Results 21 to 30 of about 57,195 (184)
Pharmacology Research & Perspectives, 2022 We and others have shown that aberrant activation of the mammalian target of rapamycin (mTOR) signalling is essential for retinoblastoma progression and has potential therapeutic value.
Lanlan Tang +5 more
doaj +1 more source
CRISPR/Cas9 mediated knockout of rb1 and rbl1 leads to rapid and penetrant retinoblastoma development in Xenopus tropicalis [PDF]
, 2016 Retinoblastoma is a pediatric eye tumor in which bi-allelic inactivation of the Retinoblastoma 1 (RB1) gene is the initiating genetic lesion. Although recently curative rates of retinoblastoma have increased, there are at this time no molecular targeted ...
Boel, Annekatrien +12 more
core +2 more sources
The Lancet, 2012 Retinoblastoma is an aggressive eye cancer of infancy and childhood. Survival and the chance of saving vision depend on severity of disease at presentation. Retinoblastoma was the first tumour to draw attention to the genetic aetiology of cancer. Despite good understanding of its aetiology, mortality from retinoblastoma is about 70% in countries of low
Gallie Brenda L. +6 more
openaire +3 more sources
Indian Journal of Ophthalmology, 2023 Retinoblastoma is a retinal cancer that affects children and is the most prevalent intraocular tumor worldwide. Despite tremendous breakthroughs in our understanding of the fundamental mechanisms that regulate progression of retinoblastoma, the ...
Shruti Rathore +8 more
doaj +1 more source
Journal of Education, Health and Sport, 2018 Budny Agnieszka, Grochowski Cezary. Retinoblastoma. Journal of Education, Health and Sport. 2018;8(7):204-213. eISNN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.1299573 http://ojs.ukw.edu.pl/index.php/johs/article/view/5611 https://pbn.nauka.gov.pl/sedno-webapp/works/868825 The journal has had 7 points in Ministry of Science and ...
Agnieszka Budny, Cezary Grochowski
openaire +4 more sources
BTG interacts with retinoblastoma to control cell fate in Dictyostelium. [PDF]
, 2010 In the genesis of many tissues, a phase of cell proliferation is followed by cell cycle exit and terminal differentiation. The latter two processes overlap: genes involved in the cessation of growth may also be important in triggering differentiation ...
Ceccarelli, Adriano +2 more
core +7 more sources
Retinoblastoma and vision [PDF]
Eye, 2022 AbstractThe assessment of vision has a growing importance in the management of retinoblastoma in the era of globe-conserving therapy, both prior to and after treatment. As survival rates approach 98–99% and globe salvage rates reach ever-higher levels, it is important to provide families with information regarding the visual outcomes of different ...
Omar Warda +4 more
openaire +3 more sources
Retinoblastoma in Late Childhood
Journal of Nepal Medical Association, 2003 Retinoblastoma, the commonest intra-ocular tumor of childhood, is rare after the age of 5 years. We report a case of retinoblastoma in a 10 year-old boy, who presented with a fungating proptosed tender mass involving the entire left eye and the orbit.
B Badhu, S P Sah, S Kumar, R P Sah
doaj +1 more source
Phosphorylation of pRb: mechanism for RB pathway inactivation in MYCN-amplified retinoblastoma. [PDF]
, 2017 A small, but unique subgroup of retinoblastoma has been identified with no detectable mutation in the retinoblastoma gene (RB1) and with high levels of MYCN gene amplification.
Bhatti, Tricia R. +6 more
core +2 more sources
Update on pathology of retinoblastoma [PDF]
International Journal of Ophthalmology, 2018 Retinoblastoma is caused by mutational inactivation of both alleles of the RB1 gene, which maps to chromosome 13q14 and encodes retinoblastoma protein that acts as a tumor suppressor.
Lata Singh, Seema Kashyap
doaj +1 more source