Results 81 to 90 of about 34,005 (206)

Lycium barbarum polysaccharides protected human retinal pigment epithelial cells against oxidative stress-induced apoptosis

International Journal of Ophthalmology, 2015
AIM: To investigate the protective effect and its mechanism of lycium barbarum polysaccharides (LBP) against oxidative stress-induced apoptosis in human retinal pigment epithelial cells.
Lian Liu, Wei Lao, Qing-Shan Ji, Zhi-Hao Yang, Wei Lao, Jing-Xiang Zhong   +5 more
doaj   +1 more source

Selective non-steroidal glucocorticoid receptor agonists attenuate inflammation but do not impair intestinal epithelial cell restitution in vitro

, 2012
Introduction: Despite the excellent anti-inflammatory and immunosuppressive action of glucocorticoids (GCs), their use for the treatment of inflammatory bowel disease (IBD) still carries significant risks in terms of frequently occurring severe side ...
Kerstin C Reuter, Jürgen Stein, Axel U Dignass, Stefan M Loitsch, Dieter Steinhilber (182458), Reuter, Kerstin C., Dignaß, Axel Uwe, Kerstin C. Reuter (186426), Dieter Steinhilber, Stefan M. Loitsch (186433), Loitsch, Stefan Marcel, Stein, Jürgen, Axel U. Dignass (186440), Steinhilber, Dieter, Jürgen Stein (186447)   +14 more
core   +1 more source

Brief research report: Transcriptional blockade of angiotensin converting enzyme 2 modelled in human retinal pigment epithelial cells

Frontiers in Drug Discovery
As a key host protein involved in cellular infection by the severe acute respiratory syndrome coronavirus (SARS-CoV-2), angiotensin converting enzyme (ACE)2 is an ideal target for antiviral drugs.
Liam M. Ashander, Amanda L. Lumsden, Yuefang Ma, Alwin Chun Rong Tan, Binoy Appukuttan, Santhosh Daniel, Santhosh Daniel, Michael Z. Michael, Michael Z. Michael, Justine R. Smith, Justine R. Smith   +10 more
doaj   +1 more source

Effect of EGb761 on light-damaged retinal pigment epithelial cells

International Journal of Ophthalmology, 2014
AIM:To investigate the protective mechanism of Gingko Biloba extract (EGb761) on the ability of retinal pigment epithelial (RPE) cells to resist light-induced damage in a comparative proteomics study.METHODS:Human RPE cells (ARPE-19) were randomly ...
Yun-Yun Zhou, Chang-Zheng Chen, Yu Su, Lu Li, Zuo-Hui-Zi Yi, Hang Qi, Ming Weng, Yi-Qiao Xing   +7 more
doaj   +1 more source

Cytotoxic Effect of Spermine on Retinal Pigment Epithelial Cells

Investigative Opthalmology & Visual Science, 2007
A prior study showed inactivation of ornithine-delta-aminotransferase (OAT)-deficient human retinal pigment epithelial (RPE) cells by a specific irreversible inhibitor (5-fluoromethylornithine; 5-FMO) leading to cell death, in an in vitro model of gyrate atrophy (GA) of the choroid and retina.
Shiho, Kaneko, Mami, Ueda-Yamada, Akira, Ando, Shinji, Matsumura, Emiko, Okuda-Ashitaka, Miyo, Matsumura, Masanobu, Uyama, Seiji, Ito   +7 more
openaire   +2 more sources

Photocytotoxicity of lipofuscin in human retinal pigment epithelial cells

Free Radical Biology and Medicine, 2001
Lipofuscin accumulates with age in a variety of highly metabolically active cells, including the retinal pigment epithelium (RPE) of the eye, where its photoreactivity has the potential for cellular damage. The aim of this study was to assess the phototoxic potential of lipofuscin in the retina.
Davies, Sallyanne, Elliott, Michael H., Floor, Eric, Truscott, T. George, Zaręba, Mariusz, Sarna, Tadeusz, Shamsi, Farrukh A., Boulton, Michael E.   +7 more
openaire   +3 more sources

Cyclic GMP in the pig vitreous and retina after experimental retinal detachment

, 2008
Purpose: Earlier studies have revealed a decreased level of cGMP in vitreous fluid obtained from patients with a retinal detachment. To further investigate this phenomenon, we developed an experimental retinal detachment model in pigs.
Heij, E.C., La, La Heij, Ellen C, Diederen, R., Diederen, Roselie M H, Lemmens, Marijke A M, de Vente, Jan, De Vente, J., La Heij, E.C., Lemmens, M.A.M., Kijlstra, Aize, Vente, J., De, Hendrikse, F., Hendrikse, Fred, Kijlstra, A.   +13 more
core  

Effects of Phenothiazines on Cultured Retinal Pigment Epithelial Cells

Ophthalmic Research, 2009
Phenothiazines (chlorpromazine, trifluoperazine, prochlorperazine, and fluphenazine) showed dose-dependent inhibition of phagocytosis of latex particles by cultured chick retinal pigment epithelial cells at concentrations of 10-5–10-14 mol/1. Calmodulin antagonists (W-5, W-7, W-12, and W-13) showed similar effects as phenothiazines at concentrations of
M, Matsumura, R, Yamakawa, H, Shirakawa, N, Ogino   +3 more
openaire   +2 more sources

Identification of hydroxyapatite spherules provides new insight into subretinal pigment epithelial deposit formation in the aging eye.

, 2015
Accumulation of protein- and lipid-containing deposits external to the retinal pigment epithelium (RPE) is common in the aging eye, and has long been viewed as the hallmark of age-related macular degeneration (AMD).
Flinn, JM, Lanzirotti, A, McPhail, DS, Fearn, S, Ueffing, M, Boldt, K, Ratu, SG, Lengyel, I, Thompson, RB, Kortvely, E, Pauleikhoff, L, Bird, AC, Reffatto, V, Bundy, JG, Jones, EA   +14 more
core  

Effects of Light-emitting Diode Radiations on Human Retinal Pigment Epithelial Cells In Vitro

, 2012
Human visual system is exposed to high levels of natural and artificial lights of different spectra and intensities along lifetime. Light-emitting diodes (LEDs) are the basic lighting components in screens of PCs, phones and TV sets; hence it is so ...
Cristina Bonnin-arias, Sánchez Ramos, Celia, Daniel Vázquez, Celia Sánchez-ramos, Vázquez Molini, Daniel, Javier Muñoz De Luna, María Jesús Pérez-carrasco, Bonnin Arias, Cristina Natalia, Pérez Carrasco, María Jesús, Chamorro, Eva, Eva Chamorro, Muñoz de Luna, Javier   +11 more
core   +1 more source