Results 51 to 60 of about 286,988 (401)

Bone Marrow‐Derived Mesenchymal Stem Cells‐Derived Exosomes Promote Survival of Retinal Ganglion Cells Through miRNA‐Dependent Mechanisms

Stem Cells Translational Medicine, 2017
The loss of retinal ganglion cells (RGC) and their axons is one of the leading causes of blindness and includes traumatic (optic neuropathy) and degenerative (glaucoma) eye diseases. Although no clinical therapies are in use, mesenchymal stem cells (MSC)
B. Mead, S. Tomarev
semanticscholar   +1 more source

Testing for Multidimensional Color-Emotion Semantic Space [PDF]

, 2015
A subset of retinal ganglion cells expresses melanopsin, a photo-pigment with absorption spectrum peaking at 480 nm (i.e., blue light). These cells can directly respond to light even without classic photoreceptor rods and cones, and are named ...
Alfaro, Catarina, Amano, Kinjiro, Bailão, Ana, Freitas, Maria Helena de, João, Catarina Alexandra Rodrigues, Linhares, João M. M., Melo, Maria J., Montagner, Cristina, Nascimento, Sérgio M. C., Vilarigues, Márcia   +9 more
core   +6 more sources

Assessing retinal ganglion cell damage [PDF]

Eye, 2017
Retinal ganglion cell (RGC) loss is the hallmark of optic neuropathies, including glaucoma, where damage to RGC axons occurs at the level of the optic nerve head. In experimental glaucoma, damage is assessed at the axon level (in the retinal nerve fibre layer and optic nerve head) or at the soma level (in the retina).
Corey A. Smith, Balwantray C. Chauhan, Jayme R Vianna   +2 more
openaire   +3 more sources

Digestion of the glycosaminoglycan extracellular matrix by chondroitinase ABC supports retinal ganglion cell dendritic preservation in a rodent model of experimental glaucoma

Molecular Brain, 2018
Retinal ganglion cell dendritic atrophy is an early feature of glaucoma, and the recovery of retinal ganglion cell dendrites is a viable option for vision improvement in glaucoma.
James R. Tribble, Pete A. Williams, Bruce Caterson, Frank Sengpiel, James E. Morgan   +4 more
doaj   +1 more source

Degeneration of human photosensitive retinal ganglion cells may explain sleep and circadian rhythms disorders in Parkinson’s disease

Acta Neuropathologica Communications, 2018
Parkinson’s disease (PD) patients often suffer from non-motor symptoms like sleep dysregulation, mood disturbances or circadian rhythms dysfunction. The melanopsin-containing retinal ganglion cells are involved in the control and regulation of these ...
Isabel Ortuño-Lizarán, Gema Esquiva, T. Beach, G. Serrano, C. Adler, P. Lax, N. Cuenca   +6 more
semanticscholar   +1 more source

Nel positively regulates the genesis of retinal ganglion cells by promoting their differentiation and survival during development [PDF]

, 2014
Peer reviewedPublisher ...
Adams JC, Agathocleous M, Aihara K, Amy S. Findlay, Austin CP, Cayouette M, Cepko CL, Chizu Nakamoto, de Iongh R, Ehrlich D, Elaine Durward, Ewa D. Zakrzewska, Fekete DM, Flanagan JG, Frade JM, Galvez JM, Hansen MJ, Harada H, Harpavat S, Hashimoto T, Holt CE, Hu WY, Isenmann S, Jablonski MM, Jablonski MM, Jiang Y, Jiang Y, Katahira T, Koga A, Kuroda S, Layer PG, Marianne Bronner, Martinez-Morales JR, Masai I, Masaru Nakamoto, Matsuhashi S, Matsuhashi S, Matsuoka H, Matsuyama S, Matsuyama S, McCabe KL, McCabe KL, McLaughlin T, Moore SW, Munemasa Y, Nakamura R, Nelson BR, Nelson BR, Oyasu M, Patel A, Prada C, Price J, Rachel RA, Raymond SM, Sato Y, Snow RL, Soh-Leh Kuan, Stiemke MM, Strauss O, Takuma Endo, Wang JT, Watanabe TK, Wetts R, Xiang M, Yee JK, Zhang XM, Zhang XM, Zhufeng Ouyang   +67 more
core   +1 more source

c-Jun N-terminal kinase 3 expression in the retina of ocular hypertension mice: a possible target to reduce ganglion cell apoptosis

Neural Regeneration Research, 2015
Glaucoma, a type of optic neuropathy, is characterized by the loss of retinal ganglion cells. It remains controversial whether c-Jun N-terminal kinase (JNK) participates in the apoptosis of retinal ganglion cells in glaucoma. This study sought to explore
Yue He, Jie Chen, Shu-guang Zhang, Yuan-sheng Yuan, Yan Li, Hong-bin Lv, Jin-hua Gan   +6 more
doaj   +1 more source

Spatial distribution of excitatory synapses on the dendrites of ganglion cells in the mouse retina. [PDF]

PLoS ONE, 2014
Excitatory glutamatergic inputs from bipolar cells affect the physiological properties of ganglion cells in the mammalian retina. The spatial distribution of these excitatory synapses on the dendrites of retinal ganglion cells thus may shape their ...
Yin-Peng Chen, Chuan-Chin Chiao
doaj   +1 more source

Three-Dimensional Retinal Organoids Facilitate the Investigation of Retinal Ganglion Cell Development, Organization and Neurite Outgrowth from Human Pluripotent Stem Cells

Scientific Reports, 2018
Retinal organoids are three-dimensional structures derived from human pluripotent stem cells (hPSCs) which recapitulate the spatial and temporal differentiation of the retina, serving as effective in vitro models of retinal development.
Clarisse M. Fligor, Kirstin B. Langer, Akshayalakshmi Sridhar, Yuan Ren, P. K. Shields, Michael C. Edler, Sarah K. Ohlemacher, Valentin M. Sluch, D. Zack, Chi Zhang, D. Suter, Jason S. Meyer   +11 more
semanticscholar   +1 more source

Connecting the Retina to the Brain [PDF]

, 2014
The authors disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: Work in the laboratory of LE is funded by the BBSRC [BB/J00815X/1] and the R.S. Macdonald Charitable Trust. Research in the
Erskine, Lynda, Herrera, Eloisa
core   +3 more sources