Results 1 to 10 of about 138,409 (281)
CD171- and GD2-specific CAR-T cells potently target retinoblastoma cells in preclinical in vitro testing [PDF]
BMC Cancer, 2019 Background Chimeric antigen receptor (CAR)-based T cell therapy is in early clinical trials to target the neuroectodermal tumor, neuroblastoma. No preclinical or clinical efficacy data are available for retinoblastoma to date.
Lena Andersch +15 more
doaj +5 more sources
RB1 Sequence Variants in Retinoblastoma: Analysis of RB1 Variants in a Database for Correlation with pRB Protein Domains and Clinical Presentation [PDF]
BiomedicinesBackground: Retinoblastoma (RB) is the most common pediatric ocular tumor that occurs due to the biallelic inactivation of the RB1 tumor suppressor gene. RB may be unilateral or bilateral and is hereditary in 50% of cases. An inactivation of the RB1 gene
Nicohol Tovar Martelo, Irene Szijan
doaj +2 more sources
Asia-Pacific Journal of Oncology Nursing, 2017 From 7% to 10% of all retinoblastomas and from 44% to 71% of familial retinoblastomas in developed countries are diagnosed in the neonatal period, usually through pre- or post-natal screening prompted by a positive family history and sometimes ...
Tero T Kivelä, Theodora Hadjistilianou
doaj +6 more sources
Update on pathology of retinoblastoma [PDF]
International Journal of Ophthalmology, 2018 Retinoblastoma is caused by mutational inactivation of both alleles of the RB1 gene, which maps to chromosome 13q14 and encodes retinoblastoma protein that acts as a tumor suppressor.
Lata Singh, Seema Kashyap
doaj +2 more sources
Recent Developments in Retinoblastoma
Delhi Journal of Ophthalmology, 2016 Retinoblastoma represents 3% of all childhood cancers, and is the most common intraocular malignancy of childhood. It is fatal if untreated. The management of retinoblastoma has gradually evolved over the past few decades, with an aim to not only ...
Raksha Rao, Santosh G Honavar
doaj +3 more sources
Nature Reviews Disease Primers, 2015 Retinoblastoma is a rare cancer of the infant retina that is diagnosed in approximately 8,000 children each year worldwide. It forms when both retinoblastoma gene (RB1) alleles are mutated in a susceptible retinal cell, probably a cone photoreceptor precursor.
Dimaras, Helen +10 more
+9 more sources
Explainable AI for Retinoblastoma Diagnosis: Interpreting Deep Learning Models with LIME and SHAP
Diagnostics, 2023 Retinoblastoma is a rare and aggressive form of childhood eye cancer that requires prompt diagnosis and treatment to prevent vision loss and even death. Deep learning models have shown promising results in detecting retinoblastoma from fundus images, but
C. Chiesa-Estomba +5 more
semanticscholar +1 more source
Treatment of Retinoblastoma: What Is the Latest and What Is the Future
Frontiers in Oncology, 2022 The management of retinoblastoma, the most common intraocular malignancy in children, has changed drastically over the last decade. Landmark developments in local drug delivery, namely, safer techniques for intravitreal chemotherapy injection and ...
P. Schaiquevich +5 more
semanticscholar +1 more source
BMJ Open Ophthalmology, 2021 Objective To explore living with heritable retinoblastoma, specifically survivors’ perceived role of regular follow-up at a retinoblastoma survivorship clinic.Methods and analysis Adult survivors of heritable retinoblastoma were recruited from the ...
Stina Lou +7 more
doaj +1 more source
Revista chilena de pediatría, 1979 Retinoblastoma is a radiosensitive malignancy of neuroblastic origin that primarily affects young children. Its relatively low incidence belies its potential importance in the understanding of tumor biology in general. A case is made for referral of all retinoblastoma patients to centers with retinoblastoma protocols.
Marchevsky, Silvia +4 more
openaire +5 more sources