Results 301 to 310 of about 357,868 (360)

Nonclinical and human pharmacology of the potent and selective topical retinoic acid receptor‐γ agonist trifarotene

British Journal of Dermatology, 2018
First‐ and third‐generation retinoids are the main treatment for acne. Even though efficacious, they lack full selectivity for retinoic acid receptor (RAR) γ, expressed in the epidermis and infundibulum.
J. Aubert, D. Piwnica, B. Bertino, S. Blanchet-Réthoré, I. Carlavan, S. Deret, B. Dréno, Bastien Gamboa, A. Jomard, A. Luzy, P. Mauvais, C. Mounier, J. Pascau, I. Pelisson, T. Portal, M. Rivier, P. Rossio, E. Thoreau, E. Vial, J. Voegel   +19 more
semanticscholar   +1 more source

Retinoic acid and retinoic acid receptors in craniofacial development

Seminars in Cell & Developmental Biology, 1997
Interest in retinoids and craniofacial development originated independently from nutritional and teratological studies; however, the site of action of retinoids in normal development remains contentious. Recent transgenic strategies have shown that retinoic acid and nuclear retinoid receptors are required for the morphogenetic specification of cranial ...
Paul M. Brickell, Peter Thorogood
openaire   +3 more sources

The Retinoic Acid Receptors [PDF]

, 2015
Three retinoic acid receptors (RAR), structurally homologous to steroid and thyroid hormone nuclear receptors, have recently been cloned. Analysis of the tissue distribution of RARs mRNAs have demonstrated a distinct expression pattern of the receptors' transcripts. Moreover, the RAR beta gene specifically, is autoregulated by RA.
Hugues de Th�, Anne Dejean
openaire   +1 more source

Modulators of the nuclear receptor retinoic acid receptor-related orphan receptor-γ (RORγ or RORc).

Journal of Medicinal Chemistry, 2014
As the biology surrounding the nuclear receptor retinoic acid receptor-related orphan receptor-gamma (RORγ or RORc) continues to evolve, significant effort has been invested in discovering modulators of this potentially important target for the treatment
Ben Fauber, Steven Magnuson
semanticscholar   +1 more source

Evolution of Retinoic Acid Receptors and Retinoic Acid Signaling

2014
Retinoic acid (RA) is a vitamin A-derived morphogen controlling important developmental processes in vertebrates, and more generally in chordates, including axial patterning and tissue formation and differentiation. In the embryo, endogenous RA levels are controlled by RA synthesizing and degrading enzymes and the RA signal is transduced by two ...
Gutierrez-Mazariegos, Juliana, Schubert, Michael, Laudet, Vincent   +2 more
openaire   +4 more sources

History of Retinoic Acid Receptors

2014
The discovery of retinoic acid receptors arose from research into how vitamins are essential for life. Early studies indicated that Vitamin A was metabolized into an active factor, retinoic acid (RA), which regulates RNA and protein expression in cells.
Cécile Rochette-Egly, Pierre Chambon, Doris M. Benbrook, Mary Ann Asson-Batres   +3 more
openaire   +2 more sources

Retinoic Acid Receptors in Hematopoiesis

1996
Retinoic acid receptors (RARs) are critical transcriptional regulators that are involved in the development and differentiation of a wide variety of different cells (Evans 1988). Several lines of evidence suggest that RARs may be involved in the regulation of hematopoiesis.
Irwin D. Bernstein, Schickwann Tsai, Steven J. Collins   +2 more
openaire   +3 more sources

Developmental roles of the retinoic acid receptors

The Journal of Steroid Biochemistry and Molecular Biology, 1995
Retinoic acid, one of the principle active metabolites of vitamin A (retinol), is believed to be essential for numerous developmental and physiological processes. Vitamin A deprivation (VAD) during development leads to numerous congenital defects. Previous studies of retinoic acid receptor (RAR) deficient mice failed to reveal any of these VAD-induced ...
Lohnes, David, Mark, Manuel, Mendelsohn, Cathy, Dollé, Pascal, Decimo, Didier, Lemeur, Marianne, Dierich, Andrée, Gorry, Philippe, Chambon, Pierre   +8 more
openaire   +5 more sources

Retinoic Acid and Retinoic Acid Receptors as Pleiotropic Modulators of the Immune System

Annual Review of Immunology, 2016
Vitamin A is a multifunctional vitamin implicated in a wide range of biological processes. Its control over the immune system and functions are perhaps the most pleiotropic not only for development but also for the functional fate of almost every cell involved in protective or regulatory adaptive or innate immunity.
Hilde Cheroutre, Alexandre Larange
openaire   +2 more sources

Chronicle of a discovery: the retinoic acid receptor

Journal of Molecular Endocrinology, 2022
The landmark 1987 discovery of the retinoic acid receptor (RAR) came as a surprise, uncovering a genomic kinship between the fields of vitamin A biology and steroid receptors. This stunning breakthrough triggered a cascade of studies to deconstruct the roles played by the RAR and its natural and synthetic ligands in embryonic development, skin, growth,
Vincent Giguère, Ronald M Evans
openaire   +2 more sources