Results 41 to 50 of about 119,076 (326)

Advances in retinal ganglion cell imaging [PDF]

Eye, 2015
Glaucoma is one of the leading causes of blindness worldwide and will affect 79.6 million people worldwide by 2020. It is caused by the progressive loss of retinal ganglion cells (RGCs), predominantly via apoptosis, within the retinal nerve fibre layer and the corresponding loss of axons of the optic nerve head.
S I, Balendra, E M, Normando, P A, Bloom, M F, Cordeiro   +3 more
openaire   +2 more sources

Damage and repair in retinal degenerative diseases: Molecular basis through clinical translation

Neural Regeneration Research
Retinal ganglion cells are the bridging neurons between the eye and the central nervous system, transmitting visual signals to the brain. The injury and loss of retinal ganglion cells are the primary pathological changes in several retinal degenerative ...
Ziting Zhang, Junfeng Ma, Wahid Shah, Xin Quan, Tao Ding, Yuan Gao   +5 more
doaj   +1 more source

Activated retinal glia mediated axon regeneration in experimental glaucoma

Neurobiology of Disease, 2012
Glaucoma, a leading cause of blindness, is a neurodegenerative disease characterized by progressive loss of retinal ganglion cell axons in the optic nerve and their cell bodies in the retina.
Barbara Lorber, Alessandra Guidi, James W. Fawcett, Keith R. Martin   +3 more
doaj   +1 more source

Suppressed retinal degeneration in aged wild type and APPswe/PS1ΔE9 mice by bone marrow transplantation. [PDF]

PLoS ONE, 2013
Alzheimer's disease (AD) is an age-related condition characterized by accumulation of neurotoxic amyloid β peptides (Aβ) in brain and retina. Because bone marrow transplantation (BMT) results in decreased cerebral Aβ in experimental AD, we hypothesized ...
Yue Yang, Christine Shiao, Jake Frederick Hemingway, Nikolas L Jorstad, Bryan Richard Shalloway, Rubens Chang, C Dirk Keene   +6 more
doaj   +1 more source

Stem Cells, Retinal Ganglion Cells and Glaucoma [PDF]

, 2014
Retinal ganglion cells (RGCs) represent an essential neuronal cell type for vision. These cells receive inputs from light-sensing photoreceptors via retinal interneurons and then relay these signals to the brain for further processing. RGC diseases that result in cell death, e.g.
Valentin M, Sluch, Donald J, Zack
openaire   +2 more sources

Encoding surprise by retinal ganglion cells

PLOS Computational Biology, 2022
The efficient coding hypothesis posits that early sensory neurons transmit maximal information about sensory stimuli, given internal constraints. A central prediction of this theory is that neurons should preferentially encode stimuli that are most surprising.
Danica Despotović, Corentin Joffrois, Olivier Marre, Matthew Chalk   +3 more
openaire   +3 more sources

Distribution of melanopsin positive neurons in pigmented and albino mice: evidence for melanopsin interneurons in the mouse retina. [PDF]

, 2014
Here we have studied the population of intrinsically photosensitive retinal ganglion cells (ipRGCs) in adult pigmented and albino mice. Our data show that although pigmented (C57Bl/6) and albino (Swiss) mice have a similar total number of ipRGCs, their ...
Agudo-Barriuso, M, Galindo-Romero, C, García-Ayuso, D, Jiménez-López, M, Ortín-Martínez, A, Valiente-Soriano, FJ, Vidal-Sanz, M, Villegas-Pérez, MP, Vugler, AA   +8 more
core  

Attenuation of the Ganglion Cell Layer in a Premature Infant Revealed with Handheld Spectral Domain Optical Coherence Tomography [PDF]

, 2016
Purpose: To report on subclinical retinal abnormalities shown through handheld spectral domain optical coherence tomography on a premature infant. Methods: Case report.
Carroll, Joseph, Costakos, Deborah M., Goldberg, Mara R., Zakka, Fouad R.   +3 more
core   +2 more sources

The role and implications of mammalian cellular circadian entrainment

FEBS Letters, EarlyView.
At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley   +1 more source

Otx2 stimulates adult retinal ganglion cell regeneration [PDF]

Neural Regeneration Research, 2020
AbstractRetinal ganglion cell axons provide the only link between the light sensitive and photon transducing neural retina and visual centers of the brain. Retinal ganglion cell axon degeneration occurs in a number of blinding diseases and the ability to stimulate axon regeneration from surviving ganglion cells could provide the anatomic substrate for ...
Ibad, Raoul Torero, Quenech’du, Nicole, Prochiantz, Alain, Moya, Kenneth   +3 more
openaire   +3 more sources