Results 11 to 20 of about 60,940 (264)
Intrinsically Photosensitive Retinal Ganglion Cells [PDF]
Science China Life Sciences, 2010 A new mammalian photoreceptor was recently discovered to reside in the ganglion cell layer of the inner retina. These intrinsically photosensitive retinal ganglion cells (ipRGCs) express a photopigment, melanopsin that confers upon them the ability to respond to light in the absence of all rod and cone photoreceptor input.
Pickard, Gary E., Sollars, Patricia J.
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Protecting retinal ganglion cells [PDF]
Eye, 2017 Retinal ganglion cell degeneration underlies several conditions which give rise to significant visual compromise, including glaucoma, hereditary optic neuropathies, ischaemic optic neuropathies, and demyelinating disease. In this review, we discuss the emerging strategies for neuroprotection specifically in the context of glaucoma, including ...
T Z, Khatib, K R, Martin
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Retinal ganglion cells in diabetes [PDF]
The Journal of Physiology, 2008 Diabetic retinopathy has long been recognized as a vascular disease that develops in most patients, and it was believed that the visual dysfunction that develops in some diabetics was due to the vascular lesions used to characterize the disease. It is becoming increasingly clear that neuronal cells of the retina also are affected by diabetes, resulting
Timothy S, Kern, Alistair J, Barber
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Glial metabolic alterations during glaucoma pathogenesis
Frontiers in Ophthalmology, 2023 Glaucoma is the leading cause of irreversible blindness. Current treatment options are limited and often only slow disease progression. Metabolic dysfunction has recently been recognized as a key early and persistent mechanism in glaucoma pathophysiology.
Anne Rombaut +3 more
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VEGFD Protects Retinal Ganglion Cells and, consequently, Capillaries against Excitotoxic Injury
Molecular Therapy: Methods & Clinical Development, 2020 In the central nervous system, neurons and the vasculature influence each other. While it is well described that a functional vascular system is trophic to neurons and that vascular damage contributes to neurodegeneration, the opposite scenario in which ...
Annabelle Schlüter +4 more
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Targeting retinal ganglion cell recovery [PDF]
Eye, 2017 Accumulating evidence from experimental and clinical studies suggest that retinal ganglion cells at least in the earlier stages of glaucoma have the capacity to recover function following periods of functional loss. The capacity for recovery may be negatively impacted by advancing age but can be boosted by interventions such as diet restriction and ...
J G, Crowston +6 more
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Activation of BMP-Smad1/5/8 signaling promotes survival of retinal ganglion cells after damage in vivo. [PDF]
PLoS ONE, 2012 While the essential role of bone morphogenetic protein (BMP) signaling in nervous system development is well established, its function in the adult CNS is poorly understood.
Yumi Ueki, Thomas A Reh
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Cell transplantation to replace retinal ganglion cells faces challenges – the Switchboard Dilemma
Neural Regeneration Research, 2021 The mammalian retina displays incomplete intrinsic regenerative capacities; therefore, retina degeneration is a major cause of irreversible blindness such as glaucoma, age-related macular degeneration and diabetic retinopathy.
Yuan Liu, Richard K Lee
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Advances in retinal ganglion cell imaging [PDF]
Eye, 2015 Glaucoma is one of the leading causes of blindness worldwide and will affect 79.6 million people worldwide by 2020. It is caused by the progressive loss of retinal ganglion cells (RGCs), predominantly via apoptosis, within the retinal nerve fibre layer and the corresponding loss of axons of the optic nerve head.
S I, Balendra +3 more
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Hyperactivity of ON-type retinal ganglion cells in streptozotocin-induced diabetic mice. [PDF]
PLoS ONE, 2013 Impairment of visual function has been detected in the early stage of diabetes but the underlying neural mechanisms involved are largely unknown.
Jun Yu +5 more
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