Results 291 to 300 of about 357,868 (360)

Cancer treatment and survivorship statistics, 2025

CA: A Cancer Journal for Clinicians, Volume 75, Issue 4, Page 308-340, July/August 2025.
Abstract The number of people living with a history of cancer in the United States continues to rise because of the growth and aging of the population as well as improved survival through advances in early detection and treatment. To assist the public health community serve the needs of these survivors, the American Cancer Society and the National ...
Nikita Sandeep Wagle, Leticia Nogueira, Theresa P. Devasia, Angela B. Mariotto, K. Robin Yabroff, Farhad Islami, Ahmedin Jemal, Rick Alteri, Patricia A. Ganz, Rebecca L. Siegel   +9 more
wiley   +1 more source

Mitochondrial DNA affects tau phosphorylation in aging and Alzheimer's disease

Alzheimer's &Dementia, Volume 21, Issue 7, July 2025.
Abstract INTRODUCTION Impaired mitochondrial function is seen in Alzheimer's disease (AD), but its role is unclear. Mitochondrial DNA (mtDNA) supports bioenergetic metabolism, but it is uncertain how it might influence AD neuropathology. METHODS We used cytoplasmic hybrid (cybrid) cell lines made from SH‐SY5Y cells expressing mtDNA from cognitively ...
Riley E. Kemna, Paul J. Kueck, Robyn Honea, Zachary Clark, Michaella Rekowski, Ian Weidling, Hana Mayfield, Casey S. John, Jeffrey Burns, Heather M. Wilkins, Russell Swerdlow, Jill K. Morris   +11 more
wiley   +1 more source

Comprehensive characterization of the RNA editing landscape in the human aging brains with Alzheimer's disease

Alzheimer's &Dementia, Volume 21, Issue 7, July 2025.
Abstract INTRODUCTION While RNA editing has been linked to Alzheimer's disease (AD), its specific impact on the transcriptomic landscape in human AD brains remains under explored. METHODS We conducted a comprehensive analysis of RNA editing across nine human brain regions affected by AD, utilizing RNA‐seq data and matched whole‐genome sequencing data ...
Amit Kumar Gupta, William Martin, Andrew A. Pieper, Yinsheng Wang, Andrew J. Saykin, Feixiong Cheng   +5 more
wiley   +1 more source

Retinoic acid receptors at 35 years

Journal of Molecular Endocrinology, 2022
For almost a century, vitamin A has been known as a nutrient critical for normal development, differentiation, and homeostasis; accordingly, there has been much interest in understanding its mechanism of action. This review is about the discovery of specific receptors for the vitamin A derivative, retinoic acid (RA), which launched extensive molecular,
Martin Petkovich, Pierre Chambon
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Identification of a receptor for the morphogen retinoic acid

Nature, 1987
Analysis of complementary DNA encoding a novel gene product reveals striking similarity to the steroid and thyroid hormone receptors. Binding and transcription activational studies show it to be a receptor for the vitamin A-related morphogen retinoic acid.
Ronald M. Evans, Vincent Giguère, Prudimar Serrano Segui, Estelita S. Ong   +3 more
openaire   +4 more sources

Identification of a retinoic acid responsive element in the retinoic acid receptor & beta;gene

Nature, 1990
Retinoic acid, the first morphogen described so far in vertebrates, is a vitamin A derivative which exerts striking effects on development and differentiation. The identification of three retinoic acid receptors as members of the nuclear receptor super-family provides an explantation for the molecular action of morphogens on gene expression. Functional
de Thé, Hugues, del Mar Vivanco-Ruiz, Maria, Tiollais, Pierre, Stunnenberg, Henk, Dejean, Anne   +4 more
openaire   +4 more sources

Identification of a second human retinoic acid receptor

Nature, 1988
We have previously described a human complementary DNA that encodes a novel protein which is homologous to members of the steroid/thyroid nuclear receptor multigene family. This novel protein (hap for hepatoma) exhibits strong homology with the human retinoic acid receptor (RAR) which has been recently characterized.
Brand, Nigel, Petkovich, Martin, Krust, Andrée, Chambon, Pierre, de Thé, Hugues, Marchio, Agnès, Tiollais, Pierre, Dejean, Anne   +7 more
openaire   +4 more sources

RETINOIC ACID RECEPTORS AND CANCERS [PDF]

Annual Review of Nutrition, 2004
▪ Abstract  Studies utilizing experimental animals, epidemiological approaches, cellular models, and clinical trials all provide evidence that retinoic acid and some of its synthetic derivatives (retinoids) are useful pharmacological agents in cancer therapy and prevention.
Pu Qin, Dianne Robert Soprano, Kenneth J. Soprano   +2 more
openaire   +2 more sources

Combating Autoimmune Diseases With Retinoic Acid Receptor-Related Orphan Receptor-γ (RORγ or RORc) Inhibitors: Hits and Misses.

Journal of Medicinal Chemistry, 2018
The nuclear receptor retinoic acid receptor-related orphan receptor gamma (RORγ or RORc) is a key transcription factor for the production of pro-inflammatory cytokines implicated in the pathogenesis of autoimmune diseases.
Vrajesh Bhaskarbhai Pandya, Sanjay Kumar, S. Sachchidanand, Rajiv Sharma, R. Desai   +4 more
semanticscholar   +1 more source

Retinoic acid and retinoic acid receptors in development

Molecular Neurobiology, 1995
The vitamin A derivative retinoic acid (RA) and related compounds (retinoids) are utilized as signaling molecules in a diverse array of developmental and physiological regulatory processes, including many important in the developing and mature nervous system. Retinoids function by interaction with high affinity receptors of the nuclear receptor family,
Ronald M. Evans, Henry M. Sucov
openaire   +3 more sources