Results 191 to 200 of about 57,833 (232)

Retinoid X receptors and retinoid response in neuroblastoma cells

Journal of Cellular Biochemistry, 2002
AbstractRetinoic acid (RA) modulates differentiation and apoptosis of neural cells via RA receptors (RARs) and retinoid X receptors (RXRs). Neuroblastoma cells are potentially useful models for elucidating the molecular mechanisms of RA in neural cells, and responses to different isomers of RA have been interpreted in terms of differential homo‐ and ...
Rana, B., Veal, G.J., Pearson, A.D.J., Redfern, C.P.F.   +7 more
openaire   +3 more sources

Retinoids Selective for Retinoid X Receptor Response Pathways

Science, 1992
Retinoids have a broad spectrum of biological activities and are useful therapeutic agents. Their physiological activities are mediated by two types of receptors, the retinoic acid receptors (RARs) and the retinoid X receptors (RXRs). RARs, as well as several related receptors, require heterodimerization with RXRs for effective DNA binding
J M, Lehmann, L, Jong, A, Fanjul, J F, Cameron, X P, Lu, P, Haefner, M I, Dawson, M, Pfahl   +7 more
openaire   +2 more sources

Synthesis of Novel Retinoid X Receptor-Selective Retinoids

The Journal of Organic Chemistry, 2001
Retinoids 1-5 have been identified as potent RXR agonists for evaluation in the treatment of non-insulin-dependent (type II) diabetes mellitus (NIDDM). Highly convergent syntheses of 1-5 have been developed. The core tetrahydronaphthalene 7, employed in the synthesis of 1 and 2, was prepared in 98% yield using an AlCl(3)-catalyzed (0.03 equiv) Friedel ...
M M, Faul, A M, Ratz, K A, Sullivan, W G, Trankle, L L, Winneroski   +4 more
openaire   +2 more sources

Retinoid X receptor and its partners in the nuclear receptor family

Current Opinion in Structural Biology, 2001
Retinoid X receptor (RXR) and its dimerization partners in the nuclear receptor family recognize DNA response elements in which two AGGTCA binding sites are arranged in tandem. Target site selection by these complexes requires the spacing between the binding sites to act as the identity element.
Fraydoon Rastinejad
exaly   +3 more sources

Retinoid X receptors

The International Journal of Biochemistry & Cell Biology, 1997
Retinoids are metabolites of retinol (vitamin A), which act as signalling molecules in embryogenesis and as stimulators of cellular differentiation. The potency of retinoids as differentiating agents has led to their successful use in treating skin diseases and some forms of cancer.
openaire   +2 more sources

Identification of an Activator of the Retinoid X Receptor

Journal of Natural Products, 1994
A metabolite of all-trans retinoic acid produced by insect cells was discovered to activate the intracellular retinoic acid X receptor. The compound, beta-glucopyranosyl 9-cis-retinoate [1], was purified and its structure was determined by analysis of spectroscopic data.
C, Pathirana, R A, Heyman, S B, Lazarchik   +2 more
openaire   +2 more sources

Aza-retinoids as novel retinoid X receptor-specific agonists

Bioorganic & Medicinal Chemistry Letters, 2006
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Luc J, Farmer, Kristen S, Marron, Stacie S, Canan Koch, C K, Hwang, E Adam, Kallel, Lin, Zhi, Alex M, Nadzan, Dave W, Robertson, Youssef L, Bennani   +8 more
openaire   +2 more sources

Retinoid X Receptor Heterodimers in the Metabolic Syndrome

New England Journal of Medicine, 2005
To the Editor: The excellent review of nuclear receptors by Shulman and Mangelsdorf (Aug. 11 issue)1 mentioned that the study of patients with mutations in PPARγ, the gene encoding peroxisome-proliferator–activated receptor γ (PPARγ), which is rare, can yield corroborating and new insights into the metabolic syndrome.
Andrew I, Shulman, David J, Mangelsdorf
openaire   +4 more sources

Diminished teratogenicity of retinoid X receptor-selective synthetic retinoids

Biochemical Pharmacology, 1995
One feature that contraindicates the wide therapeutic use of retinoids is their teratogenicity. Synthetic retinoids are distinguishable from each other on the basis of their partial or exclusive preference in binding and activation of all-trans retinoic acid receptors (RARs) or retinoid X receptors (RXRs). Using mouse embryo limb bud cells in micromass
H, Jiang, J D, Penner, R L, Beard, R A, Chandraratna, D M, Kochhar   +4 more
openaire   +2 more sources

Limited Degradation of Retinoid X Receptor by Calpain

Biochemical and Biophysical Research Communications, 1996
Recently, we have found two major physiological forms of retinoid X receptor alpha (RXR alpha): the mature 54 kDa RXR alpha and the truncated 44 kDa RXR alpha lacking a portion of N-terminal A/B domain in human and rodent livers. In this communication, we show that m-calpain was active to digest 54 kDa RXR alpha in the human hepatoma-derived cell line,
R, Matsushima-Nishiwaki, Y, Shidoji, S, Nishiwaki, H, Moriwaki, Y, Muto   +4 more
openaire   +2 more sources