Regulation of retinoid-mediated signaling involved in skin homeostasis by RAR and RXR agonists/antagonists in mouse skin. [PDF]
PLoS ONE, 2013 Endogenous retinoids like all-trans retinoic acid (ATRA) play important roles in skin homeostasis and skin-based immune responses. Moreover, retinoid signaling was found to be dysregulated in various skin diseases.
Janine Gericke +7 more
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Targeting PRAME directly or via EZH2 inhibition overcomes retinoid resistance and represents a novel therapy for keratinocyte carcinoma [PDF]
Molecular OncologyRetinoids have demonstrated efficacy as preventative/treatment agents for keratinocyte carcinomas (KCs): basal cell carcinoma (BCC) and cutaneous squamous cell carcinoma (SCC). However, retinoid resistance mechanisms limit the efficacy of these compounds.
Brandon Ramchatesingh +6 more
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Possible Therapeutics for Pseudomyxoma Peritonei: A Rare, Lethal, and the Least Investigated Disease
Journal of Coloproctology, 2023 Pseudomyxoma peritonei (PMP) refers to a growth disorder characterized by glycoprotein neoplasm in the peritoneum, where mucin oversecretion occurs.
Aarifa Nazmeen
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Frontiers in Molecular Biosciences, 2022 Carotenoid metabolism is critical for diverse physiological processes. The nematode Caenorhabditis elegans has two genes that are annotated as β-carotene 15,15′-monooxygenase (BCMO) and are 17 centimorgan apart on chromosome II, but the function of BCMO ...
Weimin Pan +7 more
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Frontiers in Immunology, 2022 Altering T cell trafficking to mucosal regions can enhance immune responses towards pathogenic infections and cancers at these sites, leading to better outcomes.
Kavita R. Manhas +6 more
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The Transcriptional Role of Vitamin A and the Retinoid Axis in Brown Fat Function
Frontiers in Endocrinology, 2020 In recent years, brown adipose tissue (BAT) has gained significance as a metabolic organ dissipating energy through heat production. Promotion of a thermogenic program in fat holds great promise as potential therapeutic tool to counteract weight gain and
Carsten T. Herz, Florian W. Kiefer
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Advances and challenges in retinoid delivery systems in regenerative and therapeutic medicine
Nature Communications, 2020 Retinoids regulate a wide spectrum of cellular functions from the embryo throughout adulthood, including cell differentiation, metabolic regulation, and inflammation. These traits make retinoids very attractive molecules for medical purposes. In light of
R. Ferreira +4 more
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Interphotoreceptor Retinoid-Binding Protein (IRBP) in Retinal Health and Disease
Frontiers in Cellular Neuroscience, 2020 Interphotoreceptor retinoid-binding protein (IRBP), also known as retinol binding protein 3 (RBP3), is a lipophilic glycoprotein specifically secreted by photoreceptors.
Shaoxue Zeng +17 more
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Improvements in acne and skin oiliness with tazarotene 0.045% lotion in patients with oily skin
Journal of Dermatological Treatment, 2023 Background Excessive sebum production is a factor in acne development. Tazarotene 0.045% lotion has demonstrated reductions in acne lesions and acne-induced sequelae. Objective Evaluate efficacy, changes in skin oiliness, and safety with tazarotene 0.045%
Emil A. Tanghetti +10 more
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Microbial Production of Bioactive Retinoic Acid Using Metabolically Engineered Escherichia coli
Microorganisms, 2021 Microbial production of bioactive retinoids, including retinol and retinyl esters, has been successfully reported. Previously, there are no reports on the microbial biosynthesis of retinoic acid.
Minjae Han, Pyung Cheon Lee
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