Results 121 to 130 of about 5,405,992 (262)

Mosaic activation of the zebrafish hsp70l heat shock promoter: Implications for interpreting transgenes

Developmental Dynamics, EarlyView.
Abstract Background The promoters and enhancers of heat shock genes, such as the 1.5‐kb promoter of the zebrafish hsp70l gene, are valuable tools for temporal activation of transgenes. It has been widely purported that heat shock treatments result in ubiquitous expression of hsp70l‐driven transgenes.
Jong‐Su Park, Xiangyun Wei
wiley   +1 more source

Role of SoxE transcription factors in development and disease

Developmental Dynamics, EarlyView.
Abstract Sox8, Sox9, and Sox10 arose by multiple rounds of genome duplications from a single SoxE gene in ancestral vertebrates. In this review, we will briefly discuss the molecular structure and function of SoxE transcription factors and their evolutionary origin. We will then discuss their expression, function, and developmental disorders.
Merin Lawrence, Gerhard Schlosser
wiley   +1 more source

Editorial: Molecular dynamics of cognitive-motor impairment in neurodegenerative diseases

Frontiers in Molecular Neuroscience, 2023
Dhiraj Kumar, Dhiraj Kumar, Saba Noor, Manzar Alam, Manzar Alam, Md Imtaiyaz Hassan   +5 more
doaj   +1 more source

Time-resolved single-nucleus profiling of inter- and intracellular signaling in optic nerve injury: From the hyperacute phase to the acute phase

Neural Regeneration Research
Optic nerve injury induces rapid retinal neurodegeneration; however, how distinct retinal cell type responses are coordinated from the hyperacute injury phase to the early repair phase remains incompletely understood.
Yi Ding, Wenyue Zhang, Yeli Deng, Lunhao Li, Ping Gu, Leilei Zhang, Kwok-Fai So, Caiwen Xiao   +7 more
doaj   +1 more source

Zebrafish inversin mutants develop scoliosis in the absence of laterality defects

Developmental Dynamics, EarlyView.
Abstract Background Human mutations in INVERSIN are associated with nephronophthisis, variable penetrance of situs inversus and congenital heart disease. Inversin has been shown to localize to cilia and many of the patient phenotypes are attributed to disrupted cilia function.
Christopher J. Derrick, Lorraine Eley, Deborah J. Henderson, Bill Chaudhry   +3 more
wiley   +1 more source

Zebrafish ventral gastrula fate map reveals neural crest progenitor domain

Developmental Dynamics, EarlyView.
Abstract Background Fate maps relate progenitor cell positions to later fates and locations of their progeny, revealing early embryonic organization. Previous zebrafish fate maps identified the origin of germ layers and derivative cell fates, but ventral gastrula progenitor domains were not fully resolved. In particular, the neural crest, a multipotent
Elaine E. Kushkowski, Victoria E. Prince
wiley   +1 more source

Optic Nerve Head Measurements Across Optical Coherence Tomography Platforms and Incidental Optic Nerve Head Drusen in Community Screenings

Eye &ENT Research, EarlyView.
ABSTRACT Background Automated vertical cup‐to‐disc ratio (VCDR) measurements are commonly used in optic nerve assessment, but measurements may vary across optical coherence tomography (OCT) platforms, particularly in eyes with atypical optic nerve anatomy such as optic nerve head drusen (ONHD).
Sedra T. Alabed, Aretha Zhu, Bernard C. Szirth, Albert S. Khouri   +3 more
wiley   +1 more source

Overexpressing neurogenic differentiation factor 1 in Müller cells improves retinal function after optic nerve crush injury in adult mice

Neural Regeneration Research
Optic nerve injury leads to axonal degeneration and the death of retinal ganglion cells, which ultimately causes vision loss. Notably, current treatments are limited.
Liting Zhong, Dashuang Yang, Xiu Han, Haiyang Cheng, Di Xu, Wen Li, Gong Chen, Ying Xu   +7 more
doaj   +1 more source

FUNCTIONAL RETINAL GANGLION CELL ACTIVITY FOLLOWING LIGHT-INDUCED RETINAL DAMAGE IN MICE

, 2019
The scotopic threshold response (STR) of the electroretinogram (ERG) is thought to measure inner retinal function, specifically retinal ganglion cells (RGCs).
Sy, Jezreel Justine
core  

Artificial Intelligence in Ophthalmology: From Methodological Advances to Clinical Translation and Future Directions

Eye &ENT Research, EarlyView.
ABSTRACT Artificial intelligence (AI) is reshaping ophthalmology from task‐specific image analysis toward multimodal, longitudinal, and clinically integrated decision support. This narrative review summarizes the methodological evolution of ophthalmic AI, including traditional machine learning, task‐specific deep learning, self‐supervised learning ...
Yuxin Liu, Hanruo Liu
wiley   +1 more source