Results 231 to 240 of about 88,526 (282)

Retinoblastoma protein meets chromatin

Trends in Biochemical Sciences, 1999
The retinoblastoma (RB) protein exerts its tumour-suppressor function by repressing the transcription of cellular genes required for DNA replication and cell division. Recent investigations into the mechanism of RB repression have revealed that RB can regulate transcription by effecting changes in chromatin structure.
A, Brehm, T, Kouzarides
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Retinoblastoma proteins in plants

Plant Molecular Biology, 1999
The retinoblastoma protein Rb is part of a conserved pathway that controls the activation of cell division in animals. Rb represses cell cycle transcription factors of the E2F family, and thereby prevents uncontrolled cell proliferation. Rb itself is inactivated when phosphorylated by cyclin-dependent kinases, and the D-type cyclin kinases are ...
S M, de Jager, J A, Murray
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The Family of Retinoblastoma Proteins

Critical Reviews™ in Eukaryotic Gene Expression, 2001
Our understanding of how the retinoblastoma family members, pRB/p105, pRB2/p130, and pRBL1/p107, regulate cellular properties has progressed significantly. Mechanisms have been described regarding how these proteins utilize properties of additional factors, such as histone deacetylases, to negatively regulate transcription.
Stiegler P., Giordano A.
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Retinoblastoma protein partners

2001
Studies of the retinoblastoma gene (Rb) have shown that its protein product (pRb) acts to restrict cell proliferation, inhibit apoptosis, and promote cell differentiation. The frequent mutation of the Rb gene, and the functional inactivation of pRb in tumor cells, have spurred interest in the mechanism of pRb action.
E J, Morris, N J, Dyson
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Retinoblastoma protein in microphthalmic mice

Experimental and Toxicologic Pathology, 2000
A microphthalmic strain of mice was used to study immunoresponse of the retinoblastoma protein. Comparing wild-type, heterozygote and homozygote microphthalmic eyes, we found an increasing labelling of phosphorylated retinoblastoma protein (pRb) in the retinal pigment epithelium.
J, Richter, E, Brylla, C, Lenk, J, Ernstberger, H, Hilbig   +4 more
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Transcriptional inhibition by the retinoblastoma protein

Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences, 1993
The retinoblastoma protein, pRB, appears to play a key role in coordinating the regulation of cell cycle position and transcriptional events. pRB undergoes specific cell-cycle-dependent phosphorylation, being underphosphorylated in G1 and heavily phosphorylated in S, G2, and M. The underphosphorylated form is able to interact with the E2F transcription
Fattaey, A, Helin, K, Harlow, E
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Molecular dynamics simulations of retinoblastoma protein

Journal of Biomolecular Structure and Dynamics, 2013
Tumor suppressor proteins play a crucial role in cell cycle regulation. Retinoblastoma protein (pRB) is one among them which regulates G1-S transition by binding with transcription factors. The activity of pRB is deregulated by cyclin dependent kinases-mediated hyper-phosphorylation and also due to cancer-derived mutations.
C, Ramakrishnan, V, Subramanian, K, Balamurugan, D, Velmurugan   +3 more
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Corepressors and Retinoblastoma Protein Function

2001
The retinoblastoma protein (Rb) is a ubiquitous transcriptional repressor and a negative regulator of the Gl-to-S phase transition in the eukaryotic cell cycle. Through this inhibitory activity, Rb plays a critical role in suppressing neoplastic transformation and is disrupted in most cancers, either by mutation of the Rb gene (Lee et al. 1988; Shew et
J W, Harbour, D C, Dean
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The retinoblastoma tumor suppressor protein

Current Opinion in Genetics & Development, 1995
Loss of the retinoblastoma protein, pRb, appears to have a role in several human tumor types. Mice lacking pRb have been produced as models of human disease, but have a different spectrum of affected tissues. Recent work shows that the tumorigenic effects of pRb may be revealed only after additional genetic alterations, such as loss of p53. New targets/
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Functions of the retinoblastoma protein

BioEssays, 1999
The retinoblastoma protein (pRB) can both positively and negatively regulate transcription. The former correlates with its ability to promote differentiation and the latter with its ability to regulate entry into S-phase. pRB negatively regulates transcription by forming complexes with members of the E2F transcription factor family.
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