Results 41 to 50 of about 11,541 (214)

Retinal pigment epithelium-specific CLIC4 mutant is a mouse model of dry age-related macular degeneration

Nature Communications, 2022
Age-related macular degeneration (AMD) is a leading cause of blindness and is characterised by the accumulation of lipid deposits, called drusen. Here, the authors show that mice lacking chloride intracellular channel 4 in retinal pigment epithelium have
Jen-Zen Chuang, Nan Yang, Nobuyuki Nakajima, Wataru Otsu, Cheng Fu, Howard Hua Yang, Maxwell Ping Lee, Armaan Fazal Akbar, Tudor Constantin Badea, Ziqi Guo, Afnan Nuruzzaman, Kuo-Shun Hsu, Joshua L. Dunaief, Ching-Hwa Sung   +13 more
doaj   +1 more source

Abundant lipid and protein components of drusen. [PDF]

PLoS ONE, 2010
Drusen are extracellular lesions characteristic of aging and age-related maculopathy, a major retinal disease of the elderly. We determined the relative proportions of lipids and proteins in drusen capped with retinal pigment epithelium (RPE) and in RPE ...
Lan Wang, Mark E Clark, David K Crossman, Kyoko Kojima, Jeffrey D Messinger, James A Mobley, Christine A Curcio   +6 more
doaj   +1 more source

Aquaporin-1 Expression in Retinal Pigment Epithelial Cells Overlying Retinal Drusen

Ophthalmic Research, 2016
<b><i>Purpose:</i></b> In the outer retina, age-related macular degeneration (AMD) results in reduced hydraulic conductivity in Bruch's membrane, possibly leading to altered water transport in retinal pigment epithelial (RPE) cells.
Tran, Thuy Linh, Bek, Toke, Dornonville de la Cour, Morten, Prause, Jan Ulrik, Hamann, Steffen, Heegaard, Steffen   +5 more
openaire   +4 more sources

An in silico model of retinal cholesterol dynamics (RCD model): insights into the pathophysiology of dry AMD

Journal of Lipid Research, 2017
We developed an in silico mathematical model of retinal cholesterol (Ch) dynamics (RCD) to quantify the physiological rate of Ch turnover in the rod outer segment (ROS), the lipoprotein transport mechanisms by which Ch enters and leaves the outer retina,
Seyedeh Maryam Zekavat, James Lu, Cyrille Maugeais, Norman A. Mazer   +3 more
doaj   +1 more source

Developing an image-based grading scale for peripheral drusen to investigate associations of peripheral drusen type with age-related macular degeneration

Scientific Reports
Age-related macular degeneration (AMD) is a leading cause of blindness. It is associated with peripheral drusen which has not been categorized. We investigated peripheral drusen to validate an image grading system and to understand possible associations ...
Paripoorna Sharma, Fritz Gerald P. Kalaw, Andrew Lin, Evan H. Walker, Shyamanga Borooah   +4 more
doaj   +1 more source

Secretory autophagy and epithelial‐to‐mesenchymal transition in cadaveric AMD samples: Novel pathways in disease progression

Acta Ophthalmologica, EarlyView.
Abstract Purpose To examine the presence of secretory autophagy and epithelial–mesenchymal transition (EMT) in the macular retinal pigment epithelium (RPE) of human cadaver eyes with different forms of age‐related macular degeneration (AMD). Methods Human cadaver macula samples representing dry and wet AMD, as well as age‐matched controls, were ...
Iswariyaraja Sridevi Gurubaran, Ali Koskela, Hanna Heloterä, Kai Kaarniranta   +3 more
wiley   +1 more source

Radial optic neurotomy as a treatment for anterior ischemic optic neuropathy secondary to optic disc drusen

GMS Ophthalmology Cases, 2014
[english] Importance: Radial optic neurotomy (RON) was first described by Opremcak as a treatment for patients with central retinal vein occlusion (CRVO).
Pinxten, Isabel, Stalmans, Peter
doaj   +1 more source

Extracellular vesicles released by human retinal pigment epithelium mediate increased polarised secretion of drusen proteins in response to AMD stressors

Journal of Extracellular Vesicles, 2021
Age‐related macular degeneration (AMD) is a leading cause of blindness worldwide. Drusen are key contributors to the etiology of AMD and the ability to modulate drusen biogenesis could lead to therapeutic strategies to slow or halt AMD progression.
Miguel Flores‐Bellver, Jason Mighty, Silvia Aparicio‐Domingo, Kang V. Li, Cui Shi, Jing Zhou, Hannah Cobb, Patrick McGrath, German Michelis, Patricia Lenhart, Ganna Bilousova, Søren Heissel, Michael J. Rudy, Christina Coughlan, Andrew E. Goodspeed, S. Patricia Becerra, Stephen Redenti, M. Valeria Canto‐Soler   +17 more
doaj   +1 more source

Power and clinical utility of mesopic microperimetry analysis strategies in age‐related macular degeneration

Acta Ophthalmologica, EarlyView.
Abstract Purpose This study evaluates whether mesopic microperimetry (MMP) provides a more robust measure of retinal function compared to visual acuity (VA) in age‐related macular degeneration (AMD) clinical trials, with a focus on optimal analysis strategies. Method Fellow‐eyes of unilateral neovascular AMD were prospectively studied.
Francesco Cinque, Jeroen Pas, Mahfam Shahabi, Laurens Sluijterman, Sofie ten Brink, Anita de Breuk, Thomas J. Heesterbeek, Caroline Klaver, Carel Hoyng, Yara Lechanteur   +9 more
wiley   +1 more source

Drusen Disappearance After Retinal Detachment Repair

Journal of VitreoRetinal Diseases
Purpose: To describe a case of a drusenoid pigment epithelial detachment that resolved after retinal detachment (RD) repair using multimodal imaging. Methods: A single case was evaluated. Results: An 83-year-old woman with intermediate age-related macular degeneration had repair of a rhegmatogenous RD with subsequent resolution of macular drusen and ...
Ishrat Ahmed, David M. Wu
openaire   +3 more sources