Results 31 to 40 of about 151,276 (329)
Cell Death and Disease, 2021 Retinoblastoma is a childhood retinal tumour that is the most common primary malignant intraocular tumour. However, it has been challenging to identify the cell types associated with genetic complexity. Here, we performed single-cell RNA sequencing on 14,
Jie Yang +9 more
doaj +1 more source
Ophthalmology and Therapy, 2020 Plain Language Summary Through living with conditions and/or engaging with health and social care services patients, public and service users become experts by experience.
Andrew M. Skilton +2 more
doaj +1 more source
Modern treatment of retinoblastoma: A 2020 review
Indian Journal of Ophthalmology, 2020 Retinoblastoma management remains complex, requiring individualized treatment based on International Classification of Retinoblastoma (ICRB) staging, germline mutation status, family psychosocial factors and cultural beliefs, and available institutional ...
D. Ancona-Lezama, L. Dalvin, C. Shields
semanticscholar +1 more source
Lag time, high-risk histopathological features, metastasis, and survival interrelation in retinoblastoma: a perspective from lower-middle income country [PDF]
International Journal of Ophthalmology, 2022 AIM: To investigate the impact of lag time to metastasis and survival rates among patients with retinoblastoma. METHODS: This retrospective study was conducted with 52 patients from the Department of Ophthalmology and the Department of Pediatrics of Dr ...
Purjanto Tepo Utomo +8 more
doaj +1 more source
CRISPR/Cas9 mediated knockout of rb1 and rbl1 leads to rapid and penetrant retinoblastoma development in Xenopus tropicalis [PDF]
, 2016 Retinoblastoma is a pediatric eye tumor in which bi-allelic inactivation of the Retinoblastoma 1 (RB1) gene is the initiating genetic lesion. Although recently curative rates of retinoblastoma have increased, there are at this time no molecular targeted ...
Boel, Annekatrien +12 more
core +2 more sources
The Lancet, 2012 Retinoblastoma is an aggressive eye cancer of infancy and childhood. Survival and the chance of saving vision depend on severity of disease at presentation. Retinoblastoma was the first tumour to draw attention to the genetic aetiology of cancer. Despite good understanding of its aetiology, mortality from retinoblastoma is about 70% in countries of low
Gallie Brenda L. +6 more
openaire +3 more sources
Retinoblastoma: Etiology, Modeling, and Treatment
Cancers, 2020 Retinoblastoma is a retinal cancer that is initiated in response to biallelic loss of RB1 in almost all cases, together with other genetic/epigenetic changes culminating in the development of cancer. RB1 deficiency makes the retinoblastoma cell-of-origin
R. Kaewkhaw, Duangnate Rojanaporn
semanticscholar +1 more source
Retinoblastoma and vision [PDF]
Eye, 2022 AbstractThe assessment of vision has a growing importance in the management of retinoblastoma in the era of globe-conserving therapy, both prior to and after treatment. As survival rates approach 98–99% and globe salvage rates reach ever-higher levels, it is important to provide families with information regarding the visual outcomes of different ...
Omar Warda +4 more
openaire +3 more sources
Bone metastasis of retinoblastoma five years after primary treatment
American Journal of Ophthalmology Case Reports, 2020 Purpose: Histopathological, immunohistochemistry- and molecular pathology-based diagnostics to distinguish metastasis of retinoblastoma from subsequent primary malignancy in patients with heritable retinoblastoma.
Saskia C. Ting +7 more
doaj +1 more source
Pharmacology Research & Perspectives, 2022 We and others have shown that aberrant activation of the mammalian target of rapamycin (mTOR) signalling is essential for retinoblastoma progression and has potential therapeutic value.
Lanlan Tang +5 more
doaj +1 more source