Results 201 to 210 of about 3,042,168 (283)

Distinct Neuropsychiatric Profiles Associated With 17p11.2 Deletions and RAI1 Variants in Smith–Magenis Syndrome

American Journal of Medical Genetics Part A, Volume 200, Issue 10, Page 2320-2330, October 2026.
ABSTRACT Smith–Magenis syndrome (SMS) results from either a recurrent 17p11.2 deletion or pathogenic variants in the retinoic acid induced 1 gene (RAI1). While neurodevelopmental impairment and behavioral dysregulation are well recognized, systematic genotype‐stratified analyses across psychiatric domains remain limited.
Albin Blanc, Christophe Nemos, Céline Bonnet, Mathilde Renaud, Sandra Chapuis, Pauline Boiroux, Marie‐Noëlle Babinet, Caroline Demily   +7 more
wiley   +1 more source

Vitamins as modulators of Deltaretrovirus infection: implications for HTLV-1 and bovine leukemia virus-associated diseases. [PDF]

Arch Microbiol
Akbarin MM, Farjami Z, Álvarez HR.
europepmc   +1 more source

Loss, persistence and reversal of phenotypic traits

Biological Reviews, Volume 101, Issue 5, Page 2119-2133, October 2026.
ABSTRACT The irreversibility of complex trait loss has long been a tenet of evolutionary biology. However, this idea is increasingly at odds with the numerous documented exceptions across the Tree of Life. We synthesise this growing body of evidence across a diverse array of taxa and traits, exploring the evolutionary conditions that enable ...
Giobbe Forni, Giuseppe Fusco, Filippo Nicolini, Heather Bruce, Andrea Luchetti   +4 more
wiley   +1 more source

Cetyl All-<i>Trans</i>-Retinoate as a Lipidic ATRA Prodrug with Enhanced Anticancer and Chemosensitizing Activity. [PDF]

Int J Mol Sci
Moroz P, Muciek K, Świtalska M, Wietrzyk J, Lazar Z, Gliszczyńska A.   +5 more
europepmc   +1 more source

The CRABP2–MDK Signaling Axis Promotes Lung Adenocarcinoma (LUAD) Progression and Highlights Prognostic Biomarkers

Molecular Carcinogenesis, Volume 65, Issue 10, Page 1163-1182, October 2026.
ABSTRACT Lung cancer is the leading cause of cancer‐related mortality worldwide, with LUAD being characterized by high incidence and mortality rates. Despite the use of various treatments, including surgery, chemotherapy, immunotherapy, and molecular targeted therapy, the prognosis in LUAD patients remains unfavorable.
Jingshun Zhang, Cui Zhang, Guopeng Jiang, Xia Liu, Yifan Li, Fuman Wang, Xuefei Sun, Peidao Sun   +7 more
wiley   +1 more source

Retinoic acid alleviates manganese-induced neurotoxicity in SH-SY5Y cells via the Trim28/α-synuclein/H4K91ac epigenetic axis. [PDF]

Front Pharmacol
Ao C, Liu H, Ban R, Huang T, Xiao Y, Chen W, Feng Y, Zhao H, Ban J, Li J.   +9 more
europepmc   +1 more source

The molecular basis of the interactions between synthetic retinoic acid analogues and the retinoic acid receptors. [PDF]

Medchemcomm, 2017
Haffez H, Chisholm DR, Valentine R, Pohl E, Redfern C, Whiting A.   +5 more
europepmc   +1 more source

Ineffectiveness of immune checkpoint inhibitors in prostate cancer: is it just a question of ‘‐mabs’?

The Journal of Pathology, Volume 270, Issue 2, Page 139-162, October 2026.
Abstract Prostate cancer (PCa) is the second most common type of neoplasm, currently treated with a variety of therapeutic agents. Although advances in treatment over the past decade have improved overall survival, patients with advanced PCa eventually progress from hormone‐sensitive PCa to metastatic castration‐resistant PCa.
Giuseppe Schepisi, Irene Torresan, Emilio Francesco Giunta, Sara Bleve, Nicole Brighi, Elisa Tassinari, Sofia Zanuccoli, Maria Concetta Cursano, Cristian Lolli   +8 more
wiley   +1 more source

SIRT1 in Neurodegenerative Diseases: Molecular Mechanisms, Disease Relevance, and Therapeutic Potential

The FASEB Journal, Volume 40, Issue 17, 15 September 2026.
SIRT1, an NAD+‐dependent deacetylase, supports cognitive resilience by coordinating neuroprotection, synaptic plasticity, autophagy–lysosomal proteostasis, and mitochondrial energy homeostasis. Reduced or dysregulated SIRT1 is associated with protein aggregation, neuroinflammation, mitochondrial dysfunction, synaptic loss, and cognitive decline in ...
Jiabin Duan, Jiaqi Liu, Qingsheng Meng, Jiahao Liu, Sitian Yang, Fang Zhou, Jing Cao   +6 more
wiley   +1 more source

Impaired retinoic acid receptor-γ signaling underlies a heritable form of urothelial keratinizing squamous metaplasia. [PDF]

HGG Adv
Fukushima K, Avery N, Desjardins J, Halliday BJ, Jenkins ZA, Porteous R, Morgan T, Parthasarathy P, Lau M, Vincent MW, Liu KJ, Twigg SRF, Robertson SP.   +12 more
europepmc   +1 more source