Results 151 to 160 of about 390,951 (380)

Hallmarks of Neuroblastoma—Pathophysiology, Diagnosis, and Therapeutic Interventions

Cancer Nexus, EarlyView.
ABSTRACT Neuroblastoma, the most common extracranial solid tumor in childhood, continues to challenge clinicians and researchers because of its heterogeneous nature and complex pathophysiology. Recent breakthroughs in molecular profiling revealed intricate genetic alterations driving tumor progression, necessitating an updated perspective on the ...
Abhimanyu Thakur, Anne Dijkstra
wiley   +1 more source

Retinoic acid promotes transcription of the platelet-derived growth factor alpha-receptor gene. [PDF]

, 1990
Chao Wang, James D. Kelly, Daniel F. Bowen‐Pope, Charles D. Stiles   +3 more
openalex   +1 more source

Epigenotoxicity: Decoding the epigenetic imprints of genotoxic agents and their implications for regulatory genetic toxicology

Environmental and Molecular Mutagenesis, EarlyView.
Abstract Regulatory genetic toxicology focuses on DNA damage and subsequent gene mutations. However, genotoxic agents can also affect epigenetic marks, and incorporation of epigenetic data into the regulatory framework may thus enhance the accuracy of risk assessment.
Roger Godschalk, Christopher Faulk, Jessica LaRocca, Jan van Benthem, Francesco Marchetti   +4 more
wiley   +1 more source

Characterization and purification of human retinoic acid receptor-γ 1 overexpressed in the baculovirus-insect cell system [PDF]

, 1992
Ambati P. Reddy, J Y Chen, Tim Zacharewski, Hinrich Gronemeyer, John J. Voorhees, Gary J. Fisher   +5 more
openalex   +1 more source

Genetic epilepsies with myoclonic seizures: Mechanisms and syndromes

Epilepsia Open, EarlyView.
Abstract Genetic epilepsy with myoclonic seizures encompasses a heterogeneous spectrum of conditions, ranging from benign and self‐limiting forms to severe, progressive disorders. While their causes are diverse, a significant proportion stems from genetic abnormalities.
Antonietta Coppola, Marica Rubino, Antonella Riva, Pasquale Striano   +3 more
wiley   +1 more source

TULP4, a novel E3 ligase gene, participates in neuronal migration as a candidate in schizophrenia

CNS Neuroscience &Therapeutics, EarlyView., 2023
Mutations identified from four SCZ pedigrees resulted in decreased TULP4 expression. Tulp4 knockdown caused delayed neuron migration in embryonic mice, and impaired cognition and prepulse inhibition in adult mice. These phenotypes may be related to TULP4 through its involvement in the formation of a novel E3 ubiquitin ligases.
Yan Bi, Decheng Ren, Fan Yuan, Zhou Zhang, Daizhan Zhou, Xin Yi, Lei Ji, Keyi Li, Fengping Yang, Xi Wu, Xingwang Li, Yifeng Xu, Yun Liu, Peng Wang, Changqun Cai, Chuanxin Liu, Qian Ma, Lin He, Yi Shi, Guang He   +19 more
wiley   +1 more source

Cytotoxic Effects of Chitosan/Retinoic Acid/Albumin Targeted Nanoparticles Loaded with Doxorubicin on Human Hepatoma Cells

مجله دانشکده پزشکی اصفهان, 2013
Background: Anthracyclines are used to treat different types of cancer including hepatocellular carcinoma. However, they have various side effects such as cardiotoxicity.
Jaleh Varshosaz, Farshid Hassanzadeh, Hojat Sadeghi Aliabadi, Zahra Alimohammad Ghelichkhan   +3 more
doaj  

Nanoplatform‐Enabled Genetic Interventions for Central Nervous System Disorders: Advances in Delivery Strategies and Therapeutic Potential

Advanced Genetics, EarlyView.
This review provides a detailed description of gene mutations and epigenetic mechanisms in central nervous system (CNS) disease, strategies for gene therapy, challenges for CNS gene therapy and gene‐drug nanocarriers. This review also summarizes the applications of nanogenetic therapy platforms in CNS diseases (brain tumors, neurodegenerative diseases,
Fuming Liang, Shizhen Cui, Jing Yang, Zhaohui He, Ling Zhu   +4 more
wiley   +1 more source

Structural basis for DNA recognition and allosteric control of the retinoic acid receptors RAR-RXR. [PDF]

Nucleic Acids Res, 2020
Osz J, McEwen AG, Bourguet M, Przybilla F, Peluso-Iltis C, Poussin-Courmontagne P, Mély Y, Cianférani S, Jeffries CM, Svergun DI, Rochel N.   +10 more
europepmc   +1 more source

Research in Progress [PDF]

, 1988
Updates on research conducted by the Boston University School of ...
Boston University School of Medicine
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