Results 131 to 140 of about 5,405,992 (262)
Acta Neuropathologica CommunicationsLeber’s hereditary optic neuropathy (LHON) is driven by mtDNA mutations affecting Complex I presenting as progressive retinal ganglion cell dysfunction usually in the absence of extra-ophthalmic symptoms. There are no long-term neuroprotective agents for
Amin Otmani +4 more
doaj +1 more source
Eye &ENT Research, EarlyView.ABSTRACT Artificial intelligence (AI) is increasingly applied to optical coherence tomography (OCT) in ophthalmology, but evidence for automated diagnosis is stronger than evidence for longitudinal monitoring. This narrative review evaluates OCT‐based AI with emphasis on disease monitoring and progression, particularly in retinal disease and glaucoma ...
Stjepan Škudar
wiley +1 more source
Uncovering genetic factors that mark subtypes of retinal ganglion cells
, 2017 Glaucoma, the second leading cause of blindness, is characterized by the death of ganglion cells in the retina. Ganglion cells serve as the final output neurons of the retina by gathering information and relaying it to the visual centers of the brain. It
Maldonado, Gabriel
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Unwanted stimulation of retinal ganglion cell axons of passage.
, 2018 Retinal ganglion cell somas and axon initial segments represent the target regions for epiretinal stimulation (region shaded blue). Activation of passing axons in the nerve fiber layer (gray shaded region) results in long, arc-shaped visual percepts and ...
Anthony N. Burkitt (153046) +5 more
core +1 more source
Eye &ENT Research, EarlyView.ABSTRACT Artificial intelligence (AI) has advanced rapidly in glaucoma, but many models remain optimized for case‐control detection rather than the clinically harder task of distinguishing glaucoma from its mimickers. This narrative review primarily examined literature published from January 2018 to March 2026 on glaucoma AI, difficult comparator ...
Cansu Yüksel Elgin
wiley +1 more source
Inherited metabolic epilepsies–established diseases, new approaches
Epilepsia Open, EarlyView.Abstract Inherited metabolic epilepsies (IMEs) represent the inherited metabolic disorders (IMDs) in which epilepsy is a prevailing component, often determining other neurodevelopmental outcomes associated with the disorder. The different metabolic pathways affected by individual IMEs are the basis of their rarity and heterogeneity.
Itay Tokatly Latzer, Phillip L. Pearl
wiley +1 more source
Triggered Calcium Lightning Programs Cochlear Development
Exploration, EarlyView.Summary: Before the onset of hearing, the developing inner ear generates spontaneous calcium signals that are thought to guide maturation. In this study, we discovered a rapid and widespread calcium flash—dubbed “Ca2+ lightning”—originating from supporting cells beneath the sensory hair cells, which triggers coordinated calcium waves across the entire ...
Qiang Ma +13 more
wiley +1 more source
Exploration, EarlyView.This review highlights recent advances in engineering messenger RNA (mRNA)‐lipid nanoparticles (LNPs) to cross the ageing blood–brain barrier and target neurodegenerative diseases. It outlines design principles, delivery routes, and translational challenges, charting a roadmap towards clinical application of mRNA‐LNP therapeutics for neurodegenerative ...
Abdel Ali Belaidi +5 more
wiley +1 more source
Intrinsically photosensitive retinal ganglion cell [PDF]
, 2015 This graduation paper presents the histology of the eyes many segments, which include: conjunctiva, eyelids, lacrimal glands, scelra, cornea, limbus, choroid, ciliary body, iris, lens, vitreous body and the retina.
Rabatić, Leon
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