Results 31 to 40 of about 131,717 (361)
Blue light regenerates functional visual pigments in mammals through a retinyl-phospholipid intermediate. [PDF]
, 2017 The light absorbing chromophore in opsin visual pigments is the protonated Schiff base of 11-cis-retinaldehyde (11cRAL). Absorption of a photon isomerizes 11cRAL to all-trans-retinaldehyde (atRAL), briefly activating the pigment before it dissociates ...
Fain, Gordon L +6 more
core +1 more source
Retinoid-binding proteins: mediators of retinoid action [PDF]
Biochemical Journal, 2000 Active vitamin A metabolites, known as retinoids, are essential for multiple physiological processes, ranging from vision to embryonic development. These small hydrophobic compounds associate in vivo with soluble proteins that are present in a variety of cells and in particular extracellular compartments, and which bind different types of retinoids ...
openaire +2 more sources
LXR, a nuclear receptor that defines a distinct retinoid response pathway.
Genes & Development, 1995 We have identified a new retinoid response pathway through which 9-cis retinoic acid (9cRA) activates transcription in the presence of LXR alpha, a member of the nuclear receptor superfamily.
P. J. Willy +5 more
semanticscholar +1 more source
Sterol-dependent transactivation of the ABC1 promoter by the liver X receptor/retinoid X receptor.
Journal of Biological Chemistry, 2000 Tangier disease, a condition characterized by low levels of high density lipoprotein and cholesterol accumulation in macrophages, is caused by mutations in the ATP-binding cassette transporter ABC1.
P. Costet, Yi Luo, Nan Wang, A. Tall
semanticscholar +1 more source
Pharmaceutics, 2022 Retinoids, one of the most robust bioactive materials, have been widely used to improve various dermatological and pathological conditions. The body has an endogenous mechanism that modulates the exogenous retinoid above physiological concentrations ...
Seongsu Kang +4 more
doaj +1 more source
Advances in Preventive Therapy for Estrogen-Receptor-Negative Breast Cancer. [PDF]
, 2014 Preventing breast cancer is an effective strategy for reducing breast cancer deaths. The purpose of chemoprevention (also termed preventive therapy) is to reduce cancer incidence by use of natural, synthetic, or biological agents.
Brown, Powel H, Litzenburger, Beate C
core +1 more source
Identification of novel NRF2-regulated genes by ChIP-Seq: influence on retinoid X receptor alpha
Nucleic Acids Research, 2012 Cellular oxidative and electrophilic stress triggers a protective response in mammals regulated by NRF2 (nuclear factor (erythroid-derived) 2-like; NFE2L2) binding to deoxyribonucleic acid-regulatory sequences near stress-responsive genes.
B. Chorley +9 more
semanticscholar +1 more source
Journal of Cell Biology, 2015 Activation of retinoid X receptor γ and vitamin D receptor (VDR) heterodimer via vitamin D enhances oligodendrocyte progenitor differentiation, whereas blocking VDR impairs differentiation and myelination ex vivo.
A. G. de la Fuente +12 more
semanticscholar +1 more source
Rat models of autoimmune uveitis [PDF]
, 2008 Experimental autoimmune uveitis ( EAU) in Lewis rats is a well-established model for human uveitis. During the last years we used this model to demonstrate extraocular induction of uveitis by antigenic mimicry of environmental antigens with retinal ...
Diedrichs-Moehring, Maria +2 more
core +1 more source
Microbial Production of Retinyl Palmitate and Its Application as a Cosmeceutical
Antioxidants, 2020 Chemically synthesized retinyl palmitate has been widely used in the cosmetic and biotechnology industry. In this study, we aimed to demonstrate the microbial production of retinyl palmitate and the benefits of microbial retinyl palmitate in skin ...
Bo Hyun Choi +6 more
doaj +1 more source