Results 31 to 40 of about 91,639 (372)

Occlusion of retinal capillaries caused by glial cell proliferation in chronic ocular inflammation [PDF]

open access: yes, 2015
The inner blood-retinal barrier is a gliovascular unit in which glial cells surround capillary endothelial cells and regulate retinal capillaries by paracrine interactions.
Artico, Marco   +8 more
core   +2 more sources

Dissecting the transcriptome landscape of the human fetal neural retina and retinal pigment epithelium by single-cell RNA-seq analysis

open access: yesPLoS Biology, 2019
The developmental pathway of the neural retina (NR) and retinal pigment epithelium (RPE) has been revealed by extensive research in mice. However, the molecular mechanisms underlying the development of the human NR and RPE, as well as the interactions ...
Yuqiong Hu   +12 more
semanticscholar   +1 more source

Retinal regions shape human and murine Müller cell proteome profile and functionality

open access: yesGlia, Volume 71, Issue 2, Page 391-414, February 2023., 2023
Main Points We defined Müller cells heterogeneity in the macular and peripheral human retina. Signaling pathways shaping this glial heterogeneity include proteins important for interaction with vesicular secretion, extracellular matrix and cell adhesion.
Lew Kaplan   +15 more
wiley   +1 more source

Spectral Domain Optical Coherence Tomography in Simple Retina Pigment Epithelium Hamartoma

open access: yesTürk Oftalmoloji Dergisi, 2012
To report the spectral-domain optical coherence tomographic findings in a case of a simple hamartoma of the retinal pigment epithelium. A 55-year-old female patient with simple hamartoma of the retinal pigment epithelium was evaluated with ...
Melis Palamar Onay, Ayşe Yağcı
doaj   +1 more source

Associations with photoreceptor thickness measures in the UK Biobank. [PDF]

open access: yes, 2019
Spectral-domain OCT (SD-OCT) provides high resolution images enabling identification of individual retinal layers. We included 32,923 participants aged 40-69 years old from UK Biobank.
Aslam, Tariq   +77 more
core   +10 more sources

Expression of ABCA4 in the retinal pigment epithelium and its implications for Stargardt macular degeneration

open access: yesProceedings of the National Academy of Sciences of the United States of America, 2018
Significance Recessive Stargardt macular degeneration (STGD1) and a subset of cone–rod dystrophies are caused by mutations in the Abca4 gene. The ABCA4 protein is a flippase in photoreceptor cells that helps eliminate retinaldehyde, a toxic photoproduct ...
T. Lenis   +14 more
semanticscholar   +1 more source

Functional characterization of a novel TP53RK mutation identified in a family with Galloway–Mowat syndrome

open access: yesHuman Mutation, Volume 43, Issue 12, Page 1866-1871, December 2022., 2022
Abstract Galloway–Mowat syndrome (GAMOS) is a very rare condition characterized by early‐onset nephrotic syndrome and microcephaly with variable neurologic features. While considerable genetic heterogeneity of GAMOS has been identified, the majority of cases are caused by pathogenic variants in genes encoding the four components of the Kinase ...
Ernestine Treimer   +8 more
wiley   +1 more source

Spectral optical coherence tomography findings in an elderly patient with syphilitic bilateral chronic panuveitis

open access: yesAmerican Journal of Ophthalmology Case Reports, 2018
Purpose: To report the spectral domain optical coherence tomography (SD-OCT) features of a focal retinitis in an elderly male patient with bilateral syphilitic panuveitis.
Ariel Schlaen   +3 more
doaj   +1 more source

Common clinical features of unilateral retinal pigment epithelium dysgenesis and combined hamartoma of the retina and retinal pigment epithelium

open access: yesBMC Ophthalmology, 2022
Background Herein, we report two cases of unilateral retinal pigment epithelium dysgenesis (URPED) in Chinese patients and explore the relationship between URPED and combined hamartoma of the retina and retinal pigment epithelium (CHRRPE).
Zhe Zhu   +5 more
doaj   +1 more source

Evaluation of an Intravitreal Rho-Associated Kinase Inhibitor Depot Formulation in a Rat Model of Diabetic Retinopathy

open access: yesPharmaceutics, 2021
Rho-associated kinase (ROCK) activation was shown to contribute to microvascular closure, retinal hypoxia, and to retinal pigment epithelium (RPE) barrier disruption in a rat model of diabetic retinopathy.
Cecile Lebon   +10 more
doaj   +1 more source

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