20th Anniversary of human‐induced pluripotent stem cells and the role of microscopy
Abstract It has been 20 years since the pioneering work of Shinya Yamanaka and Kazutoshi Takahashi at Kyoto University led to the first successful generation of induced pluripotent stem cells (iPSCs) from mouse embryonic and adult fibroblast cells. iPSCs have the capacity to differentiate into any type of cell in the human body, and as such, they have ...
Philomena Hallford +3 more
wiley +1 more source
Induction of Oxidative Stress on Retinal Pigment Epithelial Cells Triggered a Proangiogenic Environment. [PDF]
Abdouh M +3 more
europepmc +1 more source
ABSTRACT Despite all efforts, obesity remains a major health concern worldwide, with continuously increasing rates, affecting approx. 14% of the total world population, being as high as 43% in some countries. As obesity is related to numerous comorbidities, including type 2 diabetes, cardiovascular diseases, and some types of cancer, the consequences ...
Farhad Vahid +22 more
wiley +1 more source
Soft matrix promotes ciliogenesis in human retinal pigment epithelial cells. [PDF]
Zahra R +6 more
europepmc +1 more source
Oral Lichenoid Lesions in Patients With Dyskeratosis Congenita: A Retrospective Case Series
ABSTRACT Background Dyskeratosis congenita (DKC) is a rare inherited multisystem disorder primarily affecting the mucocutaneous and hematopoietic systems. Classically, it presents with the ectodermal triad of reticulate skin pigmentation, nail dystrophy, and oral leukoplakia.
Yehuda Zadik +9 more
wiley +1 more source
Physiological Hypoxia and Pharmacological HIF Stabilization Induce Distinct but Overlapping Responses in Retinal Pigment Epithelial Cells. [PDF]
Gáll T +4 more
europepmc +1 more source
Techniques for subretinal injections in animals
Abstract Subretinal injections are not commonly performed during clinical treatment of animals but are frequently used in laboratory animal models to assess therapeutic efficacy and safety of gene and cell therapy products. Veterinary ophthalmologists are often employed to perform the injections in the laboratory animal setting, due to knowledge of ...
Ryan F. Boyd, Simon M. Petersen‐Jones
wiley +1 more source
Mapping the Hypoxic Fitness Landscape of Retinal Pigment Epithelial Cells. [PDF]
Calbay O +8 more
europepmc +1 more source
Abstract Corneal reconstruction is a key part of veterinary ophthalmic practice and numerous reconstructive techniques have been described for use in small animals in the peer‐reviewed veterinary literature written in English. Despite the evidence accrued over the last six decades in over 40 clinical articles and numerous other publications on ocular ...
Rick F. Sanchez +2 more
wiley +1 more source
Resveratrol mitigates hypoxia-induced mitochondrial oxidative damage and apoptosis <i>via</i> inhibition of TRPA1 channel in retinal pigment epithelial cells. [PDF]
Argun M, Nazıroğlu M.
europepmc +1 more source

