Results 31 to 40 of about 385,405 (300)

Suppression of retinal neovascularization in vivo by inhibition of vascular endothelial growth factor (VEGF) using soluble VEGF-receptor chimeric proteins.

Proceedings of the National Academy of Sciences of the United States of America, 1995
Lloyd Paul Aiello, Eric A. Pierce, E D Foley, Hitoshi Takagi, Hui Chen, L Riddle, Napoleone Ferrara, George L. King, Lois E. H. Smith   +8 more
openalex   +3 more sources

YY1 lactylation in microglia promotes angiogenesis through transcription activation-mediated upregulation of FGF2

Genome Biology, 2023
Background Ocular neovascularization is a leading cause of blindness. Retinal microglia have been implicated in hypoxia-induced angiogenesis and vasculopathy, but the underlying mechanisms are not entirely clear.
Xiaotang Wang, Wei Fan, Na Li, Yan Ma, Mudi Yao, Guoqing Wang, Siyuan He, Wanqian Li, Jun Tan, Qi Lu, Shengping Hou   +10 more
doaj   +1 more source

LncRNA DANCR Activates p38/mTOR-Mediated Autophagy via ANXA2 to Exacerbate Oxygen-Induced Retinal Neovascularization in Mice. [PDF]

FASEB J
This study reveals that the long non‐coding RNA DANCR drives pathological retinal neovascularization in oxygen‐induced retinopathy via an ANXA2‐dependent p38/MAPK/mTOR autophagy pathway. In hypoxic endothelial cells and a murine OIR model, DANCR promotes angiogenesis.
Wang Y, Bai J, Zhao S.
europepmc   +2 more sources

Downregulation of PIK3IP1 in retinal microglia promotes retinal pathological neovascularization via PI3K-AKT pathway activation

Scientific Reports, 2023
Retinal pathological neovascularization involves endothelial cells, pericytes, photoreceptor cells, ganglion cells, and glial cells, whose roles remain unclear.
Lushu Chen, Yuan Cao, Yaming Shen, Huan Li, Rong Ye, Jin Yao   +5 more
doaj   +1 more source

Deletion of LRP5 in VLDLR knockout mice inhibits retinal neovascularization. [PDF]

PLoS ONE, 2013
The development and maintenance of retinal vasculature require a precise balance between pro-angiogenic and anti-angiogenic factors. However, mechanisms underlying normal homeostasis of retinal vasculature and pathological changes of disrupted retinal ...
Chun-hong Xia, Eric Lu, Jing Zeng, Xiaohua Gong   +3 more
doaj   +1 more source

Inhibiting NF-κB Signaling Activation Reduces Retinal Neovascularization by Promoting a Polarization Shift in Macrophages

Investigative Ophthalmology and Visual Science, 2020
Purpose Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) signaling is involved in regulating tumor angiogenesis and metastasis; however, the exact mechanism of action in retinal neovascularization (RNV) remains unclear.
Ailing Sui, Xiuping Chen, A. Demetriades, Jikui Shen, Yujuan Cai, Yiyun Yao, Yixuan Yao, Yanji Zhu, Xi Shen, B. Xie   +9 more
semanticscholar   +1 more source

PPARα-Dependent Effects of Palmitoylethanolamide Against Retinal Neovascularization and Fibrosis

Investigative Ophthalmology and Visual Science, 2020
Purpose Pathological neovascularization and fibrosis are common pathological changes of many retinal diseases, such as proliferative retinopathy (PR) and age-related macular degeneration (AMD).
Sihao Ye, Qian Chen, Nan Jiang, Xu Liang, Jingming Li, R. Zong, Caihong Huang, Y. Qiu, Jian-xing Ma, Zuguo Liu   +9 more
semanticscholar   +1 more source

CNTF Prevents Development of Outer Retinal Neovascularization Through Upregulation of CxCl10

Investigative Ophthalmology and Visual Science, 2020
Purpose Ciliary neurotrophic factor (CNTF) is a well-characterized neurotrophic factor currently in clinical trials for the treatment of macular telangiectasia type II.
Felicitas Bucher, E. Aguilar, K. Marra, J. Rapp, Jakob Arnold, Sophia Diaz-Aguilar, C. Lange, H. Agostini, G. Schlunck, A. Stahl, M. Friedlander   +10 more
semanticscholar   +1 more source

Cyclic AMP Response Element Binding Protein Mediates Pathological Retinal Neovascularization via Modulating DLL4-NOTCH1 Signaling

EBioMedicine, 2015
Retinal neovascularization is the most common cause of moderate to severe vision loss in all age groups. Despite the use of anti-VEGFA therapies, this complication continues to cause blindness, suggesting a role for additional molecules in retinal ...
Nikhlesh K. Singh, Sivareddy Kotla, Raj Kumar, Gadiparthi N. Rao   +3 more
doaj   +1 more source

Disruption of profilin1 function suppresses developmental and pathological retinal neovascularization

Journal of Biological Chemistry, 2020
Angiogenesis-mediated neovascularization in the eye is usually associated with visual complications. Pathological angiogenesis is particularly prominent in the retina in the settings of proliferative diabetic retinopathy, in which it can lead to ...
D. Gau, L. Vignaud, Abigail Allen, Zhijian Guo, J. Sahel, David N. Boone, D. Koes, X. Guillonneau, P. Roy   +8 more
semanticscholar   +1 more source