Results 101 to 110 of about 91,639 (372)

NLRP3 Upregulation in Retinal Pigment Epithelium in Age-Related Macular Degeneration

International Journal of Molecular Sciences, 2016
Inflammation and oxidative stress are involved in age-related macular degeneration (AMD) and possibly associated with an activation of neuronal apoptosis inhibitor protein/class II transcription activator of the Major Histocompatibility Complex (MHC ...
Yujuan Wang, J. Hanus, M. Abu-Asab, D. Shen, Alexander Ogilvy, J. Ou, X. Chu, G. Shi, Wei Li, Shusheng Wang, C. Chan   +10 more
semanticscholar   +1 more source

Magnetic‐Guided Delivery of Antisense Oligonucleotides for Targeted Transduction in Multiple Retinal Explant and Organoid Models

Advanced Science, EarlyView.
Magnetic field‐guided MNP@ATR‐ASO nanocomplexes facilitate the targeted delivery of ASOs to ganglion cells or photoreceptors within retinal explants, thereby enhancing the efficacy of ASOs in correcting pre‐mRNA splicing abnormalities. Furthermore, the nanocomplexes improve ASO penetration and delivery in human retinal and inner ear organoid models ...
Xiuhong Ye, Sihui Chen, Wei Xiong, Fan Wang, Hon Fai Chan, Haocheng Lai, Xiangyu Guo, Tingting Yang, Shuhao Shen, Hang Chen, Wenxuan Wang, Guei‐Sheung Liu, Yonglong Guo, Jiansu Chen   +13 more
wiley   +1 more source

JAPANESE QUAIL (COTURNIX JAPONICA) AS A MODEL OF ACCELERATED AGING OF HUMAN RETINAL PROCESSES. REPORT 1. ASSESSMENT OF THE AGE RPE LIPOFUSCIN ACCUMULATION DEPENDING ON THE RETINAL AMOUNT OF OXYCAROTENOIDS

Офтальмохирургия, 2015
Purpose. Using the eyes of quails C. japonic as a model system to evaluate age-related accumulation of lipofuscin granules in the cells of the retinal pigment epithelium depending on the level of oxycarotenoids content in the retina and in the retinal ...
P. P. Zak, A. V. Zykova, N. N. Trofimova, M. A. Ostrovsky   +3 more
doaj  

Single-cell transcriptome of the mouse retinal pigment epithelium in response to a low-dose of doxorubicin

Communications Biology, 2022
Single cell transcriptomics pinpoints a cell subpopulation that could be involved in inducing cellular senescence of the retinal pigment epithelium, which in turn may construe retinal degenerative disease.
Hyungwoo Lee, Ho-Yeon Lee, Jae-Byoung Chae, Chul-Woo Park, Chaekyu Kim, Ja-Hyoung Ryu, Jiwon Jang, Namshin Kim, Hyewon Chung   +8 more
doaj   +1 more source

A new microscopy for imaging retinal cells [PDF]

arXiv, 2017
The evaluation and monitoring of cells health in the human retina is crucial and follow time course of retinal diseases, detect lesions before irreversible visual loss and to evaluate treatment effects. Towards this goal, a major challenge is to image and quantify retinal cells in human eyes in a non-invasive manner.
arxiv  

Non-contact, in-vivo, functional, and structural ophthalmic imaging using multimodal photoacoustic remote sensing (PARS) microscopy and optical coherence tomography (OCT) [PDF]

arXiv, 2021
Early diagnosis of ocular diseases improves the understanding of pathophysiology and helps with accurate monitoring and effective treatment. Advanced multimodal ocular imaging platforms play a crucial role in the visualization of the ocular components and provide clinicians with a valuable tool for evaluating different eye diseases. Here, for the first
arxiv  

Modulation of Immune Responses by Extracellular Vesicles From Retinal Pigment Epithelium

Investigative Ophthalmology and Visual Science, 2016
Purpose Extracellular vesicles (EV), such as exosomes, are important mediators of intercellular communication and have been implicated in modulation of the immune system.
J. Knickelbein, Baoying Liu, A. Arakelyan, S. Zicari, S. Hannes, Ping Chen, Zhiyu Li, J. Grivel, B. Chaigne-Delalande, H. Sen, L. Margolis, R. Nussenblatt   +11 more
semanticscholar   +1 more source

OcuPair, a Novel Photo‐crosslinkable PAMAM Dendrimer‐Hyaluronic Acid Hydrogel Bandage/Bioadhesive for Corneal Injuries and Temporary Corneal Repair

Advanced Science, EarlyView.
A schematic diagram showing the OcuPair adhesive hydrogel formulation loaded into the final delivery device and applied over the full‐thickness corneal wound in an in vivo rabbit model of corneal injury followed by in situ crosslinking to form a transparent hydrogel bandage sealing the wound.
Siva P. Kambhampati, Rishi Sharma, Hui Lin, Santiago Appiani, Jeffrey L. Cleland, Samuel C. Yiu, Rangaramanujam M. Kannan   +6 more
wiley   +1 more source

Japanese quail (Coturnix japonica) as a model of accelerated aging of human retinal processes. Report 1. Assessment of the age RPE lipofuscin accumulation depending on the retinal amount of oxycarotenoids

Офтальмохирургия, 2013
Purpose. Using the eyes of quails C. japonic as a model system to evaluate age-related accumulation of lipofuscin granules in the cells of the retinal pigment epithelium depending on the level of oxycarotenoids content in the retina and in the retinal ...
P.P. Zak, A.V. Zykova, N.N. Trofimova, M.A. Ostrovsky   +3 more
doaj  

Druse-Induced Morphology Evolution in Retinal Pigment Epithelium [PDF]

arXiv, 2016
The retinal pigment epithelium (RPE) is a key site of pathogenesis for many retina diseases. The formation of drusen in the retina is characteristic of retinal degeneration. We investigate morphological changes in the RPE in the presence of soft drusen using an integrated experimental and modeling approach. We collect RPE flat mount images from donated
arxiv