Results 31 to 40 of about 60,940 (264)

Identification of a natively resilient but poorly regenerating retinal ganglion cell type in the G protein-coupled receptor 88-Cre transgenic mouse

Neural Regeneration Research
Retinal ganglion cells are susceptible to neurodegenerative conditions and their death drives common forms of irreversible vision loss. In mice, there are 46 transcriptionally unique retinal ganglion cell types that demonstrate different susceptibilities
Allison L. Hall, Christopher Zhao, Sean McCracken, Minglei Zhao, Zelun Wang, Andrea Santeford, Rajendra S. Apte, Philip R. Williams   +7 more
doaj   +1 more source

R-28 cell-derived extracellular vesicles protect retinal ganglion cells in glaucoma

Neural Regeneration Research
Glaucoma is characterized by chronic progressive optic nerve damage and retinal ganglion cell death. Although extensive research has been conducted on neuroprotection for retinal ganglion cells, there is still no treatment for clinical use.
Esmahan Durmaz, Maryam Esmaeili, Philip Lewis, Gloria Cimaglia, Aled Clayton, Ben Mead   +5 more
doaj   +1 more source

Spatially and Temporally Regulated NRF2 Gene Therapy Using Mcp-1 Promoter in Retinal Ganglion Cell Injury

Molecular Therapy: Methods & Clinical Development, 2017
Retinal ganglion cell degeneration triggered by axonal injury is believed to underlie many ocular diseases, including glaucoma and optic neuritis. In these diseases, retinal ganglion cells are affected unevenly, both spatially and temporally, such that ...
Kosuke Fujita, Koji M. Nishiguchi, Yukihiro Shiga, Toru Nakazawa   +3 more
doaj   +1 more source

Digestion of the glycosaminoglycan extracellular matrix by chondroitinase ABC supports retinal ganglion cell dendritic preservation in a rodent model of experimental glaucoma

Molecular Brain, 2018
Retinal ganglion cell dendritic atrophy is an early feature of glaucoma, and the recovery of retinal ganglion cell dendrites is a viable option for vision improvement in glaucoma.
James R. Tribble, Pete A. Williams, Bruce Caterson, Frank Sengpiel, James E. Morgan   +4 more
doaj   +1 more source

c-Jun N-terminal kinase 3 expression in the retina of ocular hypertension mice: a possible target to reduce ganglion cell apoptosis

Neural Regeneration Research, 2015
Glaucoma, a type of optic neuropathy, is characterized by the loss of retinal ganglion cells. It remains controversial whether c-Jun N-terminal kinase (JNK) participates in the apoptosis of retinal ganglion cells in glaucoma. This study sought to explore
Yue He, Jie Chen, Shu-guang Zhang, Yuan-sheng Yuan, Yan Li, Hong-bin Lv, Jin-hua Gan   +6 more
doaj   +1 more source

Comparison of AAV-Mediated Optogenetic Vision Restoration between Retinal Ganglion Cell Expression and ON Bipolar Cell Targeting

Molecular Therapy: Methods & Clinical Development, 2020
The loss of photoreceptors in individuals with retinal degenerative diseases leads to partial or complete blindness. Optogenetic therapy is a promising approach for restoring vision to the blind.
Qi Lu, Tushar H. Ganjawala, Andrea Krstevski, Gary W. Abrams, Zhuo-Hua Pan   +4 more
doaj   +1 more source

Retinal Processing: Insights from Mathematical Modelling

Journal of Imaging, 2022
The retina is the entrance of the visual system. Although based on common biophysical principles, the dynamics of retinal neurons are quite different from their cortical counterparts, raising interesting problems for modellers.
Bruno Cessac
doaj   +1 more source

PANoptosis of Retinal Ganglion Cells

Journal of Integrative Neuroscience
PANoptosis represents a novel form of programmed cell death regulated and controlled by the PANoptosome. It encompasses the essential features of apoptosis, necroptosis, and pyroptosis and combines elements from each process. PANoptosis contributes to the development of various diseases, including bacterial and viral infections, tumors, inflammatory ...
Xuejing Lu, Qiaoqiao Kong, Wenjia Qu, Yixiang Jiang   +3 more
openaire   +2 more sources

Damage and repair in retinal degenerative diseases: Molecular basis through clinical translation

Neural Regeneration Research
Retinal ganglion cells are the bridging neurons between the eye and the central nervous system, transmitting visual signals to the brain. The injury and loss of retinal ganglion cells are the primary pathological changes in several retinal degenerative ...
Ziting Zhang, Junfeng Ma, Wahid Shah, Xin Quan, Tao Ding, Yuan Gao   +5 more
doaj   +1 more source

Spatial distribution of excitatory synapses on the dendrites of ganglion cells in the mouse retina. [PDF]

PLoS ONE, 2014
Excitatory glutamatergic inputs from bipolar cells affect the physiological properties of ganglion cells in the mammalian retina. The spatial distribution of these excitatory synapses on the dendrites of retinal ganglion cells thus may shape their ...
Yin-Peng Chen, Chuan-Chin Chiao
doaj   +1 more source