Results 211 to 220 of about 640,739 (357)

Recessive NRL mutations in patients with clumped pigmentary retinal degeneration and relative preservation of blue cone function [PDF]

, 2004
Koji M. Nishiguchi, James S. Friedman, Michael A. Sandberg, Anand Swaroop, Eliot L. Berson, Thaddeus P. Dryja   +5 more
openalex   +1 more source

Editorial: Novel therapeutic strategies for retinal degeneration. [PDF]

Front Ophthalmol (Lausanne)
Soliño M, López-Costa JJ, Martínez A.
europepmc   +1 more source

Activated mTOR Signaling in the RPE Drives EMT, Autophagy, and Metabolic Disruption, Resulting in AMD‐Like Pathology in Mice

Aging Cell, EarlyView.
Our study reveals that overactivation of both mTOR complexes through mLST8 in RPE cells triggers AMD‐like pathology and cellular dysfunction. This finding highlights the critical role of balanced mTOR signaling in retinal health and suggests that targeting both complexes could be therapeutic for AMD treatment.
Olivia Chowdhury, Sridhar Bammidi, Pooja Gautam, Vishnu Suresh Babu, Haitao Liu, Peng Shang, Ying Xin, Emma Mahally, Mihir Nemani, Victoria Koontz, Kira Lathrop, Katarzyna M. Kedziora, Jonathan Franks, Ming Sun, Joshua W. Smith, Lauren R. DeVine, Robert N. Cole, Nadezda Stepicheva, Anastasia Strizhakova, Sreya Chattopadhyay, Stacey Hose, Jacob Samuel Zigler Jr., José‐Alain Sahel, Jiang Qian, Prasun Guha, James T. Handa, Sayan Ghosh, Debasish Sinha   +27 more
wiley   +1 more source

The fellow eye of patients with phakic rhegmatogenous retinal detachment from atrophic holes of lattice degeneration without posterior vitreous detachment [PDF]

, 2004
C R Gonzales
openalex   +1 more source

Correction: Inhibition of microRNA-155 Protects Retinal Function Through Attenuation of Inflammation in Retinal Degeneration. [PDF]

Mol Neurobiol
Aggio-Bruce R, Chu-Tan JA, Wooff Y, Cioanca AV, Schumann U, Natoli R.   +5 more
europepmc   +1 more source

BRD4/MAP2K7/PGF Signaling Axis Promotes Senescence and Extracellular Matrix Metabolism of Nucleus Pulposus Cells in Intervertebral Disk Degeneration

Aging Cell, EarlyView.
This study identifies BRD4 as a key regulator in intervertebral disk degeneration (IDD), linking its upregulation to NP cell senescence and disrupted ECM metabolism through the BRD4/MAP2K7/PGF signaling cascade, offering a potential therapeutic target for IDD treatment.
Guangzhi Zhang, Lei Li, Zhili Yang, Zhenyu Cao, Xuchang Hu, Yonggang Wang, Xuewen Kang   +6 more
wiley   +1 more source

Optimal discrimination of an Abyssinian cat recessive retinal degeneration: a short electroretinogram protocol is more efficient than a long one [PDF]

, 2004
Vaegan, Kristina Narfström
openalex   +1 more source

Moss-derived human complement factor H modulates retinal immune response and attenuates retinal degeneration. [PDF]

J Neuroinflammation
Hector M, Behnke V, Dabrowska-Schlepp P, Busch A, Schaaf A, Langmann T, Wolf A.   +6 more
europepmc   +1 more source

Pyrroloquinoline Quinone Reprograms the Single‐Cell Landscape of Immune Aging in Hematopoietic Immune System

Aging Cell, EarlyView.
This study demonstrates that aging induces oxidative stress and inflammation in the hematopoietic immune system, resulting in immune homeostasis dysfunction, including alterations in B cells and hematopoietic stem cells, senescent cells (SnCs) accumulation, and senescence‐associated secretory phenotypes (SASPs) production. Notably, the study highlights
Xiuxing Liu, Chun Zhang, Jianjie Lv, Yidan Liu, Chenyang Gu, Yuehan Gao, Wen Ding, Hui Chen, Nanwei Xu, Hongbin Yin, Wenru Su, Zhuping Xu   +11 more
wiley   +1 more source

ABCA4-Associated Retinal Degenerations Spare Structure and Function of the Human Parapapillary Retina [PDF]

, 2005
Artur V. Cideciyan, Małgorzata Świder, Tomas S. Alemán, Alexander Sumaroka, Sharon Schwartz, Marisa I. Román, Ann H. Milam, Jean Bennett, Edwin M. Stone, Samuel G. Jacobson   +9 more
openalex   +1 more source