Results 121 to 130 of about 91,639 (372)

Microtubule motors transport phagosomes in the RPE, and lack of KLC1 leads to AMD-like pathogenesis. [PDF]

, 2015
The degradation of phagosomes, derived from the ingestion of photoreceptor outer segment (POS) disk membranes, is a major role of the retinal pigment epithelium (RPE). Here, POS phagosomes were observed to associate with myosin-7a, and then kinesin-1, as
Diemer, Tanja, Esteve-Rudd, Julian, Jiang, Mei, Lillo, Concepción, Lopes, Vanda S, Rump, Agrani, Williams, David S   +6 more
core   +1 more source

Sustained gene expression in the retina by improved episomal vectors [PDF]

, 2014
Gene and cellular therapies are nowadays part of therapeutic strategies for the treatment of diverse pathologies. The drawbacks associated with gene therapy-low levels of transgene expression, vector loss during mitosis, and gene silencing-need to be ...
Ana V. Oliveira, Conley S.M., Davis A.A., Gabriela A. Silva, Reinisalo M., Rudolf Haase, Sofia M. Calado, Susana Machado   +7 more
core   +1 more source

Costello Syndrome and Ophthalmologic Issues: Unveiling the Unseen

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Costello syndrome (CS) is an ultra‐rare condition belonging to the RASopathies, a group of disorders characterized by aberrant RAS/MAPK pathway signaling, which is involved in ocular development and in some eye pathologies. However, only a few studies assessing the ophthalmic features of individuals with CS are available.
Sofia Peschiaroli, Germana Viscogliosi, Annabella Salerni, Emanuele Crincoli, Roberta Mattei, Tommaso Verdolotti, Serafina Antonella Loprete, Valentina Trevisan, Giovanni Antonio Marrocco, Alessia Cherubino, Lucrezia Perri, Roberta Onesimo, Giuseppe Zampino, Chiara Leoni   +13 more
wiley   +1 more source

RETINAL PIGMENT EPITHELIUM CONDITION AFTER LASER AND ULTRASOUND PHACOFRAGMENTATION. ELECTRON MICROSCOPY IN EXPERIMENT. REPORT 1

Офтальмохирургия, 2015
Purpose. To perform a comparative evaluation of a macular retinal pigment epithelium condition after laser and ultrasound phacofragmentations in experiment.Material and method.
S. Y. Kopayev, V. G. Kopayeva, S. A. Borsenok, V. U. Alborova   +3 more
doaj  

Electro-oculography in bilateral optic neuropathy

BMC Research Notes, 2020
Objective Effect of bilateral, optic neuropathy on the function of retinal pigment epithelium has not been investigated extensively to date. This study aimed to determine the effect of bilateral, optic neuropathy on light peak:dark trough ratio, light ...
Padmini Dahanayake, Tharaka L. Dassanayake, Manoji Pathirage, Saman Senanayake, Mike Sedgwick, Vajira Weerasinghe   +5 more
doaj   +1 more source

Knowledge infused cascade convolutional neural network for segmenting retinal vessels in volumetric optical coherence tomography [PDF]

arXiv, 2019
We present a cascade deep neural network to segment retinal vessels in volumetric optical coherence tomography (OCT). Two types of knowledge are infused into the network for confining the searching regions. (1) Histology. The retinal vessels locate between the inner limiting membrane and the inner nuclear layer of human retina. (2) Imaging.
arxiv  

Appropriately differentiated ARPE-19 cells regain phenotype and gene expression profiles similar to those of native RPE cells. [PDF]

, 2017
PurposeThe RPE cell line ARPE-19 provides a dependable and widely used alternative to native RPE. However, replication of the native RPE phenotype becomes more difficult because these cells lose their specialized phenotype after multiple passages ...
Duncan, Todd, Jaworski, Cynthia, Kutty, R Krishnan, Lakkaraju, Aparna, Poliakov, Eugenia, Postnikova, Olga A, Redmond, T Michael, Samuel, William, Tan, Li Xuan   +8 more
core   +2 more sources

Preliminary study on electrophysiological changes after cellular autograft in age-related macular degeneration [PDF]

, 2014
Background: Evolving atrophic macular degeneration represents at least 80% of all macular degenerations and is currently without a standardized care. Autologous fat transplantation (AFT) efficacy was demonstrated by several studies, since these cells are
C., Limoli, M. U., Morales, Nebbioso, Marcella, P. G., Limoli, Vingolo, Enzo Maria   +4 more
core   +1 more source

The NLRP3 inflammasome pathway contributes to chronic inflammation in experimental autoimmune uveitis

Animal Models and Experimental Medicine, EarlyView.
The present study investigates the role of the NLRP3 inflammasome in the chronicity of ocular inflammation in uveitis using the experimental autoimmune uveitis (EAU) model. Whole eyes collected from EAU mice, 12 weeks post induction, were sectioned and subjected to immunohistochemistry. The confocal images from these sections were then assessed for the
Avik Shome, Ilva D. Rupenthal, Rachael L. Niederer, Odunayo O. Mugisho   +3 more
wiley   +1 more source

Identification of PLXDC1 and PLXDC2 as the transmembrane receptors for the multifunctional factor PEDF. [PDF]

, 2014
Pigment Epithelium Derived Factor (PEDF) is a secreted factor that has broad biological activities. It was first identified as a neurotrophic factor and later as the most potent natural antiangiogenic factor, a stem cell niche factor, and an inhibitor of
Al-Ubaidi, Muayyad, Cheng, Guo, Deng, Jun, Kassai, Miki, Kawaguchi, Riki, Sun, Hui, Ter-Stepanian, Mariam, Zhong, Ming   +7 more
core   +1 more source