Results 61 to 70 of about 390,951 (380)

TNF receptor–related factor 3 inactivation promotes the development of intrahepatic cholangiocarcinoma through NF‐κB‐inducing kinase–mediated hepatocyte transdifferentiation

Hepatology, EarlyView., 2022
Abstract Background and Aims Intrahepatic cholangiocarcinoma (ICC) is a deadly but poorly understood disease, and its treatment options are very limited. The aim of this study was to identify the molecular drivers of ICC and search for therapeutic targets.
Yuto Shiode, Takahiro Kodama, Satoshi Shigeno, Kazuhiro Murai, Satoshi Tanaka, Justin Y. Newberg, Jumpei Kondo, Shogo Kobayashi, Ryoko Yamada, Hayato Hikita, Ryotaro Sakamori, Hiroshi Suemizu, Tomohide Tatsumi, Hidetoshi Eguchi, Nancy A. Jenkins, Neal G. Copeland, Tetsuo Takehara   +16 more
wiley   +1 more source

Depletion of retinoic acid receptors initiates a novel positive feedback mechanism that promotes teratogenic increases in retinoic acid. [PDF]

PLoS Genetics, 2013
Normal embryonic development and tissue homeostasis require precise levels of retinoic acid (RA) signaling. Despite the importance of appropriate embryonic RA signaling levels, the mechanisms underlying congenital defects due to perturbations of RA ...
Enrico D'Aniello, Ariel B Rydeen, Jane L Anderson, Amrita Mandal, Joshua S Waxman   +4 more
doaj   +1 more source

13-cis retinoic acid exerts its specific activity on human sebocytes through selective intracellular isomerization to all-trans retinoic acid and binding to retinoid acid receptors.

Journal of Investigative Dermatology, 2000
Despite its potent biologic effect on human sebocytes, 13-cis retinoic acid exhibits low binding affinity for cellular retinoic acid binding proteins and nuclear retinoid receptors.
M. Tsukada, Mandy Schröder, C. Orfanos, C. Zouboulis, T. Roos, R. Chandraratna, U. Reichert, H. F. Merk   +7 more
semanticscholar   +1 more source

Bioengineering facets of the tumor microenvironment in 3D tumor models: insights into cellular, biophysical and biochemical interactions

FEBS Open Bio, EarlyView.
The tumor microenvironment is a dynamic, multifaceted complex system of interdependent cellular, biochemical, and biophysical components. Three‐dimensional in vitro models of the tumor microenvironment enable a better understanding of these interactions and their impact on cancer progression and therapeutic resistance.
Salma T. Rafik, Deniz Bakkalci, Alexander J. MacRobert, Umber Cheema   +3 more
wiley   +1 more source

Gut microbiota–derived short‐chain fatty acids regulate group 3 innate lymphoid cells in HCC

Hepatology, EarlyView., 2022
Abstract Background and Aims Type 3 innate lymphoid cells (ILC3s) are essential for host defense against infection and tissue homeostasis. However, their role in the development of HCC has not been adequately confirmed. In this study, we investigated the immunomodulatory role of short‐chain fatty acids (SCFAs) derived from intestinal microbiota in ILC3
Chupeng Hu, Bingqing Xu, Xiaodong Wang, Wen‐Hua Wan, Jinying Lu, Deyuan Kong, Yu Jin, Wenhua You, Hua Sun, Xiaoxin Mu, Dongju Feng, Yun Chen   +11 more
wiley   +1 more source

The role of retinoic acid receptors and their cognate ligands in reproduction in a context of triorganotin based endocrine disrupting chemicals

Endocrine Regulations, 2016
Retinoic acid (RA), an active form of vitamin A, regulates the embryonic development, male and female reproduction and induces important effects on the cell development, proliferation, and differentiation. These effects are mediated by the retinoid (RAR)
Macejova Dana, Toporova L., Brtko J.
doaj   +1 more source

Widespread Alu repeat-driven expansion of consensus DR2 retinoic acid response elements during primate evolution

BMC Genomics, 2007
Background Nuclear receptors are hormone-regulated transcription factors whose signaling controls numerous aspects of development and physiology. Many receptors recognize DNA hormone response elements formed by direct repeats of RGKTCA motifs separated ...
Wang Tian-Tian, Laperriere David, White John H, Mader Sylvie   +3 more
doaj   +1 more source

Retinoids: Mechanisms of Action in Neuronal Cell Fate Acquisition

Life, 2023
Neuronal differentiation has been shown to be directed by retinoid action during embryo development and has been exploited in various in vitro cell differentiation systems.
Aysis Maria Koshy, Marco Antonio Mendoza-Parra   +1 more
doaj   +1 more source

BATF is required for normal expression of gut-homing receptors by T helper cells in response to retinoic acid

Journal of Experimental Medicine, 2013
Induction of gut-homing receptors in T cells in response to retinoic acid requires the transcription factor BATF.
Chuanwu Wang, Shankar Thangamani, Myunghoo Kim, B. Gu, Jeeho Lee, E. Taparowsky, Chang H. Kim   +6 more
semanticscholar   +1 more source

The Genetic Role of Retinoic Acid Receptors in Embryonic Development: Study of Genetic Mutations in Retinoic Acid Receptors, Resulting in Tissue Abnormalities [PDF]

, 2007
Retinoic acid (RA) is a vitamin A derivative that exerts profound influences in vertebrate development and physiology. All-trans RA and 9-cis RA, are important regulators of embryonic development, cellular activity and tissue homeostasis.
Ghaedi, Kamran., Ghasemi, Soraya., Valian Borojeni, Sadegh.   +2 more
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