Results 291 to 300 of about 146,563 (345)
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Pathobiology, 1992
Abstract The establishment of anatomical structures of the embryo throughout its development is thought to be controlled by morphogenctic molecules, which would instruct the cells of the three germ layers to differentiate according to their position with respect to organizing region(s) (Slack 1987a; Wolpert 1989; Summerbell and Maden ...
Pierre Leroy +5 more
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Abstract The establishment of anatomical structures of the embryo throughout its development is thought to be controlled by morphogenctic molecules, which would instruct the cells of the three germ layers to differentiate according to their position with respect to organizing region(s) (Slack 1987a; Wolpert 1989; Summerbell and Maden ...
Pierre Leroy +5 more
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Retinoic acid and retinoic acid receptors in development
Molecular Neurobiology, 1995The vitamin A derivative retinoic acid (RA) and related compounds (retinoids) are utilized as signaling molecules in a diverse array of developmental and physiological regulatory processes, including many important in the developing and mature nervous system. Retinoids function by interaction with high affinity receptors of the nuclear receptor family,
H M, Sucov, R M, Evans
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Retinoic acid and retinoic acid receptors in craniofacial development
Seminars in Cell & Developmental Biology, 1997Interest in retinoids and craniofacial development originated independently from nutritional and teratological studies; however, the site of action of retinoids in normal development remains contentious. Recent transgenic strategies have shown that retinoic acid and nuclear retinoid receptors are required for the morphogenetic specification of cranial ...
P, Brickell, P, Thorogood
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Altered retinoic acid receptors
The FASEB Journal, 1996Structurally and functionally altered retinoic acid receptors have been associated with rare human neoplasms: acute promyelocytic leukemia and hepatocellular carcinoma. Whereas the ret‐ inoic acid receptor β (RARβ) rearrangement in hepatocellular carcinoma is unique, in acute promyelocytic leukemia (APL), RARα fusion to the ...
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Evolution of Retinoic Acid Receptors and Retinoic Acid Signaling
2014Retinoic acid (RA) is a vitamin A-derived morphogen controlling important developmental processes in vertebrates, and more generally in chordates, including axial patterning and tissue formation and differentiation. In the embryo, endogenous RA levels are controlled by RA synthesizing and degrading enzymes and the RA signal is transduced by two ...
Gutierrez-Mazariegos, Juliana +2 more
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Retinoic acid receptors at 35 years
Journal of Molecular Endocrinology, 2022For almost a century, vitamin A has been known as a nutrient critical for normal development, differentiation, and homeostasis; accordingly, there has been much interest in understanding its mechanism of action. This review is about the discovery of specific receptors for the vitamin A derivative, retinoic acid (RA), which launched extensive molecular,
Martin Petkovich, Pierre Chambon
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RETINOIC ACID RECEPTORS AND CANCERS
Annual Review of Nutrition, 2004▪ Abstract Studies utilizing experimental animals, epidemiological approaches, cellular models, and clinical trials all provide evidence that retinoic acid and some of its synthetic derivatives (retinoids) are useful pharmacological agents in cancer therapy and prevention.
Dianne Robert, Soprano +2 more
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2010
Retinoids, a group of structural and functional derivatives of vitamin A are known to regulate a large number of essential biological processes such as cell growth, differentiation and death. The retinoic acid (RA) signalling pathway involves the precise regulation of retinoid levels and the control of RA-dependent gene expression in target cells.
Audrey Cras +2 more
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Retinoids, a group of structural and functional derivatives of vitamin A are known to regulate a large number of essential biological processes such as cell growth, differentiation and death. The retinoic acid (RA) signalling pathway involves the precise regulation of retinoid levels and the control of RA-dependent gene expression in target cells.
Audrey Cras +2 more
openaire +1 more source
History of Retinoic Acid Receptors
2014The discovery of retinoic acid receptors arose from research into how vitamins are essential for life. Early studies indicated that Vitamin A was metabolized into an active factor, retinoic acid (RA), which regulates RNA and protein expression in cells.
Doris M, Benbrook +3 more
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