Results 1 to 10 of about 355 (50)

Evaluation of the microperimetry in eyes with cuticular drusen

Scientific Reports, 2022
Retinal sensitivity may vary by subtypes of cuticular drusen. This retrospective study included 52 eyes of 32 patients with cuticular drusen. All the patients underwent assessment of best-corrected visual acuity (BCVA), spectral-domain optical coherence ...
Seung Wan Nam, Jung Hwa Lee, Zeeyoon Byun, Don-Il Ham, Mingui Kong   +4 more
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Increased retinal drusen in IgA glomerulonephritis are further evidence for complement activation in disease pathogenesis

Scientific Reports, 2022
Drusen are retinal deposits comprising cell debris, immune material and complement that are characteristic of macular degeneration but also found in glomerulonephritis.
P. Harraka, Tony Wightman, Sarah Akom, Kieran Sandhu, Deb Colville, Andrew Catran, David Langsford, Timothy Pianta, David Barit, Frank Ierino, Alison Skene, Heather Mack, Judy Savige   +12 more
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Retinal drusen in glomerulonephritis with or without immune deposits suggest systemic complement activation in disease pathogenesis

Scientific Reports, 2022
Retinal drusen are characteristic of macular degeneration and complement activation, but also occur in C3, lupus and IgA nephropathy. This cross-sectional observational study compared drusen counts in different forms of glomerulonephritis.
P. Harraka, H. Mack, D. Colville, D. Barit, D. Langsford, T. Pianta, F. Ierino, Judy Savige   +7 more
doaj   +1 more source

Epithelial phenotype restoring drugs suppress macular degeneration phenotypes in an iPSC model

Nature Communications, 2021
Age-related macular degeneration is characterized by lipid-rich drusen deposits underneath the retinal pigment epithelium (RPE). Here the authors report an in vitro iPSC-RPE model for AMD that recapitulates drusen and RPE atrophy, and identify two drugs ...
Ruchi Sharma, Aman George, Malika Nimmagadda, Davide Ortolan, Barbosa-Sabanero Karla, Zoya Qureshy, Devika Bose, Roba Dejene, Genqing Liang, Qin Wan, Justin Chang, Balendu Shekhar Jha, Omar Memon, Kiyoharu Joshua Miyagishima, Aaron Rising, Madhu Lal, Eric Hanson, Rebecca King, Mercedes Maria Campos, Marc Ferrer, Juan Amaral, David McGaughey, Kapil Bharti   +22 more
doaj   +1 more source

Retinal drusen counts are increased in inflammatory bowel disease, and with longer disease duration, more complications and associated IgA glomerulonephritis

Scientific Reports, 2022
Retinal drusen are deposits of inflammatory proteins that are found in macular degeneration and glomerulonephritis and result, in part, from complement activation.
E. Nicklason, Y. Ham, D. Ng, S. Glance, K. Abel, P. Harraka, H. Mack, D. Colville, J. Savige   +8 more
doaj   +1 more source

Presumed Bietti crystalline dystrophy with optic nerve head drusen: a case report

Journal of Medical Case Reports, 2022
Background Bietti crystalline dystrophy is primarily a retinal dystrophy caused by a CYP4V2 mutation and typically presents with crystalline retinal deposits in the posterior fundus.
Fatemeh Bazvand, Esmaeil Asadi Khameneh
doaj   +1 more source

Retinal findings in membranoproliferative glomerulonephritis

American Journal of Ophthalmology Case Reports, 2017
Purpose: To assess the evolution of retinal findings in patients with membranoproliferative glomerulonephritis (MPGN) by funduscopy, intravenous fluorescein angiography and optical coherence tomography. Observations: Three women and one man were followed
Ahmad M. Mansour, Luiz H. Lima, J. Fernando Arevalo, Miguel Hage Amaro, Virginia Lozano, Alaa Bou Ghannam, Errol W. Chan   +6 more
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Drusen-like beneath retinal deposits in type II mesangiocapillary glomerulonephritis: a review

Revista Brasileira de Oftalmologia, 2015
The aim of this paper is to do a review of Drusen-like beneath retinal deposits in type II mesangiocapillary glomerulonephritis. Drusenlike beneath retinal deposits in type II mesangiocapillary glomerulonephritis appear to develop at an early age, often ...
Miguel Hage Amaro, Cristina Muccioli, Mario Martins do Santos Motta, Jorge Mitre, João Jorge Nassaralla, Luiz Augusto Siqueira Silva, Teruo Aihara   +6 more
doaj   +1 more source

Drusen Segmentation From Retinal Images via Supervised Feature Learning

IEEE Access, 2018
This paper presents a supervised feature learning method to learn discriminative and compact descriptors for drusen segmentation from retinal images.
Xiuxiu Ren, Yuanjie Zheng, Yanna Zhao, Chao Luo, Hong Wang, Jian Lian, Yunlong He   +6 more
doaj   +1 more source

Retinal pigment epithelium-specific CLIC4 mutant is a mouse model of dry age-related macular degeneration

Nature Communications, 2022
Age-related macular degeneration (AMD) is a leading cause of blindness and is characterised by the accumulation of lipid deposits, called drusen. Here, the authors show that mice lacking chloride intracellular channel 4 in retinal pigment epithelium have
Jen-Zen Chuang, Nan Yang, Nobuyuki Nakajima, Wataru Otsu, Cheng Fu, Howard Hua Yang, Maxwell Ping Lee, Armaan Fazal Akbar, Tudor Constantin Badea, Ziqi Guo, Afnan Nuruzzaman, Kuo-Shun Hsu, Joshua L. Dunaief, Ching-Hwa Sung   +13 more
doaj   +1 more source