Results 141 to 150 of about 119,076 (326)

Transcriptional regulation of human NMNAT2: insights from 3D genome sequencing and bioinformatics

The FEBS Journal, EarlyView.
NMNAT2 is a valuable drug target, as low levels increase the risk of neurodegeneration. We employed 4C‐seq to identify NMNAT2 regulatory regions in the human genome, revealing distinct interactomes of the NMNAT2 promoter in undifferentiated and neuron‐like SH‐SY5Y cells. Additionally, we uncovered NMNAT2‐associated genes and transcription factors. This
Yu Chen Chang, Sen Yang, Minyoung Cho, Kwangsik Nho, José‐Manuel Baizabal, Hui‐Chen Lu   +5 more
wiley   +1 more source

Oral nicotinamide provides robust, dose-dependent structural and metabolic neuroprotection of retinal ganglion cells in experimental glaucoma

Acta Neuropathologica Communications
A compromised capacity to maintain NAD pools is recognized as a key underlying pathophysiological feature of neurodegenerative diseases. NAD acts as a substrate in major cell functions including mitochondrial homeostasis, cell signalling, axonal ...
Gloria Cimaglia, James R. Tribble, Marcela Votruba, Pete A. Williams, James E. Morgan   +4 more
doaj   +1 more source

Exosome-Mediated Delivery of the Neuroprotective Peptide PACAP38 Promotes Retinal Ganglion Cell Survival and Axon Regeneration in Rats With Traumatic Optic Neuropathy

, 2021
Tian Wang, Yiming Li, Miao Guo, Xue Dong, Mengyu Liao, Mei Du, Xiaohong Wang, HaiFang Yin, Hua Yan   +8 more
openalex   +1 more source

Mapping Escolar (Lepidocybium flavobrunneum) in Motion: Oceanographic Forces Shaping Its Habitat in the Southwestern South Atlantic, With Insights From Fishers' Perceptions

Fisheries Oceanography, EarlyView.
ABSTRACT Lepidocybium flavobrunneum [Smith, 1843], commonly known as escolar, is a large pelagic species, important for global and local fisheries, particularly in the southwestern South Atlantic Ocean (SWAO), where it constitutes a significant portion of the catch.
Lucas Rodrigues, Maria Grazia Pennino, Paul Gerhard Kinas, David Conesa, Alba Fuster‐Alonso, Andrés Domingo, Rodrigo Forselledo, Federico Mas, Bruno Mourato, Rodrigo Sant'Ana, Vinni Santos Thykjaer, Raquel Virginia Marquez Marquez, Abner Ventura Alves, Mariano Cabanillas‐Torpoco, Rafael Schroeder, Luis Gustavo Cardoso   +15 more
wiley   +1 more source

The hidden science of haptics: A pedagogical review of tactile evaluation in cosmetics

International Journal of Cosmetic Science, EarlyView.
This review explores the physiological basis of tactile perception and critically examines classical and emerging sensory methods used in cosmetics, advocating for broader methodological integration and recognition of sensory analysis in the field. Abstract Sensory analysis is a cornerstone of cosmetic development, yet remains underrepresented in peer ...
Morgane Postec, Daria Terescenco, Ecaterina Gore   +2 more
wiley   +1 more source

Topical administration of GLP-1 eyedrops improves retinal ganglion cell function by facilitating presynaptic GABA release in early experimental diabetes

Neural Regeneration Research
Diabetic retinopathy is a prominent cause of blindness in adults, with early retinal ganglion cell loss contributing to visual dysfunction or blindness.
Yu-Qi Shao, Yong-Chen Wang, Lu Wang, Hang-Ze Ruan, Yun-Feng Liu, Ti-Hui Zhang, Shi-Jun Weng, Xiong-Li Yang, Yong-Mei Zhong   +8 more
doaj   +1 more source

Allelic variance between GRM6 mutants, Grm6^nob3 and Grm6^nob4 results in differences in retinal ganglion cell visual responses

, 2008
Dennis M. Maddox, Kirstan A. Vessey, Gary L. Yarbrough, Brandon M. Invergo, Donald R. Cantrell, Samsoon Inayat, Victoria Balannik, Wanda L. Hicks, Norman L. Hawes, Shannon L. Byers, Richard S. Smith, R.E. Hurd, Douglas Howell, Ronald G. Gregg, Bo Chang, Jürgen Κ. Naggert, John B. Troy, Lawrence H. Pinto, Patsy M. Nishina, Maureen A. McCall   +19 more
openalex   +1 more source

Increased C‐reactive protein is associated with corneal nerve loss and painful neuropathic symptoms in Type 2 diabetes mellitus

Journal of Diabetes Investigation, EarlyView.
Higher circulating C‐reactive protein, a marker of systemic inflammation, is associated with reduced corneal small nerve fiber density in individuals with Type 2 diabetes mellitus. Among participants with diabetic peripheral neuropathy, CRP levels are highest in those reporting positive neuropathic symptoms such as burning, painful cold, or electric ...
Georgios Ponirakis, Ibrahim Al‐Janahi, Einas Elgassim, Ioannis N. Petropoulos, Hoda Gad, Adnan Khan, Hadeel B. Zaghloul, Hamda Ali, Mashhood A. Siddique, Sidra Abdulshakoor, Jenneth M. Concepcion, Sara H. Khalfalla, Iynas S. A. Elamin, Abeer T. H. AlZawqari, Tania Bibi, Marwa A. El Deeb, Lina H. M. Ahmed, Youssra Dakroury, Abeer M. M. El Shewehy, Iuliia Salivon, Mohammad Qasim Minhas, Yara Ismail, Mahmoud A. Zirie, Yousuf Al‐Ansari, Mariam A. O. Al‐Malaheem, Dorothy J. Quadros, Stephen L. Atkin, Rayaz A. Malik   +27 more
wiley   +1 more source

Effect of Buah Merah (Pandanus conoideus Lamk.) Extract Supplementation on the Density and Apoptosis of Photoreceptor and Retinal Ganglion Cells in a Diabetic Rat Model

Life
Diabetic retinopathy (DR) is a microvascular disorder of the retina due to diabetes mellitus (DM). Natural products are widely used to prevent and treat various diseases caused by DM.
Andi Muhammad Ichsan, Susan Waterina Salle, Itzar Chaidir Islam, Subehan Lallo, Andi Alfian Zainuddin, Budu Mannyu, Habibah Setyawati Muhiddin   +6 more
doaj   +1 more source

Neurotrophic extracellular matrix proteins promote neuronal and iPSC astrocyte progenitor cell‐ and nano‐scale process extension for neural repair applications

Journal of Anatomy, Volume 246, Issue 4, Page 585-601, April 2025.
The extracellular matrix plays a critical role in modulating cell behaviour in the central nervous system influencing neural cell morphology and growth. However, a better understanding of the impact of individual matrix proteins on both neurons and astrocytes is critical for advancing the development of matrix‐based neural repair strategies.
Cian O'Connor, Rena E. Mullally, Sarah F. McComish, Julia O'Sullivan, Ian Woods, Ingmar Schoen, Massimiliano Garre, Maeve A. Caldwell, Adrian Dervan, Fergal J. O'Brien   +9 more
wiley   +1 more source