Results 111 to 120 of about 5,449,684 (261)
Protein Glutamylation: From Cytoskeleton to Signaling
Med Research, EarlyView.Tubulin glutamylation, γ‐glutamylation, and nontubulin glutamylation are distinct yet interconnected post‐translational modifications that regulate diverse physiological and pathological processes, including cytoskeletal organization, cell cycle progression, immunity, metabolism, and disease development.
Jiayuan Chen +4 more
wiley +1 more source
Journal of Tissue Engineering, 2014 Tissue engineering has been widely applied in different areas of regenerative medicine, including retinal regeneration. Typically, artificial biopolymers require additional surface modification (e.g. with arginine–glycine–aspartate-containing peptides or
Petr Baranov +4 more
doaj +1 more source
Induction of rod versus cone photoreceptor-specific progenitors from retinal precursor cells
Stem Cell Research, 2018 During development, multipotent progenitors undergo temporally-restricted differentiation into post-mitotic retinal cells; however, the mechanisms of progenitor division that occurs during retinogenesis remain controversial.
Saeed Khalili +12 more
doaj +1 more source
Senotherapeutics for Knee Osteoarthritis
Medicinal Research Reviews, EarlyView.ABSTRACT Osteoarthritis (OA) is a chronic disease that imposes a significant economic burden and deteriorates quality of life. Nevertheless, current therapeutic options for OA are limited to symptomatic remedies. As such, there is a high interest in novel methods for treating or preventing OA.
Ezgi Duman +6 more
wiley +1 more source
Genomic analysis of mouse retinal development.
PLoS Biology, 2004 The vertebrate retina is comprised of seven major cell types that are generated in overlapping but well-defined intervals. To identify genes that might regulate retinal development, gene expression in the developing retina was profiled at multiple time ...
Seth Blackshaw +14 more
doaj +1 more source
Navigating the Complexity: A Comprehensive Review of GSK‐3 Inhibition in Regenerative Medicine
Medicinal Research Reviews, EarlyView.ABSTRACT Glycogen synthase kinase‐3 (GSK‐3) is a central regulator of numerous cellular signaling pathways, with critical roles in metabolism, proliferation, differentiation, and tissue regeneration. This review explores the multifaceted effects of pharmacological GSK‐3 inhibition across multiple body districts, focusing on its highly context‐dependent
Davide Schiroli +5 more
wiley +1 more source
, 2015 Maintaining a discrete population of retinal progenitors in the circumferential marginal zone (CMZ) is required for proper growth of a functional vertebrate retina after embryogenesis.
Sorfazlian, Natalie
core
Hematopoietic Signaling Mechanism Revealed from a Stem/Progenitor Cell Cistrome
, 2015 Thousands of cis-elements in genomes are predicted to have vital functions. Although conservation, activity in surrogate assays, polymorphisms, and disease mutations provide functional clues, deletion from endogenous loci constitutes the gold-standard ...
Rajendran Sanalkumar +23 more
core +1 more source
V-ATPase Regulates Retinal Progenitor Cell Proliferation During Eye Regrowth in Xenopus. [PDF]
J Ocul Pharmacol Ther, 2023 Kha CX, Nava I, Tseng KA.
europepmc +1 more source
Neuroprotection, EarlyView.Abstract Prime editing, a novel clustered regularly interspaced short palindromic repeats (CRISPR)‐based technology, fuses a reverse transcriptase (RT) to an engineered CRISPR‐associated protein 9 (Cas9) and uses a prime editing guide RNA (pegRNA)‐encoded template.
Tianshan Ji +4 more
wiley +1 more source