Results 231 to 240 of about 640,739 (357)

DLK/JNK3 Upregulation Aggravates Hair Cell Senescence in Mice Cochleae via Excessive Autophagy

Aging Cell, EarlyView.
In normal physiological processes, autophagy acts as a protective factor against aging stress. With the stress increase, the DLK/JNK3 pathway is activated and autophagy is continuously upregulated. In our study, excessive autophagy leads to hair cell senescence, which reveals that excessive autophagy can play a harmful role in senescence under certain ...
Rui Ding, Weiyi Huang, Chenling Shen, Yi Pan, Yiming Zhong, Bing Kong, Yilin Shen, Mingliang Xiang, Bin Ye   +8 more
wiley   +1 more source

Polyglutamine-expanded ataxin-7 inhibits STAGA histone acetyltransferase activity to produce retinal degeneration [PDF]

, 2005
Vikas B. Palhan, Shiming Chen, Guang-Hua Peng, Agneta Tjernberg, Armin M. Gamper, Yuxin Fan, Brian T. Chait, Albert R. La Spada, Robert G. Roeder   +8 more
openalex   +1 more source

Long-term restoration of visual function in end-stage retinal degeneration using subretinal human melanopsin gene therapy

Proceedings of the National Academy of Sciences of the United States of America, 2017
S. D. De Silva, A. Barnard, S. Hughes, S. K. Tam, Chris Martin, Mandeep S. Singh, Alona Barnea-Cramer, M. McClements, M. During, S. Peirson, M. Hankins, R. MacLaren   +11 more
semanticscholar   +1 more source

Nicotinamide Riboside Mitigates Retinal Degeneration by Suppressing Damaged DNA-Stimulated Microglial Activation and STING-Mediated Pyroptosis. [PDF]

Invest Ophthalmol Vis Sci
Zhu S, Zhang L, Tong P, Chen J, Wang C, Wang Z, Liu J, Duan P, Jiang Q, Zhou Y, Tan G, Zhang X, Jiang B.   +12 more
europepmc   +1 more source

Wound, pressure ulcer, and burn guidelines (2023)―4: Guidelines for the management of connective tissue disease/vasculitis‐associated skin ulcers, third edition

The Journal of Dermatology, EarlyView.
Yoshihide Asano, Jun Asai, Takayuki Ishii, Yohei Iwata, Masanari Kodera, Chie Miyabe, Akihiko Uchiyama, Youichi Ogawa, Ken Okamura, Mari Kishibe, Yuta Koike, Yorihisa Kotobuki, Noriki Fujimoto, Takuya Miyagi, Yukie Yamaguchi, Ayumi Yoshizaki, Reiko Omori, Takeshi Nakanishi, Hiroshi Fujiwara, Takeo Maekawa, Sei‐ichiro Motegi, Yuichiro Yoshino, Minoru Hasegawa, Manabu Fujimoto, Takao Tachibana, Wound, Pressure Ulcer, and Burn Guidelines Drafting Committee (connective tissue disease/vasculitis group)   +27 more
wiley   +1 more source

Ythdf2 Ablation Protects Aged Retina From RGC Dendrite Shrinking and Visual Decline

Aging Cell, EarlyView.
The m6A reader YTHDF2 regulates retinal degeneration caused by aging, which is mediated by its target mRNAs Hspa12a and Islr2. ABSTRACT Aging‐related retinal degeneration and vision loss have been severely affecting the elderly worldwide. Previously, we showed that the m6A reader YTHDF2 is a negative regulator for dendrite development and protection of
Fugui Niu, Gaoxin Long, Jian Zhang, Jun Yu, Sheng‐Jian Ji   +4 more
wiley   +1 more source

Ibuprofen reduces inflammation, necroptosis and protects photoreceptors from light-induced retinal degeneration. [PDF]

J Neuroinflammation
Zhang PW, Wan ZH, Li W, Vats A, Mehta K, Fan L, Zhou L, Li S, Li G, Keuthan CJ, Berlinicke C, Qian C, Esumi N, Duh EJ, Zack DJ.   +14 more
europepmc   +1 more source

Human asthenozoospermia: Update on genetic causes, patient management, and clinical strategies

Andrology, EarlyView.
Abstract Background In mammals, sperm fertilization potential relies on efficient progression within the female genital tract to reach and fertilize the oocyte. This fundamental property is supported by the flagellum, an evolutionarily conserved organelle, which contains dynein motor proteins that provide the mechanical force for sperm propulsion and ...
Emma Cavarocchi, Maëva Drouault, Joao C. Ribeiro, Violaine Simon, Marjorie Whitfield, Aminata Touré   +5 more
wiley   +1 more source

N-Methyl-N-nitrosourea-induced Retinal Degeneration in Animals

, 2003
Airo Tsubura, Katsuhiko Yoshizawa, Katsuji Kiuchi, Kaei Moriguchi   +3 more
openalex   +2 more sources

Molecular composition of drusen and possible involvement of anti‐retinal autoimmunity in two different forms of macular degeneration in cynomolgus monkey ( Macaca fascicularis ) [PDF]

, 2005

openalex   +1 more source