Results 31 to 40 of about 93,615 (295)
OncoTargets and Therapy, 2020 Background MicroRNAs (miRNAs) have been shown to contribute to the initiation and progression of human cancer, including retinoblastoma. However, expression levels and potential roles of miRNAs in retinoblastoma remain largely unknown.
Lidong Yang +3 more
semanticscholar +1 more source
Retinoblastoma in Late Childhood
Journal of Nepal Medical Association, 2003 Retinoblastoma, the commonest intra-ocular tumor of childhood, is rare after the age of 5 years. We report a case of retinoblastoma in a 10 year-old boy, who presented with a fungating proptosed tender mass involving the entire left eye and the orbit.
B Badhu, S P Sah, S Kumar, R P Sah
doaj +1 more source
Cancer Medicine, 2020 The enucleation rate for retinoblastoma has dropped from over 95% to under 10% in the past 10 years as a result of improvements in therapy. This reduces access to tumor tissue for molecular profiling, especially in unilateral retinoblastoma, and hinders ...
Prachi Kothari +17 more
semanticscholar +1 more source
Analysis of MDM2 and MDM4 single nucleotide polymorphisms, mRNA splicing and protein expression in retinoblastoma. [PDF]
PLoS ONE, 2012 Retinoblastoma is a childhood cancer of the developing retina that begins in utero and is diagnosed in the first years of life. Biallelic RB1 gene inactivation is the initiating genetic lesion in retinoblastoma.
Justina McEvoy +6 more
doaj +1 more source
Retinoblastoma genetics in India: From research to implementation
Indian Journal of Ophthalmology, 2015 Retinoblastoma is the prototypic genetic cancer. India carries the biggest burden of retinoblastoma globally, with an estimated 1500 new cases annually.
Helen Dimaras
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A rare case of adult onset retinoblastoma
Oman Journal of Ophthalmology, 2011 Retinoblastoma usually manifests before five years of age. Retinoblastoma in an adult is extremely rare. Twenty-three cases of retinoblastoma in adults 20 years or older have been reported in world literature.
Sunil Kumar Singh +7 more
doaj +1 more source
Retinoblastoma Tumor Suppressor Protein Roles in Epigenetic Regulation
Cancers, 2020 Simple Summary Loss of function of the retinoblastoma gene (RB1) is the rate-limiting step in the initiation of both the hereditary and sporadic forms of retinoblastoma tumor.
Frederick Guzman +5 more
semanticscholar +1 more source
Nigerian Journal of Medicine, 2022 Background: Retinoblastoma, although rare, is the most frequently occurring primary intraocular tumor of childhood. While a cure is often achieved where appropriate treatment is instituted early in the disease, late presentation often leads to ...
Elizabeth Dennis Nkanga +7 more
doaj +1 more source
Expression of MMP-14 and CD44 associated with proliferation of retinoblastoma cells
Medicine Science, 2019 Retinoblastoma is a the most common primary intraocular malignant tumor in childhood. The eexpressions of CD44 and MMP-14 and Their role in proliferation and migration cells appear crucial for retinoblastoma invasion.
Hendrian D. Soebagjo +4 more
doaj +1 more source
Nitric oxide suppression by secreted frizzled-related protein 2 drives retinoblastoma
Cell Reports, 2023 Summary: Retinoblastoma is a cancer of the infant retina primarily driven by loss of the Rb tumor suppressor gene, which is undruggable. Here, we report an autocrine signaling, mediated by secreted frizzled-related protein 2 (SFRP2), which suppresses ...
Panneerselvam Jayabal +10 more
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