Results 51 to 60 of about 109,464 (277)

Damage and repair in retinal degenerative diseases: Molecular basis through clinical translation

Neural Regeneration Research
Retinal ganglion cells are the bridging neurons between the eye and the central nervous system, transmitting visual signals to the brain. The injury and loss of retinal ganglion cells are the primary pathological changes in several retinal degenerative ...
Ziting Zhang, Junfeng Ma, Wahid Shah, Xin Quan, Tao Ding, Yuan Gao   +5 more
doaj   +1 more source

Valproate reduces retinal ganglion cell apoptosis in rats after optic nerve crush

Neural Regeneration Research, 2023
The retinal ganglion cells of the optic nerve have a limited capacity for self-repair after injury. Valproate is a histone deacetylase inhibitor and multitarget drug, which has been demonstrated to protect retinal neurons.
Feng Pan, Dan Hu, Li-Juan Sun, Qian Bai, Yu-Sheng Wang, Xu Hou   +5 more
doaj   +1 more source

The role of lipid metabolism in neuronal senescence

FEBS Open Bio, EarlyView.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari, Eleftheria Panagiotidou, Nektarios Tavernarakis   +2 more
wiley   +1 more source

Single-cell RNA sequencing analysis of the retina under acute high intraocular pressure

Neural Regeneration Research
High intraocular pressure causes retinal ganglion cell injury in primary and secondary glaucoma diseases, yet the molecular landscape characteristics of retinal cells under high intraocular pressure remain unknown. Rat models of acute hypertension ocular
Shaojun Wang, Siti Tong, Xin Jin, Na Li, Pingxiu Dang, Yang Sui, Ying Liu, Dajiang Wang   +7 more
doaj   +1 more source

Permissive role for mGlu1 metabotropic glutamate receptors in excitotoxic retinal degeneration [PDF]

, 2017
Neuroprotection is an unmet need in eye disorders characterized by retinal ganglion cell (RGC) death, such as prematurity-induced retinal degeneration, glaucoma, and age-related macular degeneration.
Battaglia, Giuseppe, Beneventano, Martina, Bruno, Valeria, Bucci, Domenico, Di Pietro, Paola, Liberatore, Francesca, Madonna, Michele, Mascio, Giada, Nicoletti, Ferdinando, Puliti, Alda Maria, Romano, Maria Rosaria   +10 more
core   +1 more source

Otx2 stimulates adult retinal ganglion cell regeneration [PDF]

Neural Regeneration Research, 2020
AbstractRetinal ganglion cell axons provide the only link between the light sensitive and photon transducing neural retina and visual centers of the brain. Retinal ganglion cell axon degeneration occurs in a number of blinding diseases and the ability to stimulate axon regeneration from surviving ganglion cells could provide the anatomic substrate for ...
Ibad, Raoul Torero, Quenech’du, Nicole, Prochiantz, Alain, Moya, Kenneth   +3 more
openaire   +3 more sources

Paramagnetic Rim Lesions Are Associated With Trans‐Synaptic Degeneration of the Visual Pathway in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Retrograde trans‐synaptic degeneration (rTSD) from posterior visual pathway lesions in multiple sclerosis (MS) is characterized by hemi‐macular ganglion cell‐inner plexiform layer (GCIPL) thinning and contralateral visual field loss.
Abdul Jaber Tayem, Angel Liu, Sargis Manukyan, Mustafa Subhi, Elaina Luskin, Bryan Quah, Sreekanth Madhusoodhanan Nair, Arzu C. Has Silemek, Gabriela Zabala, Yujie Cui, Laura Locke, Paula Barreras, Marwa Kaisey, Vinicius Calsavara, Daniel S. Reich, Nancy L. Sicotte, Pascal Sati, Omar Al‐Louzi   +17 more
wiley   +1 more source

Retinal Ganglion Cell Death

, 2011
1.1 Topographic and cellular organization of the retina The retina is the thin (0.2 mm) lining of the back of the eye that gathers light focused on it by the cornea and lens. The retina has a complex laminar organization; cells are organized into layers (Fig. 1). These layers are named by reference to the middle of the eyeball; the innermost layers are
Yasemin Budak, Muberra Akdog
openaire   +4 more sources

Spatial distribution of excitatory synapses on the dendrites of ganglion cells in the mouse retina. [PDF]

PLoS ONE, 2014
Excitatory glutamatergic inputs from bipolar cells affect the physiological properties of ganglion cells in the mammalian retina. The spatial distribution of these excitatory synapses on the dendrites of retinal ganglion cells thus may shape their ...
Yin-Peng Chen, Chuan-Chin Chiao
doaj   +1 more source

An in vivo evaluation of Brilliant Blue G in animals and humans [PDF]

, 2008
Background/Aims: To evaluate the retinal toxicity of Brilliant Blue G (BBG) following intravitreal injection in rat eyes and examine the biocompatibility and the staining properties in humans.Methods: BBG was injected into the 11 rat eyes to evaluate ...
Fiedorowicz, M., Grüterich, Martin, Haritoglou, Christos, Kampik, Anselm, May, C. A., Nentwich, Martin M., Priglinger, Siegfried G., Remy, M., Schuettauf, F., Schumann, Ricarda G., Thaler, S.   +10 more
core   +1 more source