Results 111 to 120 of about 48,539 (287)

Notch signaling represses cone photoreceptor formation through the regulation of retinal progenitor cell states [PDF]

, 2020
Xueqing Chen, Mark M. Emerson
openalex   +1 more source

Transthyretin levels in the vitreous correlate with change in visual acuity after vitrectomy [PDF]

, 2009
Background/aim: Little is known about biochemical markers related to change in visual acuity after vitrectomy. The potential use of transthyretin (TTR), a carrier of the retinol/retinol-binding protein, as a biochemical marker protein, was investigated ...
De Letter, Els, Delanghe, Joris, Delanghe, S, Derycke, Lara, Geers, I, Van Aken, Elisabeth, van Enschot, T, Veckeneer, M   +7 more
core   +3 more sources

Safety Assessment and Hypoglycemic Effect of Moringa oleifera Lam. Seed Lectin (WSMoL) in Alloxan‐Induced Diabetic Mice

Journal of Applied Toxicology, EarlyView.
ABSTRACT Moringa oleifera Lam. seeds contain WSMoL, a lectin previously studied for toxicity and pharmacological effects. In this study, we investigated WSMoL (10, 25, or 50 mg/kg i.p.) for acute and 14‐day repeated‐dose toxicity, as well as genotoxicity, in Swiss mice.
Alícia Natalie Silva dos Santos, Matheus Cavalcanti de Barros, Cleidiane Silva Vieira de Souza, Ryan Cristian da Silva, Luana Cassandra Breitenbach Barroso Coelho, Maria Tereza dos Santos Correia, Fernanda das Chagas Ângelo Mendes Tenório, Alisson Macário de Oliveira, Thiago Henrique Napoleão, Robson Raion de Vasconcelos Alves, Patrícia Maria Guedes Paiva   +10 more
wiley   +1 more source

In vitro expanded stem cells from the developing retina fail to generate photoreceptors but differentiate into myelinating oligodendrocytes.

PLoS ONE, 2012
Cell transplantation to treat retinal degenerative diseases represents an option for the replacement of lost photoreceptor cells. In vitro expandable cells isolated from the developing mammalian retina have been suggested as a potential source for the ...
Magdalena Czekaj, Jochen Haas, Marlen Gebhardt, Thomas Müller-Reichert, Peter Humphries, Jane Farrar, Udo Bartsch, Marius Ader   +7 more
doaj   +1 more source

Molecular characterization of retinal stem cells and their niches in adult zebrafish [PDF]

, 2015
Background The persistence in adult teleost fish of retinal stem cells that exhibit all of the features of true 'adult stem cells' – self-renewal, multipotency, and the capacity to respond to injury by mitotic activation with the ability ...
Barthel, Linda K, Bernardos, Rebecca L, Perkowski, John J, Raymond, Pamela A   +3 more
core   +1 more source

Diabetic Peripheral Neuropathy: Molecular Staging, Risk Factors, Therapeutics, and Emerging Trends

Med Research, EarlyView.
The heterogeneous landscape of DPN can be unified through a tripartite pathogenic model encompassing progressive stages of metabolic dysregulation, chronic inflammation, and overt neuronal damage. Within this framework, six clinical subtypes were identified, namely, hyperglycemia‐driven, dyslipidemia‐driven, inflammation‐driven, dysvascularity‐driven ...
Xiaofeng Dai, Mingze Tang
wiley   +1 more source

Brain Pericytes and Wnt/β‐Catenin Signaling Induce Functional Blood–Brain Barrier Phenotype in Human iPSC‐Derived Model

Small Methods, EarlyView.
This study shows that human iPSC‐derived endothelial cells acquire a functional blood–brain barrier phenotype when co‐cultured with brain pericytes and stimulated with CHIR‐99021, a Wnt/β‐catenin activator. This model recapitulates key barrier properties, inflammatory responses, and transcriptomic features of the native human BBB, offering new ...
Henrique Nogueira Pinto, Nine R. Kok, Philipp C. Hauger, Manon Karsten‐van Diepen, Michael de Kok, Nanne J. Paauw, Susanne M. A. van der Pol, Joline P. Nugteren‐Boogaard, Peter L. Hordijk, Stephanie D. Beekhuis‐Hoekstra, Susan Gibbs, Nienke M. de Wit, Helga E. de Vries   +12 more
wiley   +1 more source

Retinal stem/progenitor properties of iris pigment epithelial cells

Developmental Biology, 2006
Neural stem cells/progenitors that give rise to neurons and glia have been identified in different regions of the brain, including the embryonic retina and ciliary epithelium of the adult eye. Here, we first demonstrate the characterization of neural stem/progenitors in postnatal iris pigment epithelial (IPE) cells.
Sun, Guangwei, Asami, Maki, Ohta, Hiroshi, Kosaka, Jun, Kosaka, Mitsuko   +4 more
openaire   +2 more sources

Endothelial progenitor cells in diabetic retinopathy [PDF]

, 2014
Diabetic retinopathy (DR) is a leading cause of visual impairment worldwide. Patients with DR may irreversibly lose sight as a result of the development of diabetic macular oedema (DMO) and/or proliferative diabetic retinopathy (PDR); retinal blood ...
Adamis, Arnold, Asahara, Asahara, Assmus, Basile, Beitnes, Bhatwadekar, Brunner, Brunner, Busik, Ceradini, Ceradini, Chakravarthy, Chen, Curtis, Do, Elman, Fadini, Fadini, Fong, Group, Hardarson, Heeschen, Hirsch, Hoetzer, Hur, Ingram, Ingram, Ingram, Janssens, Jenkins, Jie, Jørgensen, Kawamoto, Khoo, Kim, Klein, Kocur, Kusuyama, Lakhani, Lee, Lee, Linskens, Liu, Lombardo, Loomans, Lyons, Mandecka, Masuda, Medina, Medina, Medina, Medina, Mendel, Miller, Mitchell, Motaghiannezam, Nguyen, O’Neill, Rehman, Reinhard, Reinisch, Resnikoff, Rudrappa, Sharma, Shimada, Stitt, Strijbos, Takahashi, Tan, Tepper, van Ark, Vasa, Vigstrup, Werner, Wessel, Wessel, West, Wolfram, Yasuno, Yoder, Zerbini, Zheng, Zietz   +84 more
core   +2 more sources

Staging concept for aging management: Definition, mechanism, and coping strategies

VIEW, EarlyView.
We divided the overall aging stage into “pre‐aging”, “aging compensation”, and “aging disability”. For each stage, we delineate the clinical presentations, biological phenomena, theoretical underpinnings, and key management priorities. Abstract Aging, as a gradual and largely irreversible biological process, characterized by declining organismal ...
Zhonghan Wang, Shixian Liu, Shangyu Du, Xiangran Cui, Bo Chao, Minglei Liu, Minfei Wu   +6 more
wiley   +1 more source