Results 11 to 20 of about 109,464 (277)

Intrinsically Photosensitive Retinal Ganglion Cells [PDF]

Science China Life Sciences, 2010
A new mammalian photoreceptor was recently discovered to reside in the ganglion cell layer of the inner retina. These intrinsically photosensitive retinal ganglion cells (ipRGCs) express a photopigment, melanopsin that confers upon them the ability to respond to light in the absence of all rod and cone photoreceptor input.
Pickard, Gary E., Sollars, Patricia J.
openaire   +6 more sources

Protecting retinal ganglion cells [PDF]

Eye, 2017
Retinal ganglion cell degeneration underlies several conditions which give rise to significant visual compromise, including glaucoma, hereditary optic neuropathies, ischaemic optic neuropathies, and demyelinating disease. In this review, we discuss the emerging strategies for neuroprotection specifically in the context of glaucoma, including ...
T Z, Khatib, K R, Martin
openaire   +2 more sources

Retinal ganglion cells in diabetes [PDF]

The Journal of Physiology, 2008
Diabetic retinopathy has long been recognized as a vascular disease that develops in most patients, and it was believed that the visual dysfunction that develops in some diabetics was due to the vascular lesions used to characterize the disease. It is becoming increasingly clear that neuronal cells of the retina also are affected by diabetes, resulting
Timothy S, Kern, Alistair J, Barber
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Targeting retinal ganglion cell recovery [PDF]

Eye, 2017
Accumulating evidence from experimental and clinical studies suggest that retinal ganglion cells at least in the earlier stages of glaucoma have the capacity to recover function following periods of functional loss. The capacity for recovery may be negatively impacted by advancing age but can be boosted by interventions such as diet restriction and ...
J G, Crowston, E T, Fahy, L, Fry, I A, Trounce, P, van Wijngaarden, S, Petrou, V, Chrysostomou   +6 more
openaire   +2 more sources

Assessing retinal ganglion cell damage [PDF]

Eye, 2017
Retinal ganglion cell (RGC) loss is the hallmark of optic neuropathies, including glaucoma, where damage to RGC axons occurs at the level of the optic nerve head. In experimental glaucoma, damage is assessed at the axon level (in the retinal nerve fibre layer and optic nerve head) or at the soma level (in the retina).
C A, Smith, J R, Vianna, B C, Chauhan
openaire   +2 more sources

Lepidium sativum as candidate against excitotoxicity in retinal ganglion cells

Translational Neuroscience, 2021
Glutamate excitotoxicity is considered one of the major causes of retinal ganglion cell death in many retinal diseases. Retinal ganglion cell degeneration causes severe blindness since visual signals from the eye to the brain are conducted only through ...
Al-Dbass Abeer, Amina Musarat, Al Musayeib Nawal M., El-Anssary Amira A., Bhat Ramesa Shafi, Fahmy Rania, Alhamdan Majd M., El-Ansary Afaf   +7 more
doaj   +1 more source

General features of the retinal connectome determine the computation of motion anticipation [PDF]

, 2015
Motion anticipation allows the visual system to compensate for the slow speed of phototransduction so that a moving object can be accurately located.
Asari, Baylor, Berry, Bischofberger, Blitz, Bollmann, Bonin, Borst, Branco, Branco, Briggman, Bölinger, Cafaro, Calkins, Calkins, Chen, Demb, Dreosti, Esposti, Freed, Gleeson, Gollisch, Goodale, Gouras, Haider, Hao, Hausselt, Haverkamp, Helmstaedter, Hines, Hitchcock, HUBEL, Isaacson, Jakobs, Jarsky, Johnston, Koch, Koizumi, Kolb, Kolb, Kolb, Koontz, Kuzmiski, Lee, Leonardo, Levick, Liu, London, Lukasiewicz, MacNeil, Magee, Malpeli, Manookin, Marshak, Marshak, Masland, Miller, Münch, Nikolaev, Odermatt, Oesch, Olveczky, Owczarzak, Pouille, Quiroga, RALL, Rieke, Roska, Schachter, Schwartz, Schwartz, Sivyer, Smith, Talbot, Tanaka, Taylor, Trenholm, Weber, West, Xu, Yonehara, Zhu   +81 more
core   +2 more sources

Non-viral delivery and optimized optogenetic stimulation of retinal ganglion cells led to behavioral restoration of vision [PDF]

, 2012
Stimulation of retinal neurons using optogenetics via use of chanelrhodopsin-2 (ChR2) has opened up a new direction for restoration of vision for treatment of retinitis pigmentosa (RP).
Edward Wong, Ling Gu, Mathew Ficinski, Samarendra Mohanty, Samarendra Mohanty, Shivaranjani Shivalingaiah   +5 more
core   +2 more sources

Glial metabolic alterations during glaucoma pathogenesis

Frontiers in Ophthalmology, 2023
Glaucoma is the leading cause of irreversible blindness. Current treatment options are limited and often only slow disease progression. Metabolic dysfunction has recently been recognized as a key early and persistent mechanism in glaucoma pathophysiology.
Anne Rombaut, Rune Brautaset, Pete A. Williams, James R. Tribble   +3 more
doaj   +1 more source

VEGFD Protects Retinal Ganglion Cells and, consequently, Capillaries against Excitotoxic Injury

Molecular Therapy: Methods & Clinical Development, 2020
In the central nervous system, neurons and the vasculature influence each other. While it is well described that a functional vascular system is trophic to neurons and that vascular damage contributes to neurodegeneration, the opposite scenario in which ...
Annabelle Schlüter, Bahar Aksan, Ricarda Diem, Richard Fairless, Daniela Mauceri   +4 more
doaj   +1 more source