Results 31 to 40 of about 402,915 (338)

YY1 lactylation in microglia promotes angiogenesis through transcription activation-mediated upregulation of FGF2

Genome Biology, 2023
Background Ocular neovascularization is a leading cause of blindness. Retinal microglia have been implicated in hypoxia-induced angiogenesis and vasculopathy, but the underlying mechanisms are not entirely clear.
Xiaotang Wang, Wei Fan, Na Li, Yan Ma, Mudi Yao, Guoqing Wang, Siyuan He, Wanqian Li, Jun Tan, Qi Lu, Shengping Hou   +10 more
doaj   +1 more source

Downregulation of PIK3IP1 in retinal microglia promotes retinal pathological neovascularization via PI3K-AKT pathway activation

Scientific Reports, 2023
Retinal pathological neovascularization involves endothelial cells, pericytes, photoreceptor cells, ganglion cells, and glial cells, whose roles remain unclear.
Lushu Chen, Yuan Cao, Yaming Shen, Huan Li, Rong Ye, Jin Yao   +5 more
doaj   +1 more source

Deletion of LRP5 in VLDLR knockout mice inhibits retinal neovascularization. [PDF]

PLoS ONE, 2013
The development and maintenance of retinal vasculature require a precise balance between pro-angiogenic and anti-angiogenic factors. However, mechanisms underlying normal homeostasis of retinal vasculature and pathological changes of disrupted retinal ...
Chun-hong Xia, Eric Lu, Jing Zeng, Xiaohua Gong   +3 more
doaj   +1 more source

Mass spectrometry in ocular drug research

Mass Spectrometry Reviews, EarlyView., 2023
Abstract Mass spectrometry (MS) has been proven as an excellent tool in ocular drug research allowing analyzes from small samples and low concentrations. This review begins with a short introduction to eye physiology and ocular pharmacokinetics and the relevance of advancing ophthalmic treatments.
Eva M. del Amo, Kati‐Sisko Vellonen, Arto Urtti, Tetsuya Terasaki, Anam Hammid, Paavo Honkakoski, Seppo Auriola   +6 more
wiley   +1 more source

An allosteric peptide inhibitor of HIF-1α regulates hypoxia-induced retinal neovascularization

Proceedings of the National Academy of Sciences of the United States of America, 2020
Significance Retinal ischemia causes hypoxia-induced neovascularization that stimulates production of proangiogenic cytokines such as VEGF by the hypoxia-inducible transcription factors HIF-1 and HIF-2.
Ayumi Usui‐Ouchi, E. Aguilar, Salome Murinello, M. Prins, M. Gantner, P. Wright, R. Berlow, M. Friedlander   +7 more
semanticscholar   +1 more source

VEGF(164)-mediated inflammation is required for pathological, but not physiological, ischemia-induced retinal neovascularization [PDF]

, 2003
Hypoxia-induced VEGF governs both physiological retinal vascular development and pathological retinal neovascularization. In the current paper, the mechanisms of physiological and pathological neovascularization are compared and contrasted.
Adamis, AP, Amano, S, Ambati, J, D'Amore, PA, Gragoudas, ES, Hida, T, Ishida, S, Kaji, Y, Miller, JW, Ng, YS, Oguchi, Y, Ogura, Y, Shima, DT, Usui, T, Yamashiro, K   +14 more
core   +1 more source

Inhibiting NF-κB Signaling Activation Reduces Retinal Neovascularization by Promoting a Polarization Shift in Macrophages

Investigative Ophthalmology and Visual Science, 2020
Purpose Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) signaling is involved in regulating tumor angiogenesis and metastasis; however, the exact mechanism of action in retinal neovascularization (RNV) remains unclear.
Ailing Sui, Xiuping Chen, A. Demetriades, Jikui Shen, Yujuan Cai, Yiyun Yao, Yixuan Yao, Yanji Zhu, Xi Shen, B. Xie   +9 more
semanticscholar   +1 more source

MFGE8 does not influence chorio-retinal homeostasis or choroidal neovascularization in vivo [PDF]

, 2012
Purpose: Milk fat globule-epidermal growth factor-factor VIII (MFGE8) is necessary for diurnal outer segment phagocytosis and promotes VEGF-dependent neovascularization.
A Swaroop, AC Bird, Alfred Lewin, Bertrand Calippe, BL Burgess, C Combadiere, CA Augood, Christophe Combadière, Clotilde Théry, CY Hu, DA Tregouet, David-Alexandre Tregouet, DS Friedman, E Nandrot, EF Nandrot, EF Nandrot, Florian Sennlaub, Francine Behar-Cohen, G Sugano, H Baatz, H Kamizuru, Holger Baatz, JD Stubbs, JS Silvestre, K Atabai, K Oshima, Lucie Poupel, M Houssier, M Jinushi, M Paques, N Kwak, Nicole Keller, PD Sasieni, PJ Rosenfeld, PM D'Cruz, R Hanayama, R Hanayama, R Klein, R Klein, RB Edwards, RL Ceriani, RW Young, Salomon-Yves Cohen, SC Finnemann, Serge Camelo, SH Sarks, Sophie Krumeich, Sophie Lavalette, T Vinding, William Raoul, WR Green, X Ding, Xavier Guillonneau   +52 more
core   +7 more sources

Optical Coherence Tomographic Angiography Imaging in Age-Related Macular Degeneration. [PDF]

, 2017
Optical coherence tomographic angiography (OCTA) is emerging as a rapid, noninvasive imaging modality that can provide detailed structural and flow information on retinal and choroidal vasculature.
Desai, Ria, Fawzi, Amani, Gill, Manjot, Ma, Jeffrey, Nesper, Peter, Skondra, Dimitra   +5 more
core   +3 more sources

PPARα-Dependent Effects of Palmitoylethanolamide Against Retinal Neovascularization and Fibrosis

Investigative Ophthalmology and Visual Science, 2020
Purpose Pathological neovascularization and fibrosis are common pathological changes of many retinal diseases, such as proliferative retinopathy (PR) and age-related macular degeneration (AMD).
Sihao Ye, Qian Chen, Nan Jiang, Xu Liang, Jingming Li, R. Zong, Caihong Huang, Y. Qiu, Jian-xing Ma, Zuguo Liu   +9 more
semanticscholar   +1 more source