Results 41 to 50 of about 109,464 (277)

R-28 cell-derived extracellular vesicles protect retinal ganglion cells in glaucoma

Neural Regeneration Research
Glaucoma is characterized by chronic progressive optic nerve damage and retinal ganglion cell death. Although extensive research has been conducted on neuroprotection for retinal ganglion cells, there is still no treatment for clinical use.
Esmahan Durmaz, Maryam Esmaeili, Philip Lewis, Gloria Cimaglia, Aled Clayton, Ben Mead   +5 more
doaj   +1 more source

Spatially and Temporally Regulated NRF2 Gene Therapy Using Mcp-1 Promoter in Retinal Ganglion Cell Injury

Molecular Therapy: Methods & Clinical Development, 2017
Retinal ganglion cell degeneration triggered by axonal injury is believed to underlie many ocular diseases, including glaucoma and optic neuritis. In these diseases, retinal ganglion cells are affected unevenly, both spatially and temporally, such that ...
Kosuke Fujita, Koji M. Nishiguchi, Yukihiro Shiga, Toru Nakazawa   +3 more
doaj   +1 more source

Advances in retinal ganglion cell imaging [PDF]

Eye, 2015
Glaucoma is one of the leading causes of blindness worldwide and will affect 79.6 million people worldwide by 2020. It is caused by the progressive loss of retinal ganglion cells (RGCs), predominantly via apoptosis, within the retinal nerve fibre layer and the corresponding loss of axons of the optic nerve head.
S I, Balendra, E M, Normando, P A, Bloom, M F, Cordeiro   +3 more
openaire   +2 more sources

Digestion of the glycosaminoglycan extracellular matrix by chondroitinase ABC supports retinal ganglion cell dendritic preservation in a rodent model of experimental glaucoma

Molecular Brain, 2018
Retinal ganglion cell dendritic atrophy is an early feature of glaucoma, and the recovery of retinal ganglion cell dendrites is a viable option for vision improvement in glaucoma.
James R. Tribble, Pete A. Williams, Bruce Caterson, Frank Sengpiel, James E. Morgan   +4 more
doaj   +1 more source

Stem Cells, Retinal Ganglion Cells and Glaucoma [PDF]

, 2014
Retinal ganglion cells (RGCs) represent an essential neuronal cell type for vision. These cells receive inputs from light-sensing photoreceptors via retinal interneurons and then relay these signals to the brain for further processing. RGC diseases that result in cell death, e.g.
Valentin M, Sluch, Donald J, Zack
openaire   +2 more sources

c-Jun N-terminal kinase 3 expression in the retina of ocular hypertension mice: a possible target to reduce ganglion cell apoptosis

Neural Regeneration Research, 2015
Glaucoma, a type of optic neuropathy, is characterized by the loss of retinal ganglion cells. It remains controversial whether c-Jun N-terminal kinase (JNK) participates in the apoptosis of retinal ganglion cells in glaucoma. This study sought to explore
Yue He, Jie Chen, Shu-guang Zhang, Yuan-sheng Yuan, Yan Li, Hong-bin Lv, Jin-hua Gan   +6 more
doaj   +1 more source

Comparison of AAV-Mediated Optogenetic Vision Restoration between Retinal Ganglion Cell Expression and ON Bipolar Cell Targeting

Molecular Therapy: Methods & Clinical Development, 2020
The loss of photoreceptors in individuals with retinal degenerative diseases leads to partial or complete blindness. Optogenetic therapy is a promising approach for restoring vision to the blind.
Qi Lu, Tushar H. Ganjawala, Andrea Krstevski, Gary W. Abrams, Zhuo-Hua Pan   +4 more
doaj   +1 more source

Retinal Processing: Insights from Mathematical Modelling

Journal of Imaging, 2022
The retina is the entrance of the visual system. Although based on common biophysical principles, the dynamics of retinal neurons are quite different from their cortical counterparts, raising interesting problems for modellers.
Bruno Cessac
doaj   +1 more source

Nel positively regulates the genesis of retinal ganglion cells by promoting their differentiation and survival during development [PDF]

, 2014
Peer reviewedPublisher ...
Adams JC, Agathocleous M, Aihara K, Amy S. Findlay, Austin CP, Cayouette M, Cepko CL, Chizu Nakamoto, de Iongh R, Ehrlich D, Elaine Durward, Ewa D. Zakrzewska, Fekete DM, Flanagan JG, Frade JM, Galvez JM, Hansen MJ, Harada H, Harpavat S, Hashimoto T, Holt CE, Hu WY, Isenmann S, Jablonski MM, Jablonski MM, Jiang Y, Jiang Y, Katahira T, Koga A, Kuroda S, Layer PG, Marianne Bronner, Martinez-Morales JR, Masai I, Masaru Nakamoto, Matsuhashi S, Matsuhashi S, Matsuoka H, Matsuyama S, Matsuyama S, McCabe KL, McCabe KL, McLaughlin T, Moore SW, Munemasa Y, Nakamura R, Nelson BR, Nelson BR, Oyasu M, Patel A, Prada C, Price J, Rachel RA, Raymond SM, Sato Y, Snow RL, Soh-Leh Kuan, Stiemke MM, Strauss O, Takuma Endo, Wang JT, Watanabe TK, Wetts R, Xiang M, Yee JK, Zhang XM, Zhang XM, Zhufeng Ouyang   +67 more
core   +1 more source

Encoding surprise by retinal ganglion cells

PLOS Computational Biology, 2022
The efficient coding hypothesis posits that early sensory neurons transmit maximal information about sensory stimuli, given internal constraints. A central prediction of this theory is that neurons should preferentially encode stimuli that are most surprising.
Danica Despotović, Corentin Joffrois, Olivier Marre, Matthew Chalk   +3 more
openaire   +3 more sources