Results 41 to 50 of about 385,405 (300)

MicroRNA-409-5p promotes retinal neovascularization in diabetic retinopathy

Cell Cycle, 2020
Background: Retinal neovascularization, which is characterized by the increased proliferation, migration, and tube formation of retinal microvascular endothelial cells (RMECs), contributes to the progression of diabetic retinopathy (DR).
Ying Wang, Wenwen Lin, Jianghua Ju
semanticscholar   +1 more source

Concurrent management of myopic choroidal neovascularization and rhegmatogenous retinal detachment with intravitreal antivascular endothelial growth factor during primary retinal detachment repair

Indian Journal of Ophthalmology, 2018
We report concurrent management of rhegmatogenous retinal detachment and myopic choroidal neovascularization in the left eye of a 24-year-old female who presented with sudden dimness of vision due to retinal detachment and choroidal neovascularization ...
Kumar Saurabh, Rupak Roy, Nicey Roy Thomas, Maitreyi Chowdhury   +3 more
doaj   +1 more source

P2X7 Receptor Antagonist Attenuates Retinal Inflammation and Neovascularization Induced by Oxidized Low-Density Lipoprotein

Oxidative Medicine and Cellular Longevity, 2021
Age-related macular degeneration (AMD) is a common and severe blinding disease among people worldwide. Retinal inflammation and neovascularization are two fundamental pathological processes in AMD.
Mingzhu Yang, Ruiqi Qiu, Weiping Wang, Jingyang Liu, Xiuxiu Jin, Ya Li, Lei Li, B. Lei   +7 more
semanticscholar   +1 more source

Bim expression in endothelial cells and pericytes is essential for regression of the fetal ocular vasculature. [PDF]

PLoS ONE, 2017
Apoptosis plays a central role in developmental and pathological angiogenesis and vessel regression. Bim is a pro-apoptotic Bcl-2 family member that plays a prominent role in both developmental and pathological ocular vessel regression, and ...
Shoujian Wang, Ismail S Zaitoun, Ryan P Johnson, Nasim Jamali, Zafer Gurel, Catherine M Wintheiser, Andreas Strasser, Volkhard Lindner, Nader Sheibani, Christine M Sorenson   +9 more
doaj   +1 more source

Mechanism of piR-1245/PIWI-like protein-2 regulating Janus kinase-2/signal transducer and activator of transcription-3/vascular endothelial growth factor signaling pathway in retinal neovascularization

Neural Regeneration Research, 2023
Inhibiting retinal neovascularization is the optimal strategy for the treatment of retina-related diseases, but there is currently no effective treatment for retinal neovascularization.
Yong Yu, Li-Kun Xia, Yu Di, Qing-Zhu Nie, Xiao-Long Chen   +4 more
doaj   +1 more source

PKCθ-JunB axis via upregulation of VEGFR3 expression mediates hypoxia-induced pathological retinal neovascularization

Cell Death and Disease, 2020
Pathological retinal neovascularization is the most common cause of vision loss. PKCθ has been shown to play a role in type 2 diabetes, which is linked to retinal neovascularization.
Raj Kumar, Arul M. Mani, Nikhlesh K. Singh, G. Rao   +3 more
semanticscholar   +1 more source

Vascular cell-adhesion molecule 1 (VCAM-1) regulates JunB-mediated IL-8/CXCL1 expression and pathological neovascularization

Communications Biology, 2023
Vascular adhesion molecules play an important role in various immunological disorders, particularly in cancers. However, little is known regarding the role of these adhesion molecules in proliferative retinopathies.
Geetika Kaur, Deepti Sharma, Shivantika Bisen, Chandra Sekhar Mukhopadhyay, Katherine Gurdziel, Nikhlesh K. Singh   +5 more
doaj   +1 more source

Peripheral Retinal Neovascularization with Vitreous Hemorrhage in HIV Retinopathy

Case Reports in Ophthalmology, 2017
We report a case of peripheral retinal neovascularization and vitreous hemorrhage in the setting of HIV retinopathy that can serve to extend the clinical spectrum of this condition.
Kim Jiramongkolchai, Tin Yan Alvin Liu, J. Fernando Arevalo   +2 more
doaj   +1 more source

A new role for cofilin in retinal neovascularization

Journal of Cell Science, 2016
Raj Kumar, Jagadeesh Janjanam, Nikhlesh K. Singh, Gadiparthi N. Rao   +3 more
openalex   +2 more sources

Endothelium Expression of Bcl-2 Is Essential for Normal and Pathological Ocular Vascularization.

PLoS ONE, 2015
Bcl-2 is an anti-apoptotic protein with important roles in vascular homeostasis and angiogenesis. Mice globally lacking Bcl-2 (Bcl-2 -/-) are small in stature and succumb to renal failure shortly after weaning as a result of renal hypoplasia/cystic ...
Ismail S Zaitoun, Ryan P Johnson, Nasim Jamali, Reem Almomani, Shoujian Wang, Nader Sheibani, Christine M Sorenson   +6 more
doaj   +1 more source