Results 31 to 40 of about 121,956 (356)
Nuclear Receptors as Therapeutic Targets for Neurodegenerative Diseases: Lost in Translation [PDF]
, 2019 Neurodegenerative diseases are characterized by a progressive loss of neurons that leads to a broad range of disabilities, including severe cognitive decline and motor impairment, for which there are no effective therapies.
Codocedo, Juan F. +3 more
core +1 more source
Journal of Cell Biology, 2015 Activation of retinoid X receptor γ and vitamin D receptor (VDR) heterodimer via vitamin D enhances oligodendrocyte progenitor differentiation, whereas blocking VDR impairs differentiation and myelination ex vivo.
A. G. de la Fuente +12 more
semanticscholar +1 more source
A review about lycopene-induced nuclear hormone receptor signalling in inflammation and lipid metabolism via still unknown endogenous apo-10´-lycopenoids [PDF]
, 2016 Lycopene is the red pigment in tomatoes and tomato products and is an important dietary carotenoid found in the human organism. Lycopene-isomers, oxidative lycopene metabolites and apo-lycopenoids are found in the food matrix.
Aydemir, Gamze +5 more
core +1 more source
Systemic retinoids and scar dehiscence
Indian Journal of Dermatology, 2019 Systemic retinoids such as isotretinoin and acitretin are associated with numerous side effects but are therapeutically valuable in dermatological practice.
Hasan Mete Aksoy, Berna Aksoy
doaj +1 more source
Potential Effects of Oral Isotretinoin on Growth Plate and Height
Endocrines, 2023 Longitudinal growth and puberty are the result of a complex interaction of genetic, hormonal, nutritional, and environmental factors. Acne vulgaris is a chronic disease of the pilosebaceous unit that affects 85% of adolescents worldwide.
Adriane A. Cardoso-Demartini +2 more
doaj +1 more source
Catalytic mechanism of a retinoid isomerase essential for vertebrate vision
Nature Chemical Biology, 2015 Visual function in vertebrates is dependent on the membrane-bound retinoid isomerase, RPE65, an essential component of the retinoid cycle pathway that regenerates 11-cis-retinal for rod and cone opsins.
P. Kiser +8 more
semanticscholar +1 more source
Role of vitamin A/retinoic acid in regulation of embryonic and adult hematopoiesis [PDF]
, 2017 Vitamin A is an essential micronutrient throughout life. Its physiologically active metabolite retinoic acid (RA), acting through nuclear retinoic acid receptors (RARs), is a potent regulator of patterning during embryonic development, as well as being ...
Adamo +23 more
core +4 more sources
Assessing the Safety and Efficacy of Trifarotene in the Treatment of Acne Vulgaris
Therapeutics and Clinical Risk Management, 2021 Caitlin M Brumfiel,1 Meera H Patel,2 Katheryn A Bell,1 Michael A Cardis3 1Georgetown University School of Medicine, Washington, DC, USA; 2Creighton University School of Medicine, Phoenix Regional Campus, Phoenix, AZ, USA; 3MedStar Washington Hospital ...
Brumfiel CM +3 more
doaj
Epigenetic Silencing of Cellular Retinol-Binding Proteins in Nasopharyngeal Carcinoma
Neoplasia: An International Journal for Oncology Research, 2005 Aberrant retinoid signaling in human cancers is extending from the nucleus to the cytoplasm. Recently, we have demonstrated frequent epigenetic inactivation of a retinoic acid receptor (RAR), RARβ2, in nasopharyngeal carcinoma (NPC).
Joseph Kwong +7 more
doaj +1 more source
Biomolecules, 2019 During development, growth cones are essential for axon pathfinding by sensing numerous guidance cues in their environment. Retinoic acid, the metabolite of vitamin A, is important for neurite outgrowth during vertebrate development, but may also play a ...
Alysha Johnson +2 more
doaj +1 more source