Results 31 to 40 of about 109,464 (277)

HIF-1 expression in retinal ganglion cells and optic nerve axons in glaucoma HIF-1 expression in retinal ganglion cells and optic nerve axons in glaucoma

Folia Histochemica et Cytobiologica, 2012
Glaucoma is a result of increased intraocular pressure leading to damage to retinal ganglion cells and<br />optic nerve axons. The aim of this study was to evaluate HIF-1 expression in optic nerve axons and retinal<br />ganglion cells in 42 ...
Joanna Reszeć, Renata Zalewska, Piotr Bernaczyk, Lech Chyczewski   +3 more
doaj   +1 more source

RdgB2 is required for dim-light input into intrinsically photosensitive retinal ganglion cells. [PDF]

, 2015
A subset of retinal ganglion cells is intrinsically photosensitive (ipRGCs) and contributes directly to the pupillary light reflex and circadian photoentrainment under bright-light conditions.
Berson, David M, Elsaesser, Rebecca, Güler, Ali D, Hattar, Samer, Montell, Craig, Rupp, Alan, Sheng, Wenlong, Walker, Marquis T, Weng, Shijun   +8 more
core   +2 more sources

Pluripotent Stem Cell-Based Approaches to Explore and Treat Optic Neuropathies

Frontiers in Neuroscience, 2018
Sight is a major sense for human and visual impairment profoundly affects quality of life, especially retinal degenerative diseases which are the leading cause of irreversible blindness worldwide.
Oriane Rabesandratana, Olivier Goureau, Gaël Orieux   +2 more
doaj   +1 more source

Modulation of the expression of the transcription factor Max in rat retinal ganglion cells by a recombinant adeno-associated viral vector

Brazilian Journal of Medical and Biological Research, 2005
Exclusion of the transcription factor Max from the nucleus of retinal ganglion cells is an early, caspase-independent event of programmed cell death following damage to the optic axons.
H. Petrs-Silva, V. Chiodo, L.B. Chiarini, W.W. Hauswirth, R. Linden   +4 more
doaj   +1 more source

Neuroprotection of retinal ganglion cells by the sigma-1 receptor agonist pridopidine in models of experimental glaucoma

Scientific Reports, 2021
Optic neuropathies such as glaucoma are characterized by retinal ganglion cell (RGC) degeneration and death. The sigma-1 receptor (S1R) is an attractive target for treating optic neuropathies as it is highly expressed in RGCs, and its absence causes ...
Michal Geva, Noga Gershoni-Emek, Luana Naia, Philip Ly, Sandra Mota, Ana Cristina Rego, Michael R. Hayden, Leonard A. Levin   +7 more
doaj   +1 more source

Transformation of stimulus correlations by the retina [PDF]

, 2013
Redundancies and correlations in the responses of sensory neurons seem to waste neural resources but can carry cues about structured stimuli and may help the brain to correct for response errors.
Balasubramanian, V., Homann, J., Nelson, P. C., Palmer, S. E., Prentice, J. S., Simmons, K. D., Tkacik, G., Yee, H. K.   +7 more
core   +7 more sources

Adamts10 controls transforming growth factor β family signaling that contributes to retinal ganglion cell development

Frontiers in Molecular Biosciences, 2022
Although mutations in ADAMTS10 have long been known to cause autosomal recessive Weill-Marchesani Syndrome which is characterized by short stature and ocular abnormalities, more recent work has shown that certain mutations in ADAMTS10 cause glaucoma in ...
Lauren K. Wareham, Amy E. Whitener, Hang-Jing Wu, Shu-Yu Wu, Hassane S. Mchaourab, Douglas P. Mortlock, Rachel W. Kuchtey, Rachel W. Kuchtey, John Kuchtey   +8 more
doaj   +1 more source

Therapeutic potential of co-enzyme Q10 in retinal diseases [PDF]

, 2017
Coenzyme Q10 (CoQ10) plays a critical role in mitochondrial oxidative phosphorylation by serving as an electron carrier in the respiratory electron transport chain.
Marcheggiani, Fabio, Reilly, James, Shu, Xinhua, Tiano, Luca, Tohari, Ali Mohammad, Zhang, Xun, Zhou, Xinzhi   +6 more
core   +1 more source

Identification of a natively resilient but poorly regenerating retinal ganglion cell type in the G protein-coupled receptor 88-Cre transgenic mouse

Neural Regeneration Research
Retinal ganglion cells are susceptible to neurodegenerative conditions and their death drives common forms of irreversible vision loss. In mice, there are 46 transcriptionally unique retinal ganglion cell types that demonstrate different susceptibilities
Allison L. Hall, Christopher Zhao, Sean McCracken, Minglei Zhao, Zelun Wang, Andrea Santeford, Rajendra S. Apte, Philip R. Williams   +7 more
doaj   +1 more source

Decellularised extracellular matrix-derived peptides from neural retina and retinal pigment epithelium enhance the expression of synaptic markers and light responsiveness of human pluripotent stem cell derived retinal organoids [PDF]

, 2019
Tissue specific extracellular matrices (ECM) provide structural support and enable access to molecular signals and metabolites, which are essential for directing stem cell renewal and differentiation.
Al-Aama, Jumana, Asfour, Hani Z., Ding, Yuchun, Doherty, Mary, Dorgau, Birthe, Felemban, Majed, Hallam, Dean, Hilgen, Gerrit, Hunt, Nicola Claire, Kiening, Martin, Krasnogor, Natalio, Lako, Majlinda, Sernagor, Evelyne, White, Kathryn, Whitfield, Phil, Zerti, Darin   +15 more
core   +2 more sources