Results 51 to 60 of about 11,541 (214)

Computational modeling of retinal hypoxia and photoreceptor degeneration in patients with age-related macular degeneration.

PLoS ONE, 2019
Although drusen have long been acknowledged as a primary hallmark of dry age-related macular degeneration (AMD) their role in the disease remains unclear.
Kevin J McHugh, Dian Li, Jay C Wang, Leon Kwark, Jessica Loo, Venkata Macha, Sina Farsiu, Leo A Kim, Magali Saint-Geniez   +8 more
doaj   +1 more source

A Case of a Young Asymptomatic Woman with Optic Disc Drusen and Vasculitis

Case Reports in Ophthalmology, 2011
Purpose: We present the case of a young woman with optic disc drusen and peripheral vasculitis. Methods: Diagnosis was based on fundoscopic, optical coherence tomography as well as fluorescein angiography (FA) findings.
Tryfon Rotsos, Chrysanthos Symeonidis, Mrinal Rana, James S. Deane   +3 more
doaj   +1 more source

Neovascular age‐related macular degeneration without drusen

Acta Ophthalmologica, EarlyView.
Abstract Purpose To describe the clinical characteristics and 1‐year follow‐up of patients with neovascular AMD (nAMD) without drusen in either eye. Methods This is a multicentre retrospective cohort study in three tertiary referral centres in The Netherlands. We included patients of 55 years or older with nAMD in one or both eyes, without the presence
Marc J. Sirks, Elon H. C. van Dijk, Husein Ghalayini, Somayeh Bazdar, WeiFeng Yu, Suzanne Yzer, José P. Martinez Ciriano, Reinier O. Schlingemann, Roselie M. H. Diederen, Camiel J. F. Boon   +9 more
wiley   +1 more source

Generation of iPSCs (RFSCi007-A, RFSCi008-A) from a patient with early-onset bilateral drusen and a healthy sibling for retinal disease modeling

Stem Cell Research
Drusen are extracellular deposits between the retinal pigment epithelium and Bruch’s membrane, commonly linked to age-related macular degeneration (AMD).
Sonali Singh, Wendy Runyon, Sam Hu, Paige Grona Kennedy, Ajeet Singh, Rinki Ratnapriya, Ritu Kumar, Karl Csaky, Srinivasa R. Sripathi   +8 more
doaj   +1 more source

Characterization of retinal pigment epithelium layer in healthy and diseased retinas with high‐resolution adaptive optics transscleral flood illumination imaging

Acta Ophthalmologica, EarlyView.
Abstract Purpose The retinal pigment epithelium (RPE) is critical in the pathophysiology of retinal diseases, such as age‐related macular degeneration. Adaptive optics transscleral flood illumination (AO‐TFI) offers rapid, detailed morphometric characterization of the RPE layer.
Leila Sara Eppenberger, Safa Mohanna, Sohrab Ferdowsi, Sonja Simon‐Zoula, Oliver Pfäffli, Christoph Amstutz, Lucas M. Bachmann, Michael A. Thiel, Martin K. Schmid   +8 more
wiley   +1 more source

The prechoroidal cleft in neovascular age‐related macular degeneration

Acta Ophthalmologica, EarlyView.
Abstract The prechoroidal cleft is a lenticular, hypo‐reflective space on optical coherence tomography imaging, located between a band of fibrovascular material underneath the retinal pigment epithelium (RPE) and Bruch's membrane. It occurs in 8%–22% of neovascular age‐related macular degeneration (nAMD) eyes, most often with macular neovascularization
Niels J. Brouwer, T. H. Khanh Vu, Yvonne De Jong‐Hesse, Elon H. C. van Dijk   +3 more
wiley   +1 more source

Significance of Hyperreflective Foci as an Optical Coherence Tomography Biomarker in Retinal Diseases: Characterization and Clinical Implications

Journal of Ophthalmology, 2021
Hyperreflective foci (HRF) is a term coined to depict hyperreflective dots or roundish lesions within retinal layers visualized through optical coherence tomography (OCT).
Serena Fragiotta, Solmaz Abdolrahimzadeh, Rosa Dolz-Marco, Yoichi Sakurada, Orly Gal-Or, Gianluca Scuderi   +5 more
doaj   +1 more source

OCT Based Interpretation of the Optic Nerve Head Anatomy and Prevalence of Optic Disc Drusen in Patients with Idiopathic Intracranial Hypertension (IIH)

Life, 2021
We aimed to systematically examine the optic nerve head anatomy in patients with idiopathic intracranial hypertension (IIH) using a standardized optical coherence tomography (OCT) protocol.
Elisabeth Arnberg Wibroe, Lasse Malmqvist, Steffen Hamann   +2 more
doaj   +1 more source

Deep Learning‐Based Detection of Reticular Pseudodrusen in Age‐Related Macular Degeneration

Clinical &Experimental Ophthalmology, EarlyView.
ABSTRACT Background Reticular pseudodrusen (RPD) signify a critical phenotype driving vision loss in age‐related macular degeneration (AMD). This study sought to develop and externally test a deep learning (DL) model to detect RPD on optical coherence tomography (OCT) scans with expert‐level performance.
Himeesh Kumar, Yelena Bagdasarova, Scott Song, Doron G. Hickey, Amy C. Cohn, Mali Okada, Robert P. Finger, Jan H. Terheyden, Ruth E. Hogg, Pierre‐Henry Gabrielle, Louis Arnould, Maxime Jannaud, Xavier Hadoux, Peter van Wijngaarden, Carla J. Abbott, Lauren A. B. Hodgson, Roy Schwartz, Adnan Tufail, Emily Y. Chew, Cecilia S. Lee, Erica L. Fletcher, Melanie Bahlo, Brendan R. E. Ansell, Alice Pébay, Robyn H. Guymer, Aaron Y. Lee, Zhichao Wu   +26 more
wiley   +1 more source

Laser photocoagulation of soft macular drusen

Офтальмохирургия, 2013
Purpose. The assessment of morphological and functional results of the threshold photocoagulation in eyes with large soft macular drusen. Material and methods. Thirty four patients (39 eyes) were enrolled in the study.
L.I. Balashevich, M.V. Gatsu, M.V. Gordeyeva   +2 more
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