Organization of the dorsal lateral geniculate nucleus in the mouse [PDF]
, 2017 The dorsal lateral geniculate nucleus (dLGN) of the thalamus is the principal conduit for visual information from retina to visual cortex. Viewed initially as a simple relay, recent studies in the mouse reveal far greater complexity in the way input from
Guido, William, Kerschensteiner, Daniel
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Activation of BMP-Smad1/5/8 signaling promotes survival of retinal ganglion cells after damage in vivo. [PDF]
PLoS ONE, 2012 While the essential role of bone morphogenetic protein (BMP) signaling in nervous system development is well established, its function in the adult CNS is poorly understood.
Yumi Ueki, Thomas A Reh
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Cell transplantation to replace retinal ganglion cells faces challenges – the Switchboard Dilemma
Neural Regeneration Research, 2021 The mammalian retina displays incomplete intrinsic regenerative capacities; therefore, retina degeneration is a major cause of irreversible blindness such as glaucoma, age-related macular degeneration and diabetic retinopathy.
Yuan Liu, Richard K Lee
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Elevated expression of human bHLH factor ATOH7 accelerates cell cycle progression of progenitors and enhances production of avian retinal ganglion cells. [PDF]
, 2018 The production of vertebrate retinal projection neurons, retinal ganglion cells (RGCs), is regulated by cell-intrinsic determinants and cell-to-cell signaling events.
Hashimoto, Takao +3 more
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Hyperactivity of ON-type retinal ganglion cells in streptozotocin-induced diabetic mice. [PDF]
PLoS ONE, 2013 Impairment of visual function has been detected in the early stage of diabetes but the underlying neural mechanisms involved are largely unknown.
Jun Yu +5 more
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Susceptibility to neurodegeneration in a glaucoma is modified by Bax gene dosage. [PDF]
PLoS Genetics, 2005 In glaucoma, harmful intraocular pressure often contributes to retinal ganglion cell death. It is not clear, however, if intraocular pressure directly insults the retinal ganglion cell axon, the soma, or both.
Richard T Libby +6 more
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Neural Regeneration Research, 2016 Bone marrow mesenchymal stem cells can reduce retinal ganglion cell death and effectively prevent vision loss. Previously, we found that during differentiation, female rhesus monkey bone marrow mesenchymal stem cells acquire a higher neurogenic potential
Jing Yuan, Jian-xiong Yu
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Cell-Based Neuroprotection of Retinal Ganglion Cells in Animal Models of Optic Neuropathies
Biology, 2021 Retinal ganglion cells (RGCs) comprise a heterogenous group of projection neurons that transmit visual information from the retina to the brain. Progressive degeneration of these cells, as it occurs in inflammatory, ischemic, traumatic or glaucomatous ...
Yue Hu +3 more
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Dendritic and axonal targeting patterns of a genetically-specified class of retinal ganglion cells that participate in image-forming circuits. [PDF]
, 2014 BackgroundThere are numerous functional types of retinal ganglion cells (RGCs), each participating in circuits that encode a specific aspect of the visual scene.
Feldheim, David A +6 more
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Large-scale multielectrode recording and stimulation of neural activity [PDF]
, 2007 Large circuits of neurons are employed by the brain to encode and process information. How this encoding and processing is carried out is one of the central questions in neuroscience.
Chichilnisky, E. J. +10 more
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