Advances in retinal ganglion cell imaging [PDF]
Eye, 2015 Glaucoma is one of the leading causes of blindness worldwide and will affect 79.6 million people worldwide by 2020. It is caused by the progressive loss of retinal ganglion cells (RGCs), predominantly via apoptosis, within the retinal nerve fibre layer and the corresponding loss of axons of the optic nerve head.
S I, Balendra +3 more
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Long-term gene therapy causes transgene-specific changes in the morphology of regenerating retinal ganglion cells [PDF]
, 2012 Recombinant adeno-associated viral (rAAV) vectors can be used to introduce neurotrophic genes into injured CNS neurons, promoting survival and axonal regeneration.
Rodger Jennifer +14 more
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Frontiers in Cell and Developmental Biology, 2022 Radiation retinopathy (RR) is a common complication following radiation therapy of globe, head, and neck malignancies, and is characterized by microangiopathy, neuroretinopathy, and the irreversible loss of visual function. To date, there is no effective
Siyu Chen +21 more
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Non-viral delivery and optimized optogenetic stimulation of retinal ganglion cells led to behavioral restoration of vision [PDF]
, 2012 Stimulation of retinal neurons using optogenetics via use of chanelrhodopsin-2 (ChR2) has opened up a new direction for restoration of vision for treatment of retinitis pigmentosa (RP).
Shivaranjani Shivalingaiah +4 more
core +1 more source
Lepidium sativum as candidate against excitotoxicity in retinal ganglion cells
Translational Neuroscience, 2021 Glutamate excitotoxicity is considered one of the major causes of retinal ganglion cell death in many retinal diseases. Retinal ganglion cell degeneration causes severe blindness since visual signals from the eye to the brain are conducted only through ...
Al-Dbass Abeer +7 more
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Adult limbal neurosphere cells: a potential autologous cell resource for retinal cell generation [PDF]
, 2014 The Corneal limbus is a readily accessible region at the front of the eye, separating the cornea and sclera. Neural colonies (neurospheres) can be generated from adult corneal limbus in vitro.
Jessica Cooke (637632) +17 more
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VEGFD Protects Retinal Ganglion Cells and, consequently, Capillaries against Excitotoxic Injury
Molecular Therapy: Methods & Clinical Development, 2020 In the central nervous system, neurons and the vasculature influence each other. While it is well described that a functional vascular system is trophic to neurons and that vascular damage contributes to neurodegeneration, the opposite scenario in which ...
Annabelle Schlüter +4 more
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Glial metabolic alterations during glaucoma pathogenesis
Frontiers in Ophthalmology, 2023 Glaucoma is the leading cause of irreversible blindness. Current treatment options are limited and often only slow disease progression. Metabolic dysfunction has recently been recognized as a key early and persistent mechanism in glaucoma pathophysiology.
Anne Rombaut +3 more
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Cell transplantation to replace retinal ganglion cells faces challenges – the Switchboard Dilemma
Neural Regeneration Research, 2021 The mammalian retina displays incomplete intrinsic regenerative capacities; therefore, retina degeneration is a major cause of irreversible blindness such as glaucoma, age-related macular degeneration and diabetic retinopathy.
Yuan Liu, Richard K Lee
doaj +1 more source
Neurogenesis and Specification of Retinal Ganglion Cells [PDF]
International Journal of Molecular Sciences, 2020 Across all species, retinal ganglion cells (RGCs) are the first retinal neurons generated during development, followed by the other retinal cell types. How are retinal progenitor cells (RPCs) able to produce these cell types in a specific and timely order?
Nguyen-Ba-Charvet, Kim Tuyen +1 more
openaire +3 more sources