Results 1 to 10 of about 93,615 (295)

Living with heritable retinoblastoma and the perceived role of regular follow-up at a retinoblastoma survivorship clinic: ‘That is exactly what I have been missing’

BMJ Open Ophthalmology, 2021
Objective To explore living with heritable retinoblastoma, specifically survivors’ perceived role of regular follow-up at a retinoblastoma survivorship clinic.Methods and analysis Adult survivors of heritable retinoblastoma were recruited from the ...
Stina Lou, Pernille Axel Gregersen, Mikkel Funding, Steen F Urbak, Jan Alsner, Maja H Olsen, Jens Overgaard, Sandra E Staffieri   +7 more
doaj   +1 more source

Incidence and geographic distribution of retinoblastoma in Ethiopia

BMC Ophthalmology, 2023
Introduction Retinoblastoma is the most frequent intraocular malignancy of the eye in children, occurring in early childhood. Based on global estimates, Ethiopia is expected to observe over 200 new retinoblastoma cases per year, however without a cancer ...
Sadik Taju Sherief, Gadisa Asfaw, Aemero Abateneh, Solomon Takewe, Diriba Fufa, Teshager Wondale, Temesgen Takele, Helen Dimaras   +7 more
doaj   +1 more source

Sclero-conjunctival ischaemia secondary to intra-arterial chemotherapy for retinoblastoma

American Journal of Ophthalmology Case Reports, 2020
Purpose: Intra-arterial chemotherapy (IAC), delivered directly to the globe via the internal carotid artery is now an established treatment for retinoblastoma.
Lisa McAnena, Zishan Naeem, Catriona Duncan, Fergus Robertson, Mandeep S. Sagoo, M. Ashwin Reddy   +5 more
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Single-cell transcriptome profiling reveals intratumoural heterogeneity and malignant progression in retinoblastoma

Cell Death and Disease, 2021
Retinoblastoma is a childhood retinal tumour that is the most common primary malignant intraocular tumour. However, it has been challenging to identify the cell types associated with genetic complexity. Here, we performed single-cell RNA sequencing on 14,
Jie Yang, Yongyun Li, Yanping Han, Yiyi Feng, Min Zhou, Chunyan Zong, Xiaoyu He, Renbing Jia, Xiaofang Xu, Jiayan Fan   +9 more
doaj   +1 more source

Patients, Public and Service Users are Experts by Experience: An Overview from Ophthalmology Research in Canada, UK and Beyond

Ophthalmology and Therapy, 2020
Plain Language Summary Through living with conditions and/or engaging with health and social care services patients, public and service users become experts by experience.
Andrew M. Skilton, Leslie G. Low, Helen Dimaras   +2 more
doaj   +1 more source

Lag time, high-risk histopathological features, metastasis, and survival interrelation in retinoblastoma: a perspective from lower-middle income country [PDF]

International Journal of Ophthalmology, 2022
AIM: To investigate the impact of lag time to metastasis and survival rates among patients with retinoblastoma. METHODS: This retrospective study was conducted with 52 patients from the Department of Ophthalmology and the Department of Pediatrics of Dr ...
Purjanto Tepo Utomo, Datu Respatika, Bambang Ardianto, Hanggoro Tri Rinonce, Didik Setyo Heriyanto, Banu Aji Dibyasakti, Irene Titin Darajati, Indra Tri Mahayana, Agus Supartoto   +8 more
doaj   +1 more source

Bone metastasis of retinoblastoma five years after primary treatment

American Journal of Ophthalmology Case Reports, 2020
Purpose: Histopathological, immunohistochemistry- and molecular pathology-based diagnostics to distinguish metastasis of retinoblastoma from subsequent primary malignancy in patients with heritable retinoblastoma.
Saskia C. Ting, Tobias Kiefer, Karoline Ehlert, Sophia L. Goericke, Raoul Hinze, Petra Ketteler, Nikolaos E. Bechrakis, Hans-Ulrich Schildhaus   +7 more
doaj   +1 more source

mTOR inhibition by TAK‐228 is effective against growth, survival and angiogenesis in preclinical retinoblastoma models

Pharmacology Research & Perspectives, 2022
We and others have shown that aberrant activation of the mammalian target of rapamycin (mTOR) signalling is essential for retinoblastoma progression and has potential therapeutic value.
Lanlan Tang, Yu Fu, Jiarun Song, Taibing Hu, Kun Li, Zhi Li   +5 more
doaj   +1 more source

Retinoblastoma: A review of the molecular basis of tumor development and its clinical correlation in shaping future targeted treatment strategies

Indian Journal of Ophthalmology, 2023
Retinoblastoma is a retinal cancer that affects children and is the most prevalent intraocular tumor worldwide. Despite tremendous breakthroughs in our understanding of the fundamental mechanisms that regulate progression of retinoblastoma, the ...
Shruti Rathore, Aman Verma, Ria Ratna, Navjot Marwa, Yagya Ghiya, Santosh G Honavar, Anil Tiwari, Sima Das, Akhil Varshney   +8 more
doaj   +1 more source

Longer Lag Time in Early-Stage Retinoblastoma

Folia Medica Indonesiana, 2022
Highlights: • Patients with IRSS I stage have the longest lag time than IVB stage. • Lag time is no significant with stage retinoblastoma.   Abstract: Retinoblastoma is a rare neoplasm disease that occurs in children, generally under the age of ...
Anindya Citra, Budi Utomo, Hendrian Dwikoloso Soebagjo   +2 more
doaj   +1 more source