Results 251 to 260 of about 2,616,742 (302)
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Retinoic acid and retinoic acid receptors in craniofacial development
Seminars in Cell & Developmental Biology, 1997Interest in retinoids and craniofacial development originated independently from nutritional and teratological studies; however, the site of action of retinoids in normal development remains contentious. Recent transgenic strategies have shown that retinoic acid and nuclear retinoid receptors are required for the morphogenetic specification of cranial ...
P, Brickell, P, Thorogood
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The American Journal of Clinical Nutrition, 1979
Retinoic acid (RA) is now considered anormal metabolite of vitamin A. It has been established that RA maintains health and supports growth in animals but differs from other forms of vitamin A in that RA does not function in visual or reproductive processes.
D B, Ott, P A, Lachance
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Retinoic acid (RA) is now considered anormal metabolite of vitamin A. It has been established that RA maintains health and supports growth in animals but differs from other forms of vitamin A in that RA does not function in visual or reproductive processes.
D B, Ott, P A, Lachance
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Evolution of Retinoic Acid Receptors and Retinoic Acid Signaling
2014Retinoic acid (RA) is a vitamin A-derived morphogen controlling important developmental processes in vertebrates, and more generally in chordates, including axial patterning and tissue formation and differentiation. In the embryo, endogenous RA levels are controlled by RA synthesizing and degrading enzymes and the RA signal is transduced by two ...
Gutierrez-Mazariegos, Juliana +2 more
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New England Journal of Medicine, 1985
Retinoic acid, an analogue of vitamin A, is known to be teratogenic in laboratory animals and has recently been implicated in a few clinical case reports. To study the human teratogenicity of this agent, we investigated 154 human pregnancies with fetal exposure to isotretinoin, a retinoid prescribed for severe recalcitrant cystic acne.
Edward J. Lammer +11 more
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Retinoic acid, an analogue of vitamin A, is known to be teratogenic in laboratory animals and has recently been implicated in a few clinical case reports. To study the human teratogenicity of this agent, we investigated 154 human pregnancies with fetal exposure to isotretinoin, a retinoid prescribed for severe recalcitrant cystic acne.
Edward J. Lammer +11 more
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2007
Retinoic acid (RA), the active derivative of vitamin A, by acting through retinoid receptors, is involved in signal transduction pathways regulating embryonic development, tissue homeostasis, and cellular differentiation and proliferation. RA is important for the development of the heart.
Jing, Pan, Kenneth M, Baker
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Retinoic acid (RA), the active derivative of vitamin A, by acting through retinoid receptors, is involved in signal transduction pathways regulating embryonic development, tissue homeostasis, and cellular differentiation and proliferation. RA is important for the development of the heart.
Jing, Pan, Kenneth M, Baker
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Journal of the American Academy of Dermatology, 2001
The tissue distribution of retinoic acid (RA) throughout development is highly restricted, defined by the expression patterns of enzymes involved in RA synthesis and catabolism. Presented is a summary of recent research that examines the role of some of the enzymes involved in RA distribution, particularly those involved in RA catabolism (P450RAI ...
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The tissue distribution of retinoic acid (RA) throughout development is highly restricted, defined by the expression patterns of enzymes involved in RA synthesis and catabolism. Presented is a summary of recent research that examines the role of some of the enzymes involved in RA distribution, particularly those involved in RA catabolism (P450RAI ...
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History of Retinoic Acid Receptors
2014The discovery of retinoic acid receptors arose from research into how vitamins are essential for life. Early studies indicated that Vitamin A was metabolized into an active factor, retinoic acid (RA), which regulates RNA and protein expression in cells.
Benbrook, Doris M. +3 more
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Australasian Journal of Dermatology, 1972
SUMMARY This study was undertaken to ascertain whether Retinoic Acid is of clinical use in the treatment of psoriasis and further, to compare its efficacy with an acknowledged successful method of treatment, i.e. the modified Leeds regime.
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SUMMARY This study was undertaken to ascertain whether Retinoic Acid is of clinical use in the treatment of psoriasis and further, to compare its efficacy with an acknowledged successful method of treatment, i.e. the modified Leeds regime.
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Retinoic Acid and Retinoic Acid Receptors as Pleiotropic Modulators of the Immune System
Annual Review of Immunology, 2016Vitamin A is a multifunctional vitamin implicated in a wide range of biological processes. Its control over the immune system and functions are perhaps the most pleiotropic not only for development but also for the functional fate of almost every cell involved in protective or regulatory adaptive or innate immunity.
Alexandre, Larange, Hilde, Cheroutre
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Modulation of limb bud chondrogenesis by retinoic acid and retinoic acid receptors
The International Journal of Developmental Biology, 1995An excess of retinoic acid (RA) in the mouse embryo in utero produces hypochondrogenesis and severe limb bone deformities. Since one of the RA receptors--RAR-beta 2, is specifically induced in the limb bud cells upon treatment of embryos with teratogenic doses of RA, we investigated if this receptor played a role in teratogenesis by regulating the ...
H, Jiang +6 more
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