Results 81 to 90 of about 371,429 (272)

FGF21 Administration Suppresses Retinal and Choroidal Neovascularization in Mice

Cell Reports, 2017
Pathological neovascularization, a leading cause of blindness, is seen in retinopathy of prematurity, diabetic retinopathy, and age-related macular degeneration.
Zhongjie Fu, Yan Gong, Raffael Liegl, Zhongxiao Wang, Chi-Hsiu Liu, Steven S. Meng, Samuel B. Burnim, Nicholas J. Saba, Thomas W. Fredrick, Peyton C. Morss, Ann Hellstrom, Saswata Talukdar, Lois E.H. Smith   +12 more
doaj   +1 more source

Anemia and retinopathy of prematurity: A narrative review

Pediatric Investigation, EarlyView.
Anemia in infants who are at greatest risk of developing severe retinopathy of prematurity is almost universal. There is plausible evidence in the literature correlating anemia with severe ROP. However, the relationship is complex, and further study is needed to better understand the potential molecular mechanisms for anemia‐associated ROP.
Minali Prasad, David Dombrovsky, Stephen P. Christiansen, Ellen C. Ingolfsland   +3 more
wiley   +1 more source

Receptor-Interacting Protein Kinase-3 Expression Impacts Ocular Vascular Development and Pathological Neovascularization

Cells
Functional cell death pathways are essential for normal ocular vascular development and tissue homeostasis. As our understanding of necrosis-based cell death pathways has expanded, the inclusion of regulated forms, including necroptosis, ferroptosis, and
Yong-Seok Song, Shoujian Wang, SunYoung Park, Barbara Hanna, Kelsey J. Johnson, Soesiawati R. Darjatmoko, Mohammad Ali Saghiri, Ali Mohammad Saghiri, Bo Liu, Christine M. Sorenson, Nader Sheibani   +10 more
doaj   +1 more source

NADPH Oxidase 4-Derived H2O2 Promotes Aberrant Retinal Neovascularization via Activation of VEGF Receptor 2 Pathway in Oxygen-Induced Retinopathy

Journal of Diabetes Research, 2015
NADPH oxidase 4 (Nox4) is a major isoform of NADPH oxidase in retinal endothelial cells. Our previous study suggests that upregulation of Nox4 in retinal endothelial cells contributes to retinal vascular leakage in diabetes.
Jingming Li, J. Wang, Sarah X. Zhang
semanticscholar   +1 more source

The Impact of Allogeneic Hematopoietic Stem Cell Transplantation on Sickle Cell Retinopathy and Maculopathy: A Prospective, Observational Study

American Journal of Hematology, EarlyView.
Rajani P. Brandsen, Elisabeth Dovern, Bart J. Biemond, Roselie M. H. Diederen, Erfan Nur   +4 more
wiley   +1 more source

Ocular involvement in newly diagnosed pediatric leukemia: A systematic review and meta‐analysis

Pediatric Investigation, EarlyView.
The global prevalence of ocular involvement in pediatric leukemia is estimated to be 20.32%, which is more common than previously recognized. Given the high rate of asymptomatic involvement, screening for all newly diagnosed leukemia patients is recommended.
Kristina Nazzicone, Rachel Kim, Alexa Fine, Aidan Pucchio, Laura Wheaton, Christine Law   +5 more
wiley   +1 more source

Synthesis and Biological Evaluation of Novel Homoisoflavonoids for Retinal Neovascularization.

Journal of Medicinal Chemistry, 2015
Eye diseases characterized by excessive angiogenesis such as wet age-related macular degeneration, proliferative diabetic retinopathy, and retinopathy of prematurity are major causes of blindness.
Halesha D. Basavarajappa, Bit Lee, Hyungjun Lee, Rania S. Sulaiman, Hongchan An, Carlos Magaña, Mehdi Shadmand, Alexandra Vayl, Gangaraju Rajashekhar, Eun-Yeong Kim, Y. Suh, Kiho Lee, Seung‐Yong Seo, T. Corson   +13 more
semanticscholar   +1 more source

Application of artificial intelligence in myopia prevention and control

Pediatric Investigation, EarlyView.
Current applications of artificial intelligence (AI) in the field of myopia prevention and control were comprehensively reviewed. Challenges, current development status, and future directions of AI have also been discussed, holding great significance for the further application of AI in myopia management.
Nan Liu, Li Li, Jifeng Yu
wiley   +1 more source

Hypoxia-Induced Retinal Neovascularization in Zebrafish Embryos: A Potential Model of Retinopathy of Prematurity

PLoS ONE, 2015
Retinopathy of prematurity, formerly known as a retrolental fibroplasia, is a leading cause of infantile blindness worldwide. Retinopathy of prematurity is caused by the failure of central retinal vessels to reach the retinal periphery, creating a ...
Yu-Ching Wu, Chao-Yuan Chang, Alex P. Kao, Brian Hsi, Shwu‐Huey Lee, Yau-Hung Chen, I. Wang   +6 more
semanticscholar   +1 more source

Experimental and Computational Insights into the Structural Dynamics of the Fc Fragment of IgG1 Subtype from Biosimilar VEGF‐Trap

Small Structures, EarlyView.
The constant fragment (Fc) of the immunoglobulin G1 (IgG1) subtype is a widely used scaffold for designing advanced therapeutics. Herein, together with the integration of experimental and computational techniques, this study reveals the structural dynamics of the N‐glycan‐bound Fc fragment of IgG1 from VEGF‐Trap, providing a new insight into enhancing ...
Ebru Destan, Engin Turkut, Alper Aldeniz, Jungmin Kang, Takehiko Tosha, Makina Yabashi, Baris Yilmaz, Ahmet Can Timucin, Hiroaki Matsuura, Yoshiaki Kawano, Irfan Cinkaya, Hasan DeMirci   +11 more
wiley   +1 more source