Results 271 to 280 of about 5,117,644 (334)

Type I interferon signalling and interferon‐responsive microglia in health and disease

The FEBS Journal, EarlyView.
Recent insights reveal that type I interferon (IFN‐I) signalling plays critical roles in the nervous system beyond antiviral defence. Dysregulated IFN‐I activity is increasingly linked to neurological dysfunction and neurodegeneration, with microglia as central mediators. This review explores the broader impact of IFN‐I signalling on the nervous system
Jose P. Lopez‐Atalaya, Aysha M. Bhojwani‐Cabrera   +1 more
wiley   +1 more source

EZH2 inhibition sensitizes retinoic acid-driven senescence in synovial sarcoma. [PDF]

Cell Death Dis
Mushtaq M, Liaño-Pons J, Wang J, Alzrigat M, Yuan Y, Ruiz-Pérez MV, Chen Y, Kashuba E, Haglund de Flon F, Brodin B, Arsenian-Henriksson M.   +10 more
europepmc   +1 more source

Potential cytotoxicity of truncated slow skeletal muscle troponin T (ssTnT) in a loss of function TNNT1 myopathy mouse model

The FEBS Journal, EarlyView.
A loss of function TNNT1 myopathy mouse model with the nonsense mutation p.E180* showed potential cytotoxicity of the truncated slow troponin T fragment. The mRNA expression profile in the soleus muscle of Tnnt1‐p.E180* mice showed very different changes in comparison to that of Tnnt1‐knockout mice.
Han‐Zhong Feng, Kevin A. Strauss, Jian‐Ping Jin   +2 more
wiley   +1 more source

Modifications of Cytochrome <i>c</i> by Retinoic Acid Play a Crucial Role in Mitochondrial Dysfunction of Triple-Positive Human Breast Cancer Cells: Raman Spectroscopy and Imaging Study. [PDF]

ACS Omega
Abramczyk H, Kopeć M, Surmacki J.
europepmc   +1 more source

Associations of serum carotenoids with cardiovascular disease mortality among patients with metabolic dysfunction‐associated steatotic liver disease

Hepatology Research, EarlyView.
In metabolic dysfunction‐associated steatotic liver disease/metabolic dysfunction‐associated steatohepatitis patients aged <60 years, high serum β‐cryptoxanthin concentrations were inversely associated with CVD mortality. Abstract Aim High cardiovascular disease (CVD) mortality occurred among metabolic dysfunction‐associated steatotic liver disease ...
Qian‐Qian Wang, Jing Zhu, Lin‐Jun Miao, Si‐Ang Lv, Guo‐Yin Shen, Jun Wu   +5 more
wiley   +1 more source

Predictive modelling of acute Promyelocytic leukaemia resistance to retinoic acid therapy. [PDF]

Brief Bioinform
Sánchez-Villanueva JA, N'Guyen L, Poplineau M, Duprez E, Remy É, Thieffry D.   +5 more
europepmc   +1 more source

Common Hematologic Emergencies—Acute Promyelocytic Leukemia and Microangiopathic Hemolytic Anemias—A Pivotal Role of Clinical Laboratory

International Journal of Laboratory Hematology, EarlyView.
ABSTRACT Hematologic emergencies are urgent health conditions which result in significant mortality and morbidity unless timely therapeutic measures are taken. Therapeutic success depends on their timely and accurate recognition by hematology laboratory services.
Ganna Shestakova, Nicolas Ulrich Edgar, Anton V. Rets   +2 more
wiley   +1 more source

Retinoic acid receptor-β deletion in a model of early pancreatic ductal adenocarcinoma (PDAC) tumorigenesis. [PDF]

Am J Cancer Res
Mere Del Aguila E, Tang XH, Gudas LJ.
europepmc   +1 more source

Neurotrophic extracellular matrix proteins promote neuronal and iPSC astrocyte progenitor cell‐ and nano‐scale process extension for neural repair applications

Journal of Anatomy, Volume 246, Issue 4, Page 585-601, April 2025.
The extracellular matrix plays a critical role in modulating cell behaviour in the central nervous system influencing neural cell morphology and growth. However, a better understanding of the impact of individual matrix proteins on both neurons and astrocytes is critical for advancing the development of matrix‐based neural repair strategies.
Cian O'Connor, Rena E. Mullally, Sarah F. McComish, Julia O'Sullivan, Ian Woods, Ingmar Schoen, Massimiliano Garre, Maeve A. Caldwell, Adrian Dervan, Fergal J. O'Brien   +9 more
wiley   +1 more source

Long-term Persistence of Dysplastic Features in Patients with Acute Promyelocytic Leukemia Treated with All-trans Retinoic Acid and Arsenic Trioxide. [PDF]

Mediterr J Hematol Infect Dis
Santinelli E, Pascale MR, Guarnera L, Savi A, Mallegni F, Catanoso ML, Gurnari C, Maurillo L, Voso MT, Fenu S.   +9 more
europepmc   +1 more source