Results 1 to 10 of about 145,462 (345)

Mutation and Cancer: Statistical Study of Retinoblastoma

Proceedings of the National Academy of Sciences of the United States of America, 1971
Based upon observations on 48 cases of retinoblastoma and published reports, the hypothesis is developed that retinoblastoma is a cancer caused by two mutational events.
Alfred G. Knudson
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CD171- and GD2-specific CAR-T cells potently target retinoblastoma cells in preclinical in vitro testing [PDF]

BMC Cancer, 2019
BACKGROUND: Chimeric antigen receptor (CAR)-based T cell therapy is in early clinical trials to target the neuroectodermal tumor, neuroblastoma. No preclinical or clinical efficacy data are available for retinoblastoma to date.
Andersch, Lena, Eggert, Angelika, Flemmig, Carina, Grunewald, Laura, Henssen, Anton, Jensen, Michael C., Joussen, Antonia, Klaus, Anika, Künkele, Annette, Radke, Josefine, Rossig, Claudia, Schulte, Johannes H., Schumann, Elisa, Schwiebert, Silke, Winkler, Annika, Zirngibl, Felix   +15 more
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Non-coding and Coding Transcriptional Profiles Are Significantly Altered in Pediatric Retinoblastoma Tumors. [PDF]

Frontiers in Oncology, 2019
Retinoblastoma is a rare pediatric tumor of the retina, caused by the homozygous loss of the Retinoblastoma 1 (RB1) tumor suppressor gene. Previous microarray studies have identified changes in the expression profiles of coding genes; however, our ...
Bisht, Madhoolika, Campbell, Moray J, Dotts, Kathleen, Elchuri, Sailaja V, Khetan, Vikas, Krishnakumar, Subrmanian, Kumar, Ranjith, Miles, Wayne O, Nagarajha Selvan, Lakshmi Dhevi, Rajasekaran, Swetha, Rishi, Pukhraj, Sahoo, Debashis, Sivaraman, Karthikeyan   +12 more
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Retinoblastoma, the visible CNS tumor: A review [PDF]

Journal of Neuroscience Research, 2018
The pediatric ocular cancer retinoblastoma is the only central nervous system (CNS) tumor readily observed without specialized equipment: it can be seen by, and in, the naked eye. This accessibility enables unique imaging modalities. Here, we review this
Corson, Timothy W., Dimaras, Helen
core   +2 more sources

Update on pathology of retinoblastoma [PDF]

International Journal of Ophthalmology, 2018
Retinoblastoma is caused by mutational inactivation of both alleles of the RB1 gene, which maps to chromosome 13q14 and encodes retinoblastoma protein that acts as a tumor suppressor.
Lata Singh, Seema Kashyap
doaj   +2 more sources

The management of retinoblastoma

Oncogene, 2018
Retinoblastoma (Rb) is the most common primary intraocular malignancy of childhood, but an uncommon paediatric cancer, with a constant incidence worldwide of 1:15,000-1:20,000 live births. Despite its rarity, Rb has served as a cornerstone in the field of oncology in many of the aspects that comprise cancer management, including classification schemes,
I. Fabian, I. Fabian, I. Fabian, Z. Onadim, E. Karaa, C. Duncan, C. Duncan, Tanzina Chowdhury, Tanzina Chowdhury, I. Scheimberg, S. Ohnuma, M. A. Reddy, M. A. Reddy, M. Sagoo, M. Sagoo, M. Sagoo   +15 more
semanticscholar   +4 more sources

Differentiating MYCN-amplified RB1 wild-type retinoblastoma from biallelic RB1 mutant retinoblastoma using MR-based radiomics: a retrospective multicenter case–control study [PDF]

Scientific Reports
MYCN-amplified RB1 wild-type (MYCN amp RB1 +/+) retinoblastoma is a rare and aggressive subtype, often resistant to standard therapies. Identifying unique MRI features is crucial for diagnosing this subtype, as biopsy is not recommended. This study aimed
Christiaan M. de Bloeme , Robin W. Jansen, Liesbeth Cardoen, Sophia Göricke, Sabien van Elst, Jaime Lyn Jessen, Aparna Ramasubramanian, Alison H. Skalet, Audra K. Miller, Philippe Maeder, Ogul E. Uner, G. Baker Hubbard, Hans Grossniklaus, H. Culver Boldt, Kim E. Nichols, Rachel C. Brennan, Saugata Sen, Mériam Koob, Selma Sirin, Hervé J. Brisse, Paolo Galluzzi, Charlotte J. Dommering, Matthijs Cysouw, Ronald Boellaard, Josephine C. Dorsman, Annette C. Moll, Marcus C. de Jong, Pim de Graaf, European Retinoblastoma Imaging Collaboration   +28 more
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Neonatal retinoblastoma

Asia-Pacific Journal of Oncology Nursing, 2017
From 7% to 10% of all retinoblastomas and from 44% to 71% of familial retinoblastomas in developed countries are diagnosed in the neonatal period, usually through pre- or post-natal screening prompted by a positive family history and sometimes ...
Tero T Kivelä, Theodora Hadjistilianou
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The retinoblastoma protein associates with the protein phosphatase type 1 catalytic subunit. [PDF]

Genes & Development, 1993
The retinoblastoma protein (p110RB) interacts with many cellular proteins in complexes potentially important for its growth-suppressing function. We have developed and used an improved version of the yeast two-hybrid system to isolate human cDNAs ...
T. Durfee, Kathleen Becherer, Phang‐Lang Chen, S.-H. Yeh, Yijing Yang, April E. Kilburn, W H Lee, Stephen J. Elledge   +7 more
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Retinoblastoma [PDF]

Revista chilena de pediatría, 1979
Retinoblastoma is a radiosensitive malignancy of neuroblastic origin that primarily affects young children. Its relatively low incidence belies its potential importance in the understanding of tumor biology in general. A case is made for referral of all retinoblastoma patients to centers with retinoblastoma protocols.
Marchevsky, Silvia, Beresi, Victoria, Quintana, Juan, del Pozo, Humberto, Charlin, Carlos   +4 more
openaire   +5 more sources