Results 11 to 20 of about 15,573 (263)

Uptake of Retrograde Tracers by Intact Optic Nerve Axons: A New Way to Label Retinal Ganglion Cells. [PDF]

PLoS ONE, 2015
Retrograde labelling of retinal ganglion cells with optic nerve transection often leads to degeneration of ganglion cells in prolonged experiments. Here we report that an intact optic nerve could uptake retrograde tracers applied onto the surface of the ...
Yu-Xiang Liang, Jian Yang, Ti-Fei Yuan, Kwok-Fai So   +3 more
doaj   +1 more source

Human Umbilical Cord Blood-Derived CD133+CD34+ Cells Protect Retinal Endothelial Cells and Ganglion Cells in X-Irradiated Rats through Angioprotective and Neurotrophic Factors

Frontiers in Cell and Developmental Biology, 2022
Radiation retinopathy (RR) is a common complication following radiation therapy of globe, head, and neck malignancies, and is characterized by microangiopathy, neuroretinopathy, and the irreversible loss of visual function. To date, there is no effective
Siyu Chen, Siyu Chen, Minghui Li, Minghui Li, Jianguo Sun, Dan Wang, Chuanhuang Weng, Chuanhuang Weng, Yuxiao Zeng, Yuxiao Zeng, Yijian Li, Yijian Li, Shujia Huo, Shujia Huo, Xiaona Huang, Xiaona Huang, Shiying Li, Shiying Li, Ting Zou, Ting Zou, Haiwei Xu, Haiwei Xu   +21 more
doaj   +1 more source

Lepidium sativum as candidate against excitotoxicity in retinal ganglion cells

Translational Neuroscience, 2021
Glutamate excitotoxicity is considered one of the major causes of retinal ganglion cell death in many retinal diseases. Retinal ganglion cell degeneration causes severe blindness since visual signals from the eye to the brain are conducted only through ...
Al-Dbass Abeer, Amina Musarat, Al Musayeib Nawal M., El-Anssary Amira A., Bhat Ramesa Shafi, Fahmy Rania, Alhamdan Majd M., El-Ansary Afaf   +7 more
doaj   +1 more source

Targeting retinal ganglion cell recovery [PDF]

Eye, 2017
Accumulating evidence from experimental and clinical studies suggest that retinal ganglion cells at least in the earlier stages of glaucoma have the capacity to recover function following periods of functional loss. The capacity for recovery may be negatively impacted by advancing age but can be boosted by interventions such as diet restriction and ...
J G, Crowston, E T, Fahy, L, Fry, I A, Trounce, P, van Wijngaarden, S, Petrou, V, Chrysostomou   +6 more
openaire   +2 more sources

Advances in retinal ganglion cell imaging [PDF]

Eye, 2015
Glaucoma is one of the leading causes of blindness worldwide and will affect 79.6 million people worldwide by 2020. It is caused by the progressive loss of retinal ganglion cells (RGCs), predominantly via apoptosis, within the retinal nerve fibre layer and the corresponding loss of axons of the optic nerve head.
S I, Balendra, E M, Normando, P A, Bloom, M F, Cordeiro   +3 more
openaire   +2 more sources

Glial metabolic alterations during glaucoma pathogenesis

Frontiers in Ophthalmology, 2023
Glaucoma is the leading cause of irreversible blindness. Current treatment options are limited and often only slow disease progression. Metabolic dysfunction has recently been recognized as a key early and persistent mechanism in glaucoma pathophysiology.
Anne Rombaut, Rune Brautaset, Pete A. Williams, James R. Tribble   +3 more
doaj   +1 more source

Assessing retinal ganglion cell damage [PDF]

Eye, 2017
Retinal ganglion cell (RGC) loss is the hallmark of optic neuropathies, including glaucoma, where damage to RGC axons occurs at the level of the optic nerve head. In experimental glaucoma, damage is assessed at the axon level (in the retinal nerve fibre layer and optic nerve head) or at the soma level (in the retina).
C A, Smith, J R, Vianna, B C, Chauhan
openaire   +2 more sources

VEGFD Protects Retinal Ganglion Cells and, consequently, Capillaries against Excitotoxic Injury

Molecular Therapy: Methods & Clinical Development, 2020
In the central nervous system, neurons and the vasculature influence each other. While it is well described that a functional vascular system is trophic to neurons and that vascular damage contributes to neurodegeneration, the opposite scenario in which ...
Annabelle Schlüter, Bahar Aksan, Ricarda Diem, Richard Fairless, Daniela Mauceri   +4 more
doaj   +1 more source

Activation of BMP-Smad1/5/8 signaling promotes survival of retinal ganglion cells after damage in vivo. [PDF]

PLoS ONE, 2012
While the essential role of bone morphogenetic protein (BMP) signaling in nervous system development is well established, its function in the adult CNS is poorly understood.
Yumi Ueki, Thomas A Reh
doaj   +1 more source

Cell transplantation to replace retinal ganglion cells faces challenges – the Switchboard Dilemma

Neural Regeneration Research, 2021
The mammalian retina displays incomplete intrinsic regenerative capacities; therefore, retina degeneration is a major cause of irreversible blindness such as glaucoma, age-related macular degeneration and diabetic retinopathy.
Yuan Liu, Richard K Lee
doaj   +1 more source