Results 31 to 40 of about 145,462 (345)

CRISPR/Cas9 mediated knockout of rb1 and rbl1 leads to rapid and penetrant retinoblastoma development in Xenopus tropicalis [PDF]

, 2016
Retinoblastoma is a pediatric eye tumor in which bi-allelic inactivation of the Retinoblastoma 1 (RB1) gene is the initiating genetic lesion. Although recently curative rates of retinoblastoma have increased, there are at this time no molecular targeted ...
Boel, Annekatrien, Colpaert, Robin, Creytens, David, Deforce, Dieter, Dimitrakopoulou, Dionysia, Haustraete, Jurgen, L, J, Lepez, Trees, Naert, Thomas, Steyaert, Wouter, Van Nieuwenhuysen, Tom, Vleminckx, Kris, Willaert, Andy   +12 more
core   +2 more sources

Retinoblastoma

The Lancet, 2012
Retinoblastoma is an aggressive eye cancer of infancy and childhood. Survival and the chance of saving vision depend on severity of disease at presentation. Retinoblastoma was the first tumour to draw attention to the genetic aetiology of cancer. Despite good understanding of its aetiology, mortality from retinoblastoma is about 70% in countries of low
Gallie Brenda L., Chan Helen S., White Abby., Gronsdahl Peggy., Dimba Elizabeth A., Kimani Kahaki., Dimaras Helen.   +6 more
openaire   +3 more sources

mTOR inhibition by TAK‐228 is effective against growth, survival and angiogenesis in preclinical retinoblastoma models

Pharmacology Research & Perspectives, 2022
We and others have shown that aberrant activation of the mammalian target of rapamycin (mTOR) signalling is essential for retinoblastoma progression and has potential therapeutic value.
Lanlan Tang, Yu Fu, Jiarun Song, Taibing Hu, Kun Li, Zhi Li   +5 more
doaj   +1 more source

Retinoblastoma: A review of the molecular basis of tumor development and its clinical correlation in shaping future targeted treatment strategies

Indian Journal of Ophthalmology, 2023
Retinoblastoma is a retinal cancer that affects children and is the most prevalent intraocular tumor worldwide. Despite tremendous breakthroughs in our understanding of the fundamental mechanisms that regulate progression of retinoblastoma, the ...
Shruti Rathore, Aman Verma, Ria Ratna, Navjot Marwa, Yagya Ghiya, Santosh G Honavar, Anil Tiwari, Sima Das, Akhil Varshney   +8 more
doaj   +1 more source

Analysis of hope level and its influencing factors in patients with decompensated cirrhosis

Nursing Open, Volume 10, Issue 2, Page 623-629, February 2023., 2023
Abstract Aim The aim of this study was to examine hope level and its influencing factors in patients with decompensated liver cirrhosis. Design A prospective observational study. Methods We selected 93 patients with decompensated liver cirrhosis from a Chinese university hospital based on the inclusion and exclusion criteria.
Yuanyuan Zhang, Ling Xie, Fen Li, Chunyan Huo, Yanling Miao, Lining Wang, Caiyan Ding   +6 more
wiley   +1 more source

Retinoblastoma: Etiology, Modeling, and Treatment

Cancers, 2020
Retinoblastoma is a retinal cancer that is initiated in response to biallelic loss of RB1 in almost all cases, together with other genetic/epigenetic changes culminating in the development of cancer. RB1 deficiency makes the retinoblastoma cell-of-origin
R. Kaewkhaw, Duangnate Rojanaporn
semanticscholar   +1 more source

Retinoblastoma

Journal of Education, Health and Sport, 2018
Budny Agnieszka, Grochowski Cezary. Retinoblastoma. Journal of Education, Health and Sport. 2018;8(7):204-213. eISNN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.1299573 http://ojs.ukw.edu.pl/index.php/johs/article/view/5611 https://pbn.nauka.gov.pl/sedno-webapp/works/868825 The journal has had 7 points in Ministry of Science and ...
Agnieszka Budny, Cezary Grochowski
openaire   +4 more sources

Delving Into Retinoblastoma Genetics: Discovery of Novel Mutations and Their Clinical Impact: Retrospective Cohort Study. [PDF]

Cancer Med
A comprehensive outline of the study, detailing the process from DNA extraction to the evaluation of RB1 mutations in relation to clinical features and patient outcomes. ABSTRACT Background Retinoblastoma (Rb) is a rare intraocular malignancy that originates in the retina of children under 5 years of age.
Faranoush M, Naseripour M, Faranoush P, Davoodi-Moghaddam Z, Jahandideh A, Sadighnia N, Daneshjou D, Shams P, Sedaghat A, Mirshahi R, Ravanbod S, Nasirnejad F, Elahinia A, Bashash D.   +13 more
europepmc   +2 more sources

Retinoblastoma and vision [PDF]

Eye, 2022
AbstractThe assessment of vision has a growing importance in the management of retinoblastoma in the era of globe-conserving therapy, both prior to and after treatment. As survival rates approach 98–99% and globe salvage rates reach ever-higher levels, it is important to provide families with information regarding the visual outcomes of different ...
Omar Warda, Zishan Naeem, Kelsey A. Roelofs, Mandeep S. Sagoo, M. Ashwin Reddy   +4 more
openaire   +3 more sources

BTG interacts with retinoblastoma to control cell fate in Dictyostelium. [PDF]

, 2010
In the genesis of many tissues, a phase of cell proliferation is followed by cell cycle exit and terminal differentiation. The latter two processes overlap: genes involved in the cessation of growth may also be important in triggering differentiation ...
Ceccarelli, Adriano, Conte, Daniele, MacWilliams, Harry K.   +2 more
core   +6 more sources