Results 31 to 40 of about 15,573 (263)

Modulation of the expression of the transcription factor Max in rat retinal ganglion cells by a recombinant adeno-associated viral vector

Brazilian Journal of Medical and Biological Research, 2005
Exclusion of the transcription factor Max from the nucleus of retinal ganglion cells is an early, caspase-independent event of programmed cell death following damage to the optic axons.
H. Petrs-Silva, V. Chiodo, L.B. Chiarini, W.W. Hauswirth, R. Linden   +4 more
doaj   +1 more source

Neuroprotection of retinal ganglion cells by the sigma-1 receptor agonist pridopidine in models of experimental glaucoma

Scientific Reports, 2021
Optic neuropathies such as glaucoma are characterized by retinal ganglion cell (RGC) degeneration and death. The sigma-1 receptor (S1R) is an attractive target for treating optic neuropathies as it is highly expressed in RGCs, and its absence causes ...
Michal Geva, Noga Gershoni-Emek, Luana Naia, Philip Ly, Sandra Mota, Ana Cristina Rego, Michael R. Hayden, Leonard A. Levin   +7 more
doaj   +1 more source

Luminance and contrast adaptation of the inner retina [PDF]

, 2015
Adaptation is a common feature of sensory systems, matching neural activity to the range of inputs from the environment. In the visual system this is of great importance because visual stimulus can change across 9 orders of magnitude.
Santos Caracol Teixeira, Miguel Henriques dos
core   +1 more source

Identification of a natively resilient but poorly regenerating retinal ganglion cell type in the G protein-coupled receptor 88-Cre transgenic mouse

Neural Regeneration Research
Retinal ganglion cells are susceptible to neurodegenerative conditions and their death drives common forms of irreversible vision loss. In mice, there are 46 transcriptionally unique retinal ganglion cell types that demonstrate different susceptibilities
Allison L. Hall, Christopher Zhao, Sean McCracken, Minglei Zhao, Zelun Wang, Andrea Santeford, Rajendra S. Apte, Philip R. Williams   +7 more
doaj   +1 more source

Long-term gene therapy causes transgene-specific changes in the morphology of regenerating retinal ganglion cells

, 2012
Recombinant adeno-associated viral (rAAV) vectors can be used to introduce neurotrophic genes into injured CNS neurons, promoting survival and axonal regeneration.
Rodger Jennifer, Hellström Mats, Alan R Harvey, Jennifer Rodger, Mats Hellström, Hellström, M., Robertson, D., Harvey, A.R., Donald Robertson, Drummond Eleanor S., Harvey Alan R., Eleanor S Drummond, Rodger, J., Drummond, E.S., Robertson Donald   +14 more
core   +1 more source

Adamts10 controls transforming growth factor β family signaling that contributes to retinal ganglion cell development

Frontiers in Molecular Biosciences, 2022
Although mutations in ADAMTS10 have long been known to cause autosomal recessive Weill-Marchesani Syndrome which is characterized by short stature and ocular abnormalities, more recent work has shown that certain mutations in ADAMTS10 cause glaucoma in ...
Lauren K. Wareham, Amy E. Whitener, Hang-Jing Wu, Shu-Yu Wu, Hassane S. Mchaourab, Douglas P. Mortlock, Rachel W. Kuchtey, Rachel W. Kuchtey, John Kuchtey   +8 more
doaj   +1 more source

Non-viral delivery and optimized optogenetic stimulation of retinal ganglion cells led to behavioral restoration of vision

, 2012
Stimulation of retinal neurons using optogenetics via use of chanelrhodopsin-2 (ChR2) has opened up a new direction for restoration of vision for treatment of retinitis pigmentosa (RP).
Shivaranjani Shivalingaiah, Samarendra Mohanty, Mathew Ficinski, Ling Gu, Edward Wong   +4 more
core   +1 more source

R-28 cell-derived extracellular vesicles protect retinal ganglion cells in glaucoma

Neural Regeneration Research
Glaucoma is characterized by chronic progressive optic nerve damage and retinal ganglion cell death. Although extensive research has been conducted on neuroprotection for retinal ganglion cells, there is still no treatment for clinical use.
Esmahan Durmaz, Maryam Esmaeili, Philip Lewis, Gloria Cimaglia, Aled Clayton, Ben Mead   +5 more
doaj   +1 more source

Digestion of the glycosaminoglycan extracellular matrix by chondroitinase ABC supports retinal ganglion cell dendritic preservation in a rodent model of experimental glaucoma

Molecular Brain, 2018
Retinal ganglion cell dendritic atrophy is an early feature of glaucoma, and the recovery of retinal ganglion cell dendrites is a viable option for vision improvement in glaucoma.
James R. Tribble, Pete A. Williams, Bruce Caterson, Frank Sengpiel, James E. Morgan   +4 more
doaj   +1 more source

Spatially and Temporally Regulated NRF2 Gene Therapy Using Mcp-1 Promoter in Retinal Ganglion Cell Injury

Molecular Therapy: Methods & Clinical Development, 2017
Retinal ganglion cell degeneration triggered by axonal injury is believed to underlie many ocular diseases, including glaucoma and optic neuritis. In these diseases, retinal ganglion cells are affected unevenly, both spatially and temporally, such that ...
Kosuke Fujita, Koji M. Nishiguchi, Yukihiro Shiga, Toru Nakazawa   +3 more
doaj   +1 more source