Results 191 to 200 of about 6,765,357 (233)

Retinoid X receptor and its partners in the nuclear receptor family

Current Opinion in Structural Biology, 2001
Retinoid X receptor (RXR) and its dimerization partners in the nuclear receptor family recognize DNA response elements in which two AGGTCA binding sites are arranged in tandem. Target site selection by these complexes requires the spacing between the binding sites to act as the identity element.
F Rastinejad
exaly   +4 more sources

Retinoid X receptor activation reverses age-related deficiencies in myelin debris phagocytosis and remyelination [PDF]

Brain, 2015
The efficiency of central nervous system remyelination declines with age. This is in part due to an age-associated decline in the phagocytic removal of myelin debris, which contains inhibitors of oligodendrocyte progenitor cell differentiation.
Robin Franklin, Alerie Guzman de la Fuente, Bibiana Bielekova   +2 more
exaly   +5 more sources

Some of the next articles are maybe not open access.

Related searches:

Retinoid X receptors and retinoid response in neuroblastoma cells

Journal of Cellular Biochemistry, 2002
AbstractRetinoic acid (RA) modulates differentiation and apoptosis of neural cells via RA receptors (RARs) and retinoid X receptors (RXRs). Neuroblastoma cells are potentially useful models for elucidating the molecular mechanisms of RA in neural cells, and responses to different isomers of RA have been interpreted in terms of differential homo‐ and ...
Rana, B., Veal, G.J., Pearson, A.D.J., Redfern, C.P.F.   +7 more
openaire   +3 more sources

Synthesis of Novel Retinoid X Receptor-Selective Retinoids

The Journal of Organic Chemistry, 2001
Retinoids 1-5 have been identified as potent RXR agonists for evaluation in the treatment of non-insulin-dependent (type II) diabetes mellitus (NIDDM). Highly convergent syntheses of 1-5 have been developed. The core tetrahydronaphthalene 7, employed in the synthesis of 1 and 2, was prepared in 98% yield using an AlCl(3)-catalyzed (0.03 equiv) Friedel ...
M M, Faul, A M, Ratz, K A, Sullivan, W G, Trankle, L L, Winneroski   +4 more
openaire   +2 more sources

Retinoids Selective for Retinoid X Receptor Response Pathways

Science, 1992
Retinoids have a broad spectrum of biological activities and are useful therapeutic agents. Their physiological activities are mediated by two types of receptors, the retinoic acid receptors (RARs) and the retinoid X receptors (RXRs). RARs, as well as several related receptors, require heterodimerization with RXRs for effective DNA binding
J M, Lehmann, L, Jong, A, Fanjul, J F, Cameron, X P, Lu, P, Haefner, M I, Dawson, M, Pfahl   +7 more
openaire   +2 more sources