Heritability of retinal drusen in the Copenhagen Twin Cohort Eye Study. [PDF]
Acta Ophthalmol, 2022 To study age‐ and sex‐adjusted heritability of small hard drusen and early age‐related macular degeneration (AMD) in a population‐based twin cohort.
Belmouhand M +7 more
europepmc +2 more sources
Characterization of Retinal Drusen in Subjects at High Genetic Risk of Developing Sporadic Alzheimer's Disease: An Exploratory Analysis. [PDF]
J Pers Med, 2022 Having a family history (FH+) of Alzheimer’s disease (AD) and being a carrier of at least one ɛ4 allele of the ApoE gene are two of the main risk factors for the development of AD.
López-Cuenca I +12 more
europepmc +2 more sources
Visual Function and Macular Carotenoid Changes in Eyes with Retinal Drusen-An Open Label Randomized Controlled Trial to Compare a Micronized Lipid-Based Carotenoid Liquid Supplementation and AREDS-2 Formula. [PDF]
Nutrients, 2020 Purpose: To compare the changes in visual and ocular parameters in individuals with retinal drusen who were treated with two commercially available nutritional supplements.
Davey PG +5 more
europepmc +2 more sources
Calcified nodules in retinal drusen are associated with disease progression in age-related macular degeneration. [PDF]
Sci Transl Med, 2018 Hydroxyapatite nodules in retinal drusen may indicate risk for progression to advanced age-related macular degeneration. Imaging AMD progression Age-related macular degeneration (AMD) is the leading cause of vision impairment in older individuals.
Tan ACS +14 more
europepmc +2 more sources
Multimodal imaging of small hard retinal drusen in young healthy adults. [PDF]
Br J Ophthalmol, 2018 Background Small hard macular drusen can be observed in the retina of adults as young as 18 years of age. Here, we seek to describe the in vivo topography and geometry of these drusen.
Pedersen HR +5 more
europepmc +2 more sources
Multiclass segmentation as multitask learning for drusen segmentation in retinal optical coherence tomography [PDF]
arXiv, 2019 Automated drusen segmentation in retinal optical coherence tomography (OCT) scans is relevant for understanding age-related macular degeneration (AMD) risk and progression. This task is usually performed by segmenting the top/bottom anatomical interfaces that define drusen, the outer boundary of the retinal pigment epithelium (OBRPE) and the Bruch's ...
Rhona Asgari +6 more
arxiv +3 more sources
Journal of Extracellular Vesicles, 2021 Age‐related macular degeneration (AMD) is a leading cause of blindness worldwide. Drusen are key contributors to the etiology of AMD and the ability to modulate drusen biogenesis could lead to therapeutic strategies to slow or halt AMD progression.
Miguel Flores‐Bellver +17 more
doaj +2 more sources
Scientific Reports, 2023 Drusen are an important biomarker for age-related macular degeneration (AMD). Their accurate segmentation based on optical coherence tomography (OCT) is therefore relevant to the detection, staging, and treatment of disease. Since manual OCT segmentation
Olivier Morelle +3 more
doaj +2 more sources
Nonperfused Retinal Capillaries-A New Method Developed on OCT and OCTA. [PDF]
Invest Ophthalmol Vis SciTo develop a new method to quantify nonperfused retinal capillaries (NPCs) by using co-registered optical coherence tomography (OCT) and OCT angiography (OCTA), and to evaluate NPCs in eyes with age-related macular degeneration (AMD) and diabetic retinopathy (DR). Multiple consecutive 3x3-mm OCT/OCTA scans were obtained using a commercial device (Solix;
Gao M +8 more
europepmc +2 more sources
Eye, 2023 Objectives To evaluate the quantitative impact of drusen and hyperreflective foci (HRF) volumes on mesopic retinal sensitivity in non-exudative age-related macular degeneration (AMD).
G. Reiter +6 more
semanticscholar +1 more source