Results 41 to 50 of about 15,573 (263)

PANoptosis of Retinal Ganglion Cells

Journal of Integrative Neuroscience
PANoptosis represents a novel form of programmed cell death regulated and controlled by the PANoptosome. It encompasses the essential features of apoptosis, necroptosis, and pyroptosis and combines elements from each process. PANoptosis contributes to the development of various diseases, including bacterial and viral infections, tumors, inflammatory ...
Xuejing Lu, Qiaoqiao Kong, Wenjia Qu, Yixiang Jiang   +3 more
openaire   +2 more sources

Molecular Phenotyping of Retinal Ganglion Cells [PDF]

The Journal of Neuroscience, 2002
Classifying all of the ganglion cells in the mammalian retina has long been a goal of anatomists, physiologists, and cell biologists. The rabbit retinal ganglion cell layer was phenotyped using intrinsic small molecule signals (aspartate, glutamate, glycine, glutamine, GABA, and taurine) and glutamate receptor-gated 1-amino-4-guanidobutane excitation ...
Robert E, Marc, Bryan W, Jones
openaire   +2 more sources

c-Jun N-terminal kinase 3 expression in the retina of ocular hypertension mice: a possible target to reduce ganglion cell apoptosis

Neural Regeneration Research, 2015
Glaucoma, a type of optic neuropathy, is characterized by the loss of retinal ganglion cells. It remains controversial whether c-Jun N-terminal kinase (JNK) participates in the apoptosis of retinal ganglion cells in glaucoma. This study sought to explore
Yue He, Jie Chen, Shu-guang Zhang, Yuan-sheng Yuan, Yan Li, Hong-bin Lv, Jin-hua Gan   +6 more
doaj   +1 more source

Comparison of AAV-Mediated Optogenetic Vision Restoration between Retinal Ganglion Cell Expression and ON Bipolar Cell Targeting

Molecular Therapy: Methods & Clinical Development, 2020
The loss of photoreceptors in individuals with retinal degenerative diseases leads to partial or complete blindness. Optogenetic therapy is a promising approach for restoring vision to the blind.
Qi Lu, Tushar H. Ganjawala, Andrea Krstevski, Gary W. Abrams, Zhuo-Hua Pan   +4 more
doaj   +1 more source

Retinal Processing: Insights from Mathematical Modelling

Journal of Imaging, 2022
The retina is the entrance of the visual system. Although based on common biophysical principles, the dynamics of retinal neurons are quite different from their cortical counterparts, raising interesting problems for modellers.
Bruno Cessac
doaj   +1 more source

Retinal ganglion cells: dying to survive

The International Journal of Developmental Biology, 2006
This review examines the maturation of the retinal ganglion cell (RGC) population within the nascent retina. Apoptosis, a form of programmed cell death prevalent throughout the developing central nervous system (CNS), is evident in the growth of RGCs within the ganglion cell layer.
Marc B, Guerin, Declan P, McKernan, Colm J, O'Brien, Thomas G, Cotter   +3 more
openaire   +3 more sources

On the Generation and Regeneration of Retinal Ganglion Cells [PDF]

Frontiers in Cell and Developmental Biology, 2020
Retinal development follows a conserved neurogenic program in vertebrates to orchestrate the generation of specific cell types from multipotent progenitors in sequential but overlapping waves. In this program, retinal ganglion cells (RGCs) are the first cell type generated.
Viviane M. Oliveira-Valença, Alejandra Bosco, Monica L. Vetter, Mariana S. Silveira, Mariana S. Silveira   +4 more
openaire   +4 more sources

Adult limbal neurosphere cells: a potential autologous cell resource for retinal cell generation

, 2014
The Corneal limbus is a readily accessible region at the front of the eye, separating the cornea and sclera. Neural colonies (neurospheres) can be generated from adult corneal limbus in vitro.
Jessica Cooke (637632), Jennifer Scott, Heather Thomson, Xiaoli Chen, Lotery, Andrew J., Xiaoli Chen (102563), Cooke, J.J., Scott, Jennifer A., Andrew Lotery, Heather Thomson (637631), Thomson, Heather, Jessica Cooke, Parwez Hossain, Jennifer Scott (637633), Chen, Xiaoli, Hossain, Parwez, Andrew Lotery (637635), Parwez Hossain (637634)   +17 more
core   +1 more source

Damage and repair in retinal degenerative diseases: Molecular basis through clinical translation

Neural Regeneration Research
Retinal ganglion cells are the bridging neurons between the eye and the central nervous system, transmitting visual signals to the brain. The injury and loss of retinal ganglion cells are the primary pathological changes in several retinal degenerative ...
Ziting Zhang, Junfeng Ma, Wahid Shah, Xin Quan, Tao Ding, Yuan Gao   +5 more
doaj   +1 more source

Valproate reduces retinal ganglion cell apoptosis in rats after optic nerve crush

Neural Regeneration Research, 2023
The retinal ganglion cells of the optic nerve have a limited capacity for self-repair after injury. Valproate is a histone deacetylase inhibitor and multitarget drug, which has been demonstrated to protect retinal neurons.
Feng Pan, Dan Hu, Li-Juan Sun, Qian Bai, Yu-Sheng Wang, Xu Hou   +5 more
doaj   +1 more source