Results 201 to 210 of about 6,765,357 (233)

Retinoid X receptors

The International Journal of Biochemistry & Cell Biology, 1997
Retinoids are metabolites of retinol (vitamin A), which act as signalling molecules in embryogenesis and as stimulators of cellular differentiation. The potency of retinoids as differentiating agents has led to their successful use in treating skin diseases and some forms of cancer.
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Identification of an Activator of the Retinoid X Receptor

Journal of Natural Products, 1994
A metabolite of all-trans retinoic acid produced by insect cells was discovered to activate the intracellular retinoic acid X receptor. The compound, beta-glucopyranosyl 9-cis-retinoate [1], was purified and its structure was determined by analysis of spectroscopic data.
C, Pathirana, R A, Heyman, S B, Lazarchik   +2 more
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Aza-retinoids as novel retinoid X receptor-specific agonists

Bioorganic & Medicinal Chemistry Letters, 2006
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Luc J, Farmer, Kristen S, Marron, Stacie S, Canan Koch, C K, Hwang, E Adam, Kallel, Lin, Zhi, Alex M, Nadzan, Dave W, Robertson, Youssef L, Bennani   +8 more
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Diminished teratogenicity of retinoid X receptor-selective synthetic retinoids

Biochemical Pharmacology, 1995
One feature that contraindicates the wide therapeutic use of retinoids is their teratogenicity. Synthetic retinoids are distinguishable from each other on the basis of their partial or exclusive preference in binding and activation of all-trans retinoic acid receptors (RARs) or retinoid X receptors (RXRs). Using mouse embryo limb bud cells in micromass
H, Jiang, J D, Penner, R L, Beard, R A, Chandraratna, D M, Kochhar   +4 more
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Retinoid X Receptor Heterodimers in the Metabolic Syndrome

New England Journal of Medicine, 2005
The principal abnormalities of the metabolic syndrome are abdominal obesity, atherogenic dyslipidemia, hypertension, insulin resistance, inflammation, and prothrombotic states.
Andrew I, Shulman, David J, Mangelsdorf
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Determinants of Retinoid X Receptor Transcriptional Antagonism

Journal of Medicinal Chemistry, 2004
The synthesis and bioactivity of the retinoid X receptor (RXR) antagonist 4-[(3'-n-butyl-5',6',7',8'-tetrahydro-5',5',8',8'-tetramethyl-2'-naphthalenyl)(cyclopropylidene)methyl]benzoic acid and several heteroatom-substituted analogues are described. Ligand design was based on the scaffold of the 3'-methyl RXR-selective agonist analogue and reports that
Claudio N, Cavasotto, Gang, Liu, Sharon Y, James, Peter D, Hobbs, Valerie J, Peterson, Ananyo A, Bhattacharya, Siva K, Kolluri, Xiao-kun, Zhang, Mark, Leid, Ruben, Abagyan, Robert C, Liddington, Marcia I, Dawson   +11 more
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Limited Degradation of Retinoid X Receptor by Calpain

Biochemical and Biophysical Research Communications, 1996
Recently, we have found two major physiological forms of retinoid X receptor alpha (RXR alpha): the mature 54 kDa RXR alpha and the truncated 44 kDa RXR alpha lacking a portion of N-terminal A/B domain in human and rodent livers. In this communication, we show that m-calpain was active to digest 54 kDa RXR alpha in the human hepatoma-derived cell line,
R, Matsushima-Nishiwaki, Y, Shidoji, S, Nishiwaki, H, Moriwaki, Y, Muto   +4 more
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Cloning of crustacean ecdysteroid receptor and retinoid-X receptor gene homologs and elevation of retinoid-X receptor mRNA by retinoic acid

Molecular and Cellular Endocrinology, 1998
We report the cloning and analysis of ecdysteroid receptor (bpEcR) and retinoid-X receptor (UpRXR) cDNA homologs from the fiddler crab Uca pugilator. The deduced amino acid sequence of this crustacean EcR most closely resembles the insect EcRs within the DNA binding and ligand binding domains (LBDs).
A C, Chung, D S, Durica, S W, Clifton, B A, Roe, P M, Hopkins   +4 more
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Heterodimerization of the Drosophila ecdysone receptor with retinoid X receptor and ultraspiracle

Nature, 1993
Ecdysone in Drosophila has been a paradigm for steroid hormones since its ability to induce gene activity directly was demonstrated by its effects on moulting and polytene chromosome puffing. The ecdysone receptor (EcR) was recently confirmed as a member of the nuclear receptor superfamily by cloning and characterization in a Drosophila cell line. Here
H E, Thomas, H G, Stunnenberg, A F, Stewart   +2 more
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Vitamin D receptor and retinoid X receptor interactions in motion

2002
Vitamin D receptor (VDR) and retinoid X receptor (RXR) are members of the nuclear receptor superfamily and they bind target DNA sequences as heterodimers to regulate transcription. This article surveys the latest findings regarding the roles of dimerizing RXR in VDR function and emphasizes potential areas for future developments. We first highlight the
J, Barsony, K, Prufer
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