Results 41 to 50 of about 151,276 (329)

Longer Lag Time in Early-Stage Retinoblastoma

Folia Medica Indonesiana, 2022
Highlights: • Patients with IRSS I stage have the longest lag time than IVB stage. • Lag time is no significant with stage retinoblastoma.   Abstract: Retinoblastoma is a rare neoplasm disease that occurs in children, generally under the age of ...
Anindya Citra, Budi Utomo, Hendrian Dwikoloso Soebagjo   +2 more
doaj   +1 more source

Phosphorylation of pRb: mechanism for RB pathway inactivation in MYCN-amplified retinoblastoma. [PDF]

, 2017
A small, but unique subgroup of retinoblastoma has been identified with no detectable mutation in the retinoblastoma gene (RB1) and with high levels of MYCN gene amplification.
Bhatti, Tricia R., Eagle Jr., Ralph C., Ewens, Kathryn G., Ganguly, Arupa, Moran, Kimberly A., Richards-Yutz, Jennifer, Shields, Carol L.   +6 more
core   +2 more sources

Cell‐free DNA profiling in retinoblastoma patients with advanced intraocular disease: An MSKCC experience

Cancer Medicine, 2020
The enucleation rate for retinoblastoma has dropped from over 95% to under 10% in the past 10 years as a result of improvements in therapy. This reduces access to tumor tissue for molecular profiling, especially in unilateral retinoblastoma, and hinders ...
Prachi Kothari, F. Marass, Julie L. Yang, Caitlin M. Stewart, Dennis Stephens, J. Patel, Maysun Hasan, Xiaohong Jing, Fanli Meng, J. Enriquez, K. Huberman, A. Viale, J. Francis, M. Berger, N. Shukla, D. Abramson, I. Dunkel, D. Tsui   +17 more
semanticscholar   +1 more source

Mutations in the RB1 Gene in Argentine Retinoblastoma Patients and Uncommon Clinical Presentations [PDF]

, 2015
Background: Retinoblastoma, the most common ocular cancer of childhood, is caused by inactivation of the RB1 tumor suppressor gene in the developing retina.
Alonso, Cristina, Ferrer, Marcela Maria, Giliberto, Florencia, Luce, Leonela Natalia, Ottaviani, Daniela, Parma, Diana Lidia, Szijan, Irena   +6 more
core   +1 more source

Retinoblastoma in Late Childhood

Journal of Nepal Medical Association, 2003
Retinoblastoma, the commonest intra-ocular tumor of childhood, is rare after the age of 5 years. We report a case of retinoblastoma in a 10 year-old boy, who presented with a fungating proptosed tender mass involving the entire left eye and the orbit.
B Badhu, S P Sah, S Kumar, R P Sah
doaj   +1 more source

Analysis of MDM2 and MDM4 single nucleotide polymorphisms, mRNA splicing and protein expression in retinoblastoma. [PDF]

PLoS ONE, 2012
Retinoblastoma is a childhood cancer of the developing retina that begins in utero and is diagnosed in the first years of life. Biallelic RB1 gene inactivation is the initiating genetic lesion in retinoblastoma.
Justina McEvoy, Anatoly Ulyanov, Rachel Brennan, Gang Wu, Stanley Pounds, Jinghui Zhang, Michael A Dyer   +6 more
doaj   +1 more source

Retinoblastoma: A review of the molecular basis of tumor development and its clinical correlation in shaping future targeted treatment strategies

Indian Journal of Ophthalmology, 2023
Retinoblastoma is a retinal cancer that affects children and is the most prevalent intraocular tumor worldwide. Despite tremendous breakthroughs in our understanding of the fundamental mechanisms that regulate progression of retinoblastoma, the ...
Shruti Rathore, Aman Verma, Ria Ratna, Navjot Marwa, Yagya Ghiya, Santosh G Honavar, Anil Tiwari, Sima Das, Akhil Varshney   +8 more
doaj   +1 more source

miR-214-3p Regulates Multi-Drug Resistance and Apoptosis in Retinoblastoma Cells by Targeting ABCB1 and XIAP

OncoTargets and Therapy, 2020
Background MicroRNAs (miRNAs) have been shown to contribute to the initiation and progression of human cancer, including retinoblastoma. However, expression levels and potential roles of miRNAs in retinoblastoma remain largely unknown.
Lidong Yang, Liyou Zhang, Lu Lu, Yan Wang   +3 more
semanticscholar   +1 more source

The retinoblastoma tumor suppressor modulates DNA repair and radioresponsiveness. [PDF]

, 2014
PURPOSE: Perturbations in the retinoblastoma pathway are over-represented in advanced prostate cancer; retinoblastoma loss promotes bypass of first-line hormone therapy.
Addya, Sankar, Birbe, Ruth, Boopathi, Ettickan, Ciment, Steve, Den, Robert, MD, Dicker, Adam, MD, PhD, Ertel, Adam, Fortina, Paolo, Knudsen, Karen E, Liu, Yi, McMahon, Steve B, Mellert, Hestia, O\u27Neill, Raymond, Sharma, Ankur, Thangavel, Chellappagounder   +14 more
core   +1 more source

Molecular analysis distinguishes metastatic disease from second cancers in patients with retinoblastoma [PDF]

, 2016
The pediatric ocular tumor retinoblastoma readily metastasizes, but these lesions can masquerade as histologically similar pediatric small round blue cell tumors.
Argiropoulos, Bob, Chan, Helen S. L., Corson, Timothy W., Gallie, Brenda L., MacDonald, Heather, Matevski, Donco, Perrier, Renée, Piovesan, Beata, Racher, Hilary, Rushlow, Diane, Shaikh, Furqan, Soliman, Sameh   +11 more
core   +1 more source