael T. Matthes, Douglas Yasumura, Man Yu, Matthew M. LaVail, Hui Chen, Hui Chen   +12 more
openaire   +3 more sources

Reconstructing Three‐Dimensional Optical Anisotropy with Tomographic Müller‐Polarimetric Microscopy

Advanced Science, EarlyView.
Tomographic Müller polarimetric microscopy is a novel imaging technique that resolves 3D birefringent properties of bulky samples, unveiling hierarchical nanostructures at microscopic resolution. Based on incoherent visible‐light polarimetry, it achieves experimental simplicity by eliminating phase measurements.
Yang Chen, Arthur Baroni, Torne Tänzer, Leonard Nielsen, Marianne Liebi   +4 more
wiley   +1 more source

NLRP3 inflammasome activation drives bystander cone photoreceptor cell death in a P23H rhodopsin model of retinal degeneration.

Human Molecular Genetics, 2016
The molecular signaling leading to cell death in hereditary neurological diseases such as retinal degeneration is incompletely understood. Previous neuroprotective studies have focused on apoptotic pathways; however, incomplete suppression of cell death ...
Ishaq A. Viringipurampeer, Andrew Metcalfe, A. Bashar, Olena Sivak, Anat Yanai, Zeinabsadat Mohammadi, O. L. Moritz, C. Gregory‐Evans, K. Gregory-Evans   +8 more
semanticscholar   +1 more source