Results 211 to 220 of about 110,459 (310)

Transcriptional regulation of human NMNAT2: insights from 3D genome sequencing and bioinformatics

The FEBS Journal, EarlyView.
NMNAT2 is a valuable drug target, as low levels increase the risk of neurodegeneration. We employed 4C‐seq to identify NMNAT2 regulatory regions in the human genome, revealing distinct interactomes of the NMNAT2 promoter in undifferentiated and neuron‐like SH‐SY5Y cells. Additionally, we uncovered NMNAT2‐associated genes and transcription factors. This
Yu Chen Chang, Sen Yang, Minyoung Cho, Kwangsik Nho, José‐Manuel Baizabal, Hui‐Chen Lu   +5 more
wiley   +1 more source

Aggregation of the Constitutively Active K296E Rhodopsin Mutant Contributes to Retinal Degeneration. [PDF]

FASEB J
Vasudevan S, Prakash V, Park PS.
europepmc   +1 more source

Melatonin and the Dental Pulp: A Scoping Review

International Endodontic Journal, EarlyView.
ABSTRACT Background In general medicine, melatonin is known to enhance wound healing and promote stem cell differentiation. Its potential relevance in endodontics, however, remains underexplored. Objectives This scoping review aimed to systematically assess the available evidence on the effects of melatonin (a) on dental pulp tissue and (b) on human ...
Jasmin Schäfer, Konrad Kleszczynski, Edgar Schäfer   +2 more
wiley   +1 more source

Histopathologic and ultrastructural features of the choriocapillaris in dogs with sudden acquired retinal degeneration syndrome and progressive retinal atrophy. [PDF]

Vet Pathol
Heyward JL, Dubielzig RR, Ray C, Teixeira LBC, Mowat FM.   +4 more
europepmc   +1 more source

Forced exercise modulates retinal inflammatory response and regulates miRNA expression to promote retinal neuroprotection during degeneration [PDF]

H Haupt, V Chen, Teele Palumaa, T.T. Anderson, Gabriela Sanchez Rodriguez, Joshua A. Chu‐Tan, Riccardo Natoli, Andrew Feola, John M. Nickerson, Machelle T. Pardue, Jeffrey H. Boatright, Katie L. Bales   +11 more
openalex   +1 more source

Erythrocyte deformability correlates with microvascular ischemia and disease severity in diabetic retinopathy

Journal of Diabetes Investigation, EarlyView.
Under physiological conditions, deformable erythrocytes pass smoothly through the capillary network, maintaining retinal capillary perfusion (A). In pathological conditions, reduced erythrocyte deformability causes irregular passage and stagnation within capillaries, resulting in localized blood flow stasis and microvascular congestion, leading to ...
Ye Eun Han, Joon Seo Lim, Yulim Kim, Inhye Kim, Jun Sung Moon, Junyeop Lee   +5 more
wiley   +1 more source

Molecular insights into electroreceptor ribbon synapses from differential gene expression in sturgeon lateral line organs

Journal of Anatomy, EarlyView.
The expression of various genes involved in synapse development, stability and/or function was studied in developing mechanosensory neuromasts and electrosensory ampullary organs in sterlet sturgeon. Most were shared, including Slc17a8, Slc1a3 and Nrxn3, but Cbln18 was neuromast‐restricted and Tulp1 was ampullary organ‐restricted.
Alexander S. Campbell, Martin Minařík, David Buckley, Tanmay Anand, David Gela, Martin Pšenička, Clare V. H. Baker   +6 more
wiley   +1 more source

Neural modulation of ocular immunity: Exploring a sympathetic‐macrophage neuroimmune link in the human ciliary body

Journal of Anatomy, EarlyView.
Using microscopy and 3D confocal imaging on seven cadaveric eyes, we identified sympathetic nerves closely associated with β₂‐adrenergic receptor‐expressing macrophages in the human ciliary body (CB). These findings suggest a sympathetic‐macrophage neuroimmune link in the CB, potentially influencing ocular inflammation and degeneration, warranting ...
Tanya S. Karakyriakou, Claire Mackaaij, Mark van Zijverden, Hendrik A. Messal, Jeannette Ossewaarde‐van Norel, Ronald L. A. W. Bleys, Cindy G. J. Cleypool   +6 more
wiley   +1 more source

Oral 8-aminoguanine against age-related retinal degeneration. [PDF]

Commun Biol
Vats A, Xi Y, Wolf-Johnston AS, Clinger OD, Arbuckle RK, Sheng L, Jiang X, Dermond CD, Li J, Stolz DB, St Leger AJ, Sahel JA, Jackson EK, Birder LA, Chen Y.   +14 more
europepmc   +1 more source

Independent Effects of Blood Pressure on Intraocular Pressure and Retinal Ganglion Cell Degeneration: A Mendelian Randomization Study [PDF]

Skanda Rajasundaram, Ayellet V. Segrè, Dipender Gill, Benjamin Woolf, Seyedeh M. Zekavat, Stephen Burgess, Anthony P. Khawaja, Nazlee Zebardast, Janey L. Wiggs   +8 more
openalex   +1 more source