Increased retinal drusen in IgA glomerulonephritis are further evidence for complement activation in disease pathogenesis [PDF]
Scientific Reports, 2022 Drusen are retinal deposits comprising cell debris, immune material and complement that are characteristic of macular degeneration but also found in glomerulonephritis.
P. Harraka +12 more
doaj +2 more sources
Retinal drusen in glomerulonephritis with or without immune deposits suggest systemic complement activation in disease pathogenesis [PDF]
Scientific Reports, 2022 Retinal drusen are characteristic of macular degeneration and complement activation, but also occur in C3, lupus and IgA nephropathy. This cross-sectional observational study compared drusen counts in different forms of glomerulonephritis.
P. Harraka +7 more
doaj +2 more sources
Retinal drusen counts are increased in inflammatory bowel disease, and with longer disease duration, more complications and associated IgA glomerulonephritis [PDF]
Scientific Reports, 2022 Retinal drusen are deposits of inflammatory proteins that are found in macular degeneration and glomerulonephritis and result, in part, from complement activation.
E. Nicklason +8 more
doaj +2 more sources
Retinal Angiomatous Proliferation in an Eye with Cuticular Drusen [PDF]
Case Reports in Ophthalmology, 2015 Purpose: To report the presence of retinal angiomatous proliferation (RAP) in an eye with cuticular drusen detected by fluorescein and indocyanine green angiography by confocal scanning laser ophthalmoscopy and by spectral-domain optical coherence ...
Atsuko Sato +3 more
doaj +3 more sources
Overproduction of 42 Amino Acids Long Amyloid Beta Leads to Activation of Secretory Autophagy and Development of Drusen‐Like Structures Originating From Retinal Pigment Epithelium [PDF]
The FASEB Journal, Volume 40, Issue 5, 15 March 2026.The role of 42 amino acids long amyloid beta (Aβ) in the retinal pigment epithelium (RPE) was investigated using 5xFAD mice model overproducing Aβ. The RPE cells of 5xFAD mice showed increased oxidative stress, accumulation of autophagy‐destined proteins, increased expression of secretory autophagy markers, and increase in epithelial‐to‐mesenchymal ...
Johanna Ruuth +7 more
wiley +2 more sources
Large drusen following long-standing retinal detachment
Indian Journal of Pathology and Microbiology, 2010 We report an interesting finding of multiple large drusen in an eviscerated eye with a longstanding retinal detachment. The origin and composition of the drusen is also speculated on the basis of special stains.
Shenoy Sandhya +2 more
doaj +3 more sources
Large drusen in long-standing retinal detachment
Oman Journal of Ophthalmology, 2018 Drusen are seen as an end result of various biochemical insults to the retina and have been described in various clinical settings. We would like to report the histopathology of a case of large drusen, seen associated with chronic retinal detachment in a
Rajiv Raman +3 more
doaj +3 more sources
Radiomic Characterization and Automated Classification of Drusen Substructure Phenotype Associated with High-Risk Dry Age-Related Macular Degeneration [PDF]
DiagnosticsBackground/Objectives: Optical coherence tomography (OCT)-reflective drusen substructures (ODSs) are associated with the conversion of intermediate AMD to geographic atrophy (GA). However, ODSs must be manually identified, a laborious process introducing
Scott W. Perkins +6 more
doaj +2 more sources
Evaluation of the microperimetry in eyes with cuticular drusen
Scientific Reports, 2022 Retinal sensitivity may vary by subtypes of cuticular drusen. This retrospective study included 52 eyes of 32 patients with cuticular drusen. All the patients underwent assessment of best-corrected visual acuity (BCVA), spectral-domain optical coherence ...
Seung Wan Nam +4 more
doaj +1 more source
The Epidemiology of Retinal Reticular Drusen [PDF]
American Journal of Ophthalmology, 2008 To describe the prevalence and 15-year cumulative incidence of and risk factors for reticular drusen.Population-based prospective study.Four thousand nine hundred and twenty-six persons, 43 to 86 years of age, were included between 1988 and 1990, of whom 3,684, 2,764, and 2,119 participated in five-, 10-, and 15-year follow-up examinations ...
Ronald, Klein +4 more
openaire +2 more sources