Results 11 to 20 of about 68,022 (253)

Tissue engineering the retinal ganglion cell nerve fiber layer [PDF]

Biomaterials, 2013
Retinal degenerative diseases, such as glaucoma and macular degeneration, affect millions of people worldwide and ultimately lead to retinal cell death and blindness. Cell transplantation therapies for photoreceptors demonstrate integration and restoration of function, but transplantation into the ganglion cell layer is more complex, requiring guidance
Karl E, Kador, Ramon B, Montero, Praseeda, Venugopalan, Jonathan, Hertz, Allison N, Zindell, Daniel A, Valenzuela, Mohammed S, Uddin, Erin B, Lavik, Kenneth J, Muller, Fotios M, Andreopoulos, Jeffrey L, Goldberg   +10 more
openaire   +4 more sources

Relationship between Ganglion Cell Layer Thickness and Estimated Retinal Ganglion Cell Counts in the Glaucomatous Macula [PDF]

Ophthalmology, 2014
To investigate the relationship between macular ganglion cell-inner plexiform layer (mGCIPL) thickness and estimated macular retinal ganglion cell (RGC) counts in glaucoma.Observational cohort study.Cross-sectional study of 77 healthy, 154 glaucoma suspect, and 159 glaucomatous eyes from the Diagnostic Innovations in Glaucoma Study.All eyes underwent ...
Zhang, Chunwei, Tatham, Andrew J, Weinreb, Robert N, Zangwill, Linda M, Yang, Zhiyong, Zhang, James Z, Medeiros, Felipe A   +6 more
openaire   +6 more sources

Decreased Retinal Ganglion Cell Layer Thickness in Patients with Type 1 Diabetes [PDF]

Investigative Opthalmology & Visual Science, 2010
PURPOSE. To determine which retinal layers are most affected by diabetes and contribute to thinning of the inner retina and to investigate the relationship between retinal layer thickness (LT) and diabetes duration, diabetic retinopathy (DR) status, age, glycosylated hemoglobin (HbA1c), and the sex of the individual, in patients with type 1 diabetes ...
Dijk, Hille W. van, Verbraak, Frank D., Kok, Pauline H. B., Garvin, Mona K., Sonka, Milan, Lee, Kyungmoo, DeVries, J. Hans, Michels, Robert P. J., Velthoven, Mirjam E. J. van, Schlingemann, Reinier O., Abramoff, M.D.   +10 more
openaire   +5 more sources

Selective deletion of zinc transporter 3 in amacrine cells promotes retinal ganglion cell survival and optic nerve regeneration after injury

Neural Regeneration Research, 2023
[INLINE:1] Vision depends on accurate signal conduction from the retina to the brain through the optic nerve, an important part of the central nervous system that consists of bundles of axons originating from retinal ganglion cells.
Zhe Liu, Jingfei Xue, Canying Liu, Jiahui Tang, Siting Wu, Jicheng Lin, Jiaxu Han, Qi Zhang, Caiqing Wu, Haishun Huang, Ling Zhao, Yehong Zhuo, Yiqing Li   +12 more
doaj   +1 more source

Cell birth and death in the mouse retinal ganglion cell layer [PDF]

The Journal of Comparative Neurology, 2005
Here we describe quantitatively the birth and death of the two separate populations of neurons, ganglion cells and displaced amacrine cells, in the mouse retinal ganglion cell layer (GCL). The two cell types, which are roughly equally numerous, were distinguished pre- and postnatally by labeling the ganglion cells retrogradely with fluorescent dye ...
Farah, Mohamed H., Easter, Stephen S.
openaire   +3 more sources

Neuroimaging and cognitive correlates of retinal Optical Coherence Tomography (OCT) measures at late middle age in a twin sample

Scientific Reports, 2022
Sharing in embryology and function between the eye and brain has led to interest in whether assessments of the eye reflect brain changes seen in neurodegeneration.
Chris Moran, Zheng Yang Xu, Hemal Mehta, Mark Gillies, Chris Karayiannis, Richard Beare, Christine Chen, Velandai Srikanth   +7 more
doaj   +1 more source

Alterations of retinal thickness measured by optical coherence tomography correlate with neurophysiological measures in diabetic polyneuropathy

Journal of Diabetes Investigation, 2021
Aims/Introduction Diabetic polyneuropathy (DPN) and diabetic retinopathy (DR) are traditionally regarded as microvascular complications. However, these complications may share similar neurodegenerative pathologies.
Yuichiro Yamada, Tatsuhito Himeno, Kotaro Tsuboi, Yuka Shibata, Miyuka Kawai, Yuriko Asada‐Yamada, Yusuke Hayashi, Emi Asano‐Hayami, Tomohide Hayami, Yuichiro Ishida, Yohei Ejima, Mikio Motegi, Saeko Asano, Makoto Kato, Eriko Nagao, Hiromi Nakai‐Shimoda, Takahiro Ishikawa, Yoshiaki Morishita, Masaki Kondo, Shin Tsunekawa, Yoshiro Kato, Takayuki Nakayama, Motohiro Kamei, Jiro Nakamura, Hideki Kamiya   +24 more
doaj   +1 more source

Differences in macular pigment optical density across four ethnicities: a comparative study

Therapeutic Advances in Ophthalmology, 2020
Objective: The aim of this study is to compare macular pigment optical density levels across four different ethnicities and study its influence on ganglion cell layer and retinal nerve fibre layer thickness across these ethnicities.
Pinakin Gunvant Davey, Christopher Lievens, Stephanie Amonoo-Monney   +2 more
doaj   +1 more source

Retinal ganglion cell loss is accompanied by antibody depositions and increased levels of microglia after immunization with retinal antigens. [PDF]

PLoS ONE, 2012
BackgroundAntibodies against retinal and optic nerve antigens are detectable in glaucoma patients. Recent studies using a model of experimental autoimmune glaucoma demonstrated that immunization with certain ocular antigens causes an immun-mediated ...
Stephanie C Joachim, Oliver W Gramlich, Panagiotis Laspas, Heiko Schmid, Sabine Beck, Harald D von Pein, H Burkhard Dick, Norbert Pfeiffer, Franz H Grus   +8 more
doaj   +1 more source

Dendritic and axonal targeting patterns of a genetically-specified class of retinal ganglion cells that participate in image-forming circuits. [PDF]

, 2014
BackgroundThere are numerous functional types of retinal ganglion cells (RGCs), each participating in circuits that encode a specific aspect of the visual scene.
Feldheim, David A, Feller, Marla B, Gonzalez, Cristina, Huberman, Andrew D, Sweeney, Neal T, Triplett, Jason W, Wei, Wei   +6 more
core   +2 more sources