Results 1 to 10 of about 131,717 (361)

Regulation of retinoid-mediated signaling involved in skin homeostasis by RAR and RXR agonists/antagonists in mouse skin. [PDF]

PLoS ONE, 2013
Endogenous retinoids like all-trans retinoic acid (ATRA) play important roles in skin homeostasis and skin-based immune responses. Moreover, retinoid signaling was found to be dysregulated in various skin diseases.
Janine Gericke, Jan Ittensohn, Johanna Mihály, Susana Alvarez, Rosana Alvarez, Dániel Töröcsik, Angel R de Lera, Ralph Rühl   +7 more
doaj   +7 more sources

Vitamin A Transport Mechanism of the Multitransmembrane Cell-Surface Receptor STRA6 [PDF]

Membranes, 2015
Vitamin A has biological functions as diverse as sensing light for vision, regulating stem cell differentiation, maintaining epithelial integrity, promoting immune competency, regulating learning and memory, and acting as a key developmental morphogen ...
Riki Kawaguchi, Ming Zhong, Miki Kassai, Mariam Ter-Stepanian, Hui Sun   +4 more
doaj   +4 more sources

Aspek Farmakologi Retinoid pada Kosmeseutikal

Jurnal Kesehatan Melayu, 2017
Retinoid merupakan salah satu senyawa aktif yang paling luas penggunaannya di bidang dermatologi, yaitu sebagai anti-akne, anti-aging dan depigmenting agent.
Dina Fauzia
doaj   +4 more sources

Bexarotene signaling in human B and T lymphocytes induces gut-homing receptor expression [PDF]

Frontiers in Immunology
BackgroundRetinoic acid (RA) receptors (RARs) in human lymphocytes modulate the humoral and intestinal immune response by regulating target genes, including CD38, TGM2, and gut-homing markers.
Sina Kaiser, Ina Suhrkamp, Jinru He, Charlotte Helf, Christian D. Sadik, Michael Weichenthal, Guido Heine   +6 more
doaj   +2 more sources

Function annotation of hepatic retinoid x receptor α based on genome-wide DNA binding and transcriptome profiling. [PDF]

, 2012
BackgroundRetinoid x receptor α (RXRα) is abundantly expressed in the liver and is essential for the function of other nuclear receptors. Using chromatin immunoprecipitation sequencing and mRNA profiling data generated from wild type and RXRα-null mouse ...
Fang, Jianwen, Fang, Yaping, He, Yuqi, Liu, Hui-Xin, Wan, Yu-Jui Yvonne, Zhan, Qi   +5 more
core   +9 more sources

Structural and Functional Analysis of Nonheme Iron Enzymes BCMO-1 and BCMO-2 from Caenorhabditis elegans

Frontiers in Molecular Biosciences, 2022
Carotenoid metabolism is critical for diverse physiological processes. The nematode Caenorhabditis elegans has two genes that are annotated as β-carotene 15,15′-monooxygenase (BCMO) and are 17 centimorgan apart on chromosome II, but the function of BCMO ...
Weimin Pan, Yong-Ling Zhou, Jian Wang, Huai-En Dai, Xiao Wang, Xiao Wang, Lin Liu, Lin Liu   +7 more
doaj   +1 more source

Rexinoids Modulate Effector T Cell Expression of Mucosal Homing Markers CCR9 and α4β7 Integrin and Direct Their Migration In Vitro

Frontiers in Immunology, 2022
Altering T cell trafficking to mucosal regions can enhance immune responses towards pathogenic infections and cancers at these sites, leading to better outcomes.
Kavita R. Manhas, Pamela A. Marshall, Carl E. Wagner, Peter W. Jurutka, Michelle V. Mancenido, Hannah Z. Debray, Joseph N. Blattman   +6 more
doaj   +1 more source

Possible Therapeutics for Pseudomyxoma Peritonei: A Rare, Lethal, and the Least Investigated Disease

Journal of Coloproctology, 2023
Pseudomyxoma peritonei (PMP) refers to a growth disorder characterized by glycoprotein neoplasm in the peritoneum, where mucin oversecretion occurs.
Aarifa Nazmeen
doaj   +1 more source

Liposomal delivery of hydrophobic RAMBAs provides good bioavailability and significant enhancement of retinoic acid signalling in neuroblastoma tumour cells [PDF]

, 2020
Retinoid treatment is employed during residual disease treatment in neuroblastoma, where the aim is to induce neural differentiation or death in tumour cells.
Bilip, Maja, Di Florio, Alessia, Eaton, Simon, Hart, Stephen L., Irving, Elsa, Maeshima, Ruhina, Mathiyalakan, Mayuran, Orford, Michael, Shah, Shreya, Simons, Claire, Stoker, Andrew W., Tagalakis, Aristides D.   +11 more
core   +4 more sources

Interphotoreceptor Retinoid-Binding Protein (IRBP) in Retinal Health and Disease

Frontiers in Cellular Neuroscience, 2020
Interphotoreceptor retinoid-binding protein (IRBP), also known as retinol binding protein 3 (RBP3), is a lipophilic glycoprotein specifically secreted by photoreceptors.
Shaoxue Zeng, Shaoxue Zeng, Ting Zhang, Michele C. Madigan, Michele C. Madigan, Nilisha Fernando, Riemke Aggio-Bruce, Riemke Aggio-Bruce, Fanfan Zhou, Matthew Pierce, Yingying Chen, Yingying Chen, Lianlin Huang, Lianlin Huang, Riccardo Natoli, Riccardo Natoli, Mark C. Gillies, Ling Zhu   +17 more
doaj   +1 more source