Results 31 to 40 of about 4,628,424 (310)

Activation of BMP-Smad1/5/8 signaling promotes survival of retinal ganglion cells after damage in vivo. [PDF]

PLoS ONE, 2012
While the essential role of bone morphogenetic protein (BMP) signaling in nervous system development is well established, its function in the adult CNS is poorly understood.
Yumi Ueki, Thomas A Reh
doaj   +1 more source

Targeting retinal ganglion cell recovery [PDF]

Eye, 2017
Accumulating evidence from experimental and clinical studies suggest that retinal ganglion cells at least in the earlier stages of glaucoma have the capacity to recover function following periods of functional loss. The capacity for recovery may be negatively impacted by advancing age but can be boosted by interventions such as diet restriction and ...
J G, Crowston, E T, Fahy, L, Fry, I A, Trounce, P, van Wijngaarden, S, Petrou, V, Chrysostomou   +6 more
openaire   +2 more sources

The diverse roles of inhibition in identified neural circuits [PDF]

, 2010
Inhibitory interneurons represent a diverse population of cell types in the central nervous system, whose general role is to suppress activity of target neurons.
Viney, Tim James
core   +1 more source

Gender difference in the neuroprotective effect of rat bone marrow mesenchymal cells against hypoxia-induced apoptosis of retinal ganglion cells

Neural Regeneration Research, 2016
Bone marrow mesenchymal stem cells can reduce retinal ganglion cell death and effectively prevent vision loss. Previously, we found that during differentiation, female rhesus monkey bone marrow mesenchymal stem cells acquire a higher neurogenic potential
Jing Yuan, Jian-xiong Yu
doaj   +1 more source

Hyperactivity of ON-type retinal ganglion cells in streptozotocin-induced diabetic mice. [PDF]

PLoS ONE, 2013
Impairment of visual function has been detected in the early stage of diabetes but the underlying neural mechanisms involved are largely unknown.
Jun Yu, Lu Wang, Shi-Jun Weng, Xiong-Li Yang, Dao-Qi Zhang, Yong-Mei Zhong   +5 more
doaj   +1 more source

Assessing retinal ganglion cell damage [PDF]

Eye, 2017
Retinal ganglion cell (RGC) loss is the hallmark of optic neuropathies, including glaucoma, where damage to RGC axons occurs at the level of the optic nerve head. In experimental glaucoma, damage is assessed at the axon level (in the retinal nerve fibre layer and optic nerve head) or at the soma level (in the retina).
C A, Smith, J R, Vianna, B C, Chauhan
openaire   +2 more sources

HIF-1 expression in retinal ganglion cells and optic nerve axons in glaucoma HIF-1 expression in retinal ganglion cells and optic nerve axons in glaucoma

Folia Histochemica et Cytobiologica, 2012
Glaucoma is a result of increased intraocular pressure leading to damage to retinal ganglion cells and<br />optic nerve axons. The aim of this study was to evaluate HIF-1 expression in optic nerve axons and retinal<br />ganglion cells in 42 ...
Joanna Reszeć, Renata Zalewska, Piotr Bernaczyk, Lech Chyczewski   +3 more
doaj   +1 more source

Cell-Based Neuroprotection of Retinal Ganglion Cells in Animal Models of Optic Neuropathies

Biology, 2021
Retinal ganglion cells (RGCs) comprise a heterogenous group of projection neurons that transmit visual information from the retina to the brain. Progressive degeneration of these cells, as it occurs in inflammatory, ischemic, traumatic or glaucomatous ...
Yue Hu, Lynn Michelle Grodzki, Susanne Bartsch, Udo Bartsch   +3 more
doaj   +1 more source

Susceptibility to neurodegeneration in a glaucoma is modified by Bax gene dosage. [PDF]

PLoS Genetics, 2005
In glaucoma, harmful intraocular pressure often contributes to retinal ganglion cell death. It is not clear, however, if intraocular pressure directly insults the retinal ganglion cell axon, the soma, or both.
Richard T Libby, Yan Li, Olga V Savinova, Joseph Barter, Richard S Smith, Robert W Nickells, Simon W M John   +6 more
doaj   +2 more sources

Novel rodent models for macular research [PDF]

, 2010
BACKGROUND: Many disabling human retinal disorders involve the central retina, particularly the macula. However, the commonly used rodent models in research, mouse and rat, do not possess a macula.
Gesine Huber, Muehlfriedel, Regine, Huber, G., Feng, Yuxi, Seeliger, M., Tanimoto, Naoyuki, Tanimoto Naoyuki, Severin Heynen, Hans-Peter Hammes, Christian Grimm, Feng, Y., Imsand Coni, Imsand, Coni, Muehlfriedel Regine, Susanne C. Beck, Huber, Gesine, Heynen, S., Grimm Christian, Regine Muehlfriedel, Huber Gesine, vom Hagen Franziska, Coni Imsand, Imsand, C., Seeliger Mathias W., Mühlfriedel, R., Peichl, Leo, Mathias W Seeliger, vom Hagen, F., Mühlfriedel, Regine, Tanimoto, N., Heynen Severin, Hammes, Hans-Peter, Seeliger, Mathias W, Beck Susanne C., Seeliger, Mathias W., Peichl Leo, Yuxi Feng, Peichl, L., Beck, Susanne C; https://orcid.org/, Grimm, C., Feng Yuxi, Mathias W. Seeliger, Leo Peichl, Franziska vom Hagen, Grimm, Christian, Grimm, Christian; https://orcid.org/, vom Hagen, Franziska, Beck, S., Beck, Susanne Christiane, Hammes Hans-Peter, Susanne C Beck, Naoyuki Tanimoto, Hammes, H., Heynen, Severin   +53 more
core   +2 more sources