Results 31 to 40 of about 371,429 (272)

Inhibiting NF-κB Signaling Activation Reduces Retinal Neovascularization by Promoting a Polarization Shift in Macrophages

Investigative Ophthalmology and Visual Science, 2020
Purpose Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) signaling is involved in regulating tumor angiogenesis and metastasis; however, the exact mechanism of action in retinal neovascularization (RNV) remains unclear.
Ailing Sui, Xiuping Chen, A. Demetriades, Jikui Shen, Yujuan Cai, Yiyun Yao, Yixuan Yao, Yanji Zhu, Xi Shen, B. Xie   +9 more
semanticscholar   +1 more source

Mass spectrometry in ocular drug research

Mass Spectrometry Reviews, EarlyView., 2023
Abstract Mass spectrometry (MS) has been proven as an excellent tool in ocular drug research allowing analyzes from small samples and low concentrations. This review begins with a short introduction to eye physiology and ocular pharmacokinetics and the relevance of advancing ophthalmic treatments.
Eva M. del Amo, Kati‐Sisko Vellonen, Arto Urtti, Tetsuya Terasaki, Anam Hammid, Paavo Honkakoski, Seppo Auriola   +6 more
wiley   +1 more source

MicroRNA-409-5p promotes retinal neovascularization in diabetic retinopathy

Cell Cycle, 2020
Background: Retinal neovascularization, which is characterized by the increased proliferation, migration, and tube formation of retinal microvascular endothelial cells (RMECs), contributes to the progression of diabetic retinopathy (DR).
Ying Wang, Wenwen Lin, Jianghua Ju
semanticscholar   +1 more source

CNTF Prevents Development of Outer Retinal Neovascularization Through Upregulation of CxCl10

Investigative Ophthalmology and Visual Science, 2020
Purpose Ciliary neurotrophic factor (CNTF) is a well-characterized neurotrophic factor currently in clinical trials for the treatment of macular telangiectasia type II.
Felicitas Bucher, E. Aguilar, K. Marra, J. Rapp, Jakob Arnold, Sophia Diaz-Aguilar, C. Lange, H. Agostini, G. Schlunck, A. Stahl, M. Friedlander   +10 more
semanticscholar   +1 more source

PPARα-Dependent Effects of Palmitoylethanolamide Against Retinal Neovascularization and Fibrosis

Investigative Ophthalmology and Visual Science, 2020
Purpose Pathological neovascularization and fibrosis are common pathological changes of many retinal diseases, such as proliferative retinopathy (PR) and age-related macular degeneration (AMD).
Sihao Ye, Qian Chen, Nan Jiang, Xu Liang, Jingming Li, R. Zong, Caihong Huang, Y. Qiu, Jian-xing Ma, Zuguo Liu   +9 more
semanticscholar   +1 more source

Disruption of profilin1 function suppresses developmental and pathological retinal neovascularization

Journal of Biological Chemistry, 2020
Angiogenesis-mediated neovascularization in the eye is usually associated with visual complications. Pathological angiogenesis is particularly prominent in the retina in the settings of proliferative diabetic retinopathy, in which it can lead to ...
D. Gau, L. Vignaud, Abigail Allen, Zhijian Guo, J. Sahel, David N. Boone, D. Koes, X. Guillonneau, P. Roy   +8 more
semanticscholar   +1 more source

Concurrent management of myopic choroidal neovascularization and rhegmatogenous retinal detachment with intravitreal antivascular endothelial growth factor during primary retinal detachment repair

Indian Journal of Ophthalmology, 2018
We report concurrent management of rhegmatogenous retinal detachment and myopic choroidal neovascularization in the left eye of a 24-year-old female who presented with sudden dimness of vision due to retinal detachment and choroidal neovascularization ...
Kumar Saurabh, Rupak Roy, Nicey Roy Thomas, Maitreyi Chowdhury   +3 more
doaj   +1 more source

Mechanism of piR-1245/PIWI-like protein-2 regulating Janus kinase-2/signal transducer and activator of transcription-3/vascular endothelial growth factor signaling pathway in retinal neovascularization

Neural Regeneration Research, 2023
Inhibiting retinal neovascularization is the optimal strategy for the treatment of retina-related diseases, but there is currently no effective treatment for retinal neovascularization.
Yong Yu, Li-Kun Xia, Yu Di, Qing-Zhu Nie, Xiao-Long Chen   +4 more
doaj   +1 more source

Metformin inhibits pathological retinal neovascularization but promotes retinal fibrosis in experimental neovascular age-related macular degeneration. [PDF]

Front Pharmacol
PurposeThis study aims to investigate the effects and mechanism of action of metformin on retinal neovascularization and fibrosis in a mouse model of neovascular age-related macular degeneration (nAMD).MethodsVery low-density lipoprotein receptor ...
Wang X, Liang X, Huang S, Wei M, Xu Y, Chen X, Miao Y, Zong R, Lin X, Li S, Liu Z, Chen Q.   +11 more
europepmc   +2 more sources

Bim expression in endothelial cells and pericytes is essential for regression of the fetal ocular vasculature. [PDF]

PLoS ONE, 2017
Apoptosis plays a central role in developmental and pathological angiogenesis and vessel regression. Bim is a pro-apoptotic Bcl-2 family member that plays a prominent role in both developmental and pathological ocular vessel regression, and ...
Shoujian Wang, Ismail S Zaitoun, Ryan P Johnson, Nasim Jamali, Zafer Gurel, Catherine M Wintheiser, Andreas Strasser, Volkhard Lindner, Nader Sheibani, Christine M Sorenson   +9 more
doaj   +1 more source