Results 261 to 270 of about 390,951 (380)

Transformation of hematopoietic cells by the Ski oncoprotein involves repression of retinoic acid receptor signaling

, 1998
Richard Dahl, Matthias Kieslinger, Hartmut Beug, Michael J. Hayman   +3 more
openalex   +1 more source

Retinoic acid modulates retinoid X receptor α and retinoic acid receptor α levels of cultured brown adipocytes [PDF]

, 1997
M. Luisa Bonet, Pere Puigserver, Francisca Serra, Joan Ribot, Francisca Vázquez, Catalina Picó, Andreu Palou   +6 more
openalex   +1 more source

Lactate Promotes the Second Cell Fate Decision in Blastocysts by Prompting Primitive Endoderm Formation Through an Intercellular Positive Feedback Loop That Couples Paracrine FGF Signalling

Cell Proliferation, EarlyView.
Paracrine FGF4 from EPI precursor cells promotes lactate synthesis within PrE precursor cells, while the increased lactate in turn stimulates FGF‐ERK signalling via lactate shuttling. The increased lactate in PrE precursor cells directly promotes PrE formation by elevating the level of histone lactylation. ABSTRACT Lactate has been widely recognised as
Xiao Hu, Yawen Tang, Wei Zhao, Juan Liu, Zhize Liu, Qianyin Yang, Meiqiang Chu, Jianhui Tian, Lei An, Shumin Wang   +9 more
wiley   +1 more source

Novel immunotherapy for multiple myeloma involving activation of plasmacytoid dendritic cells. [PDF]

Mol Ther Oncol
Kurimoto M, Watanabe T, Kudo M.
europepmc   +1 more source

Sensitization of Non‐M3 Acute Myeloid Leukemia Blasts to All‐Trans Retinoic Acid by the LSD1 Inhibitor Tranylcypromine: TRANSATRA Phase I Study

European Journal of Haematology, EarlyView.
ABSTRACT The treatment of elderly, nonfit acute myeloid leukemia (AML)/MDS patients with relapsed/refractory (R/R) disease remains challenging. As histone demethylase LSD1 (KDM1A) is a rational therapeutic target in AML, we conducted a phase I trial (“rolling‐six design”) with the LSD1 inhibitor tranylcypromine (TCP, dose levels [DL] 20, 40, 60, 80 mg ...
Michael Kruszewski, Claudia Schmoor, Tobias Berg, Usama‐Ur Rehman, Marcus Schittenhelm, Katharina Götze, Andrea Kündgen, Caroline Pabst, Tobias Ma, Anna Frey, Julia Stomper, Dietmar Pfeifer, Eric Metzger, Johannes Jung, Kevin Moschallski, Johanna Thomas, Gesine Bug, Justus Duyster, Manfred Jung, Roland Schüle, Ralph Wäsch, Olga Grishina, Michael Lübbert   +22 more
wiley   +1 more source

Vitamin D and Retinoic Acid Require Protein Kinase C Activity and Reactive Oxygen Species as Opposing Signals Regulating <i>PEIG-1</i>/<i>GPRC5A</i> Expression in Caco-2 and T84 Colon Carcinoma Cells. [PDF]

Biomolecules
Iglesias González PA, Mori C, Valdivieso ÁG, Santa Coloma TA.   +3 more
europepmc   +1 more source

A novel PML germline variant as a candidate predisposing genetic aberration in familial acute myeloid leukaemia

British Journal of Haematology, EarlyView.
Thierry Soussi, Snehangshu Kundu, Pauline Gerbaud, Tatjana Pandzic, Berivan Baskin, Claes Ladenvall, François Delhommeau, Tobias Sjöblom, Panagiotis Baliakas   +8 more
wiley   +1 more source

The CRISPR‐Cas9 knockout DDC SH‐SY5Y in vitro model for AADC deficiency provides insight into the pathogenicity of R347Q and L353P variants: a cross‐sectional structural and functional analysis

The FEBS Journal, EarlyView.
Here, we generated a DDC‐KO cellular model for studying aromatic amino acid decarboxylase (AADC) deficiency. This model was created using CRISPR‐Cas9 in the SH‐SY5Y neuroblastoma cell line and was validated through the absence of the dopamine product and an altered l‐dopa metabolite profile.
Cristian Andres Carmona‐Carmona, Giovanni Bisello, Rossella Franchini, Gianluigi Lunardi, Roberta Galavotti, Massimiliano Perduca, Rui P. Ribeiro, Benny Danilo Belviso, Alejandro Giorgetti, Rocco Caliandro, Patricia M.‐J. Lievens, Mariarita Bertoldi   +11 more
wiley   +1 more source

A Comparative Study of a Potent CNS-Permeable RARβ-Modulator, Ellorarxine, in Neurons, Glia and Microglia Cells In Vitro. [PDF]

Int J Mol Sci
Zhang Y, Gailloud L, Shin A, Fewkes J, Pinckney R, Whiting A, Chazot P.   +6 more
europepmc   +1 more source

Type I interferon signalling and interferon‐responsive microglia in health and disease

The FEBS Journal, EarlyView.
Recent insights reveal that type I interferon (IFN‐I) signalling plays critical roles in the nervous system beyond antiviral defence. Dysregulated IFN‐I activity is increasingly linked to neurological dysfunction and neurodegeneration, with microglia as central mediators. This review explores the broader impact of IFN‐I signalling on the nervous system
Jose P. Lopez‐Atalaya, Aysha M. Bhojwani‐Cabrera   +1 more
wiley   +1 more source