Results 21 to 30 of about 60,940 (264)
Assessing retinal ganglion cell damage [PDF]
Eye, 2017 Retinal ganglion cell (RGC) loss is the hallmark of optic neuropathies, including glaucoma, where damage to RGC axons occurs at the level of the optic nerve head. In experimental glaucoma, damage is assessed at the axon level (in the retinal nerve fibre layer and optic nerve head) or at the soma level (in the retina).
C A, Smith, J R, Vianna, B C, Chauhan
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Susceptibility to neurodegeneration in a glaucoma is modified by Bax gene dosage. [PDF]
PLoS Genetics, 2005 In glaucoma, harmful intraocular pressure often contributes to retinal ganglion cell death. It is not clear, however, if intraocular pressure directly insults the retinal ganglion cell axon, the soma, or both.
Richard T Libby +6 more
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Neural Regeneration Research, 2016 Bone marrow mesenchymal stem cells can reduce retinal ganglion cell death and effectively prevent vision loss. Previously, we found that during differentiation, female rhesus monkey bone marrow mesenchymal stem cells acquire a higher neurogenic potential
Jing Yuan, Jian-xiong Yu
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Cell-Based Neuroprotection of Retinal Ganglion Cells in Animal Models of Optic Neuropathies
Biology, 2021 Retinal ganglion cells (RGCs) comprise a heterogenous group of projection neurons that transmit visual information from the retina to the brain. Progressive degeneration of these cells, as it occurs in inflammatory, ischemic, traumatic or glaucomatous ...
Yue Hu +3 more
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Folia Histochemica et Cytobiologica, 2012 Glaucoma is a result of increased intraocular pressure leading to damage to retinal ganglion cells and<br />optic nerve axons. The aim of this study was to evaluate HIF-1 expression in optic nerve axons and retinal<br />ganglion cells in 42 ...
Joanna Reszeć +3 more
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Pluripotent Stem Cell-Based Approaches to Explore and Treat Optic Neuropathies
Frontiers in Neuroscience, 2018 Sight is a major sense for human and visual impairment profoundly affects quality of life, especially retinal degenerative diseases which are the leading cause of irreversible blindness worldwide.
Oriane Rabesandratana +2 more
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Brazilian Journal of Medical and Biological Research, 2005 Exclusion of the transcription factor Max from the nucleus of retinal ganglion cells is an early, caspase-independent event of programmed cell death following damage to the optic axons.
H. Petrs-Silva +4 more
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Scientific Reports, 2021 Optic neuropathies such as glaucoma are characterized by retinal ganglion cell (RGC) degeneration and death. The sigma-1 receptor (S1R) is an attractive target for treating optic neuropathies as it is highly expressed in RGCs, and its absence causes ...
Michal Geva +7 more
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Frontiers in Molecular Biosciences, 2022 Although mutations in ADAMTS10 have long been known to cause autosomal recessive Weill-Marchesani Syndrome which is characterized by short stature and ocular abnormalities, more recent work has shown that certain mutations in ADAMTS10 cause glaucoma in ...
Lauren K. Wareham +8 more
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Neurogenesis and Specification of Retinal Ganglion Cells [PDF]
International Journal of Molecular Sciences, 2020 Across all species, retinal ganglion cells (RGCs) are the first retinal neurons generated during development, followed by the other retinal cell types. How are retinal progenitor cells (RPCs) able to produce these cell types in a specific and timely order?
Nguyen-Ba-Charvet, Kim Tuyen +1 more
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