Results 141 to 150 of about 385,405 (300)

Continuous Suppression of Pathological Retinal and Choroidal Neovascularization in Cynomolgus Monkeys via Noninvasive Ophthalmic Delivery of a Novel Anti‐VEGFA Nanobody and Proprietary Penetratin Analog Formulation

Advanced Science, Volume 13, Issue 1, 5 January 2026.
Pathological retinal/choroidal neovascularization drives vision loss in DR and AMD. Current anti‐VEGF injections, while effective, require invasive, frequent administration. Pene/LQ015, is developed a novel topical anti‐VEGFA nanobody formulation achieving therapeutic intraocular levels through penetratin analog‐enhanced delivery.
Chong Chen, Min Zhu, Xingyan Fan, Kangjia Lv, Kuan Jiang, Yuchen Zhang, Haoliang Zhang, Xinming Qi, Benjamin TK Lee, Yakun Wan, Gang Wei, Kun Liu, Xun Xu   +12 more
wiley   +1 more source

Circular RNAs as Biomarkers and Therapeutic Targets in Diabetic Cardiovascular Complications

Endocrinology, Diabetes &Metabolism, Volume 9, Issue 1, January 2026.
This graphic abstract elaborates on the recent mechanism of circular RNAs (circRNAs) in the pathogenesis, diagnosis and treatment of diabetic cardiovascular complications. Diabetes mellitus induces oxidative/inflammatory stress, followed by endothelial dysfunction and leads to micro‐/macro‐vascular complications.
Shreya Singh Beniwal, Yujin Jeong, Akash Rawat, Mahmoud Einieh, Kashyapi Patil, Rafael Everton Assunção Ribeiro da Costa, Pulkit Saini, Kamal Yousef Ghazal, Abhijeet Kumar, Ayush Dwivedi, Anuja Anil Mandavkar   +10 more
wiley   +1 more source

Suppression of Retinal Neovascularization by Lentivirus-Mediated Netrin-1 Small Hairpin RNA [PDF]

, 2011
Huizhuo Xu, Jiaolian Liu, Siqi Xiong, Yun-Zheng Le, Xiaobo Xia   +4 more
openalex   +1 more source

Mass spectrometry in ocular drug research

Mass Spectrometry Reviews, Volume 45, Issue 1, Page 37-68, January/February 2026.
Abstract Mass spectrometry (MS) has been proven as an excellent tool in ocular drug research allowing analyzes from small samples and low concentrations. This review begins with a short introduction to eye physiology and ocular pharmacokinetics and the relevance of advancing ophthalmic treatments.
Eva M. del Amo, Kati‐Sisko Vellonen, Arto Urtti, Tetsuya Terasaki, Anam Hammid, Paavo Honkakoski, Seppo Auriola   +6 more
wiley   +1 more source

Transcriptional Comparison of Human and Murine Retinal Neovascularization. [PDF]

Invest Ophthalmol Vis Sci, 2023
Pauleikhoff L, Boneva S, Boeck M, Schlecht A, Schlunck G, Agostini H, Lange C, Wolf J.   +7 more
europepmc   +1 more source

Association Between Vitamin D Deficiency and the Risk of Diabetic Retinopathy in Patients With Type 2 Diabetes: A Meta‐Analysis

Molecular Genetics &Genomic Medicine, Volume 14, Issue 1, January 2026.
Meta‐analysis of 20 studies (N = 22,408 T2DM patients). Vitamin D deficiency (25[OH]D < 20 ng/mL) associated with 17% higher DR risk: Pooled OR = 1.17, 95% CI: 1.08–1.27, p < 0.001. Mechanistic link: vitamin D regulates retinal inflammation, VEGF suppression, and endothelial protection.
Guoxiao Yu, Chanyuan Cao, Xupeng Shu, Li Yao   +3 more
wiley   +1 more source

Hydrogel Microspheres for Biomedical Applications

Small Science, Volume 6, Issue 1, January 2026.
Hydrogel microspheres (HMs) play pivotal roles in biomedical applications, such as drug delivery, cell culture, regenerative medicine, wound healing, and tumor immunity. This review focuses on the latest findings to provide a more comprehensive understanding of HMs for biomedical applications.
Yingkang Huang, Xi Zhu, Jinhong Zhou, Henan Li, Wei Zhang, Danyang Shen, Ziyan Huang, Tianbo Zhang, Lin Zhuang, Lei Qin, Xiaofeng Xue, Yunjie Lu   +11 more
wiley   +1 more source

AAV2-antiVEGFscFv gene therapy for retinal neovascularization. [PDF]

Mol Ther Methods Clin Dev, 2023
Han N, Xu X, Liu Y, Luo G.
europepmc   +1 more source

Metabolic Syndrome Triggered by High-Fructose Diet Favors Choroidal Neovascularization and Impairs Retinal Light Sensitivity in the Rat

, 2014
Magalie Thierry, Bruno Pasquis, Niyazi Acar, Stéphane Gregoire, Valérie Febvret, Bénédicte Buteau, Ségolène Gambert-Nicot, Alain M. Bron, Catherine Creuzot‐Garcher, Lionel Brétillon   +9 more
openalex   +2 more sources

Advances in Deep Learning Applications for Choroidal Images Analysis: A Narrative Review

IET Image Processing, Volume 20, Issue 1, January/December 2026.
Clinical detection and evaluation of the choroid primarily rely on imaging and subsequent image analysis. The application of artificial intelligence (AI), particularly deep learning (DL), in the analysis of choroidal images shows significant potential for improving accuracy and efficiency.
Yiwen Shi, Zixuan Jiang, Ziyi Yang, Houjin Chen, Xuemin Li, Jiarui Yang   +5 more
wiley   +1 more source