Results 201 to 210 of about 57,833 (232)

Determinants of Retinoid X Receptor Transcriptional Antagonism

Journal of Medicinal Chemistry, 2004
The synthesis and bioactivity of the retinoid X receptor (RXR) antagonist 4-[(3'-n-butyl-5',6',7',8'-tetrahydro-5',5',8',8'-tetramethyl-2'-naphthalenyl)(cyclopropylidene)methyl]benzoic acid and several heteroatom-substituted analogues are described. Ligand design was based on the scaffold of the 3'-methyl RXR-selective agonist analogue and reports that
Claudio N, Cavasotto, Gang, Liu, Sharon Y, James, Peter D, Hobbs, Valerie J, Peterson, Ananyo A, Bhattacharya, Siva K, Kolluri, Xiao-kun, Zhang, Mark, Leid, Ruben, Abagyan, Robert C, Liddington, Marcia I, Dawson   +11 more
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Cloning of crustacean ecdysteroid receptor and retinoid-X receptor gene homologs and elevation of retinoid-X receptor mRNA by retinoic acid

Molecular and Cellular Endocrinology, 1998
We report the cloning and analysis of ecdysteroid receptor (bpEcR) and retinoid-X receptor (UpRXR) cDNA homologs from the fiddler crab Uca pugilator. The deduced amino acid sequence of this crustacean EcR most closely resembles the insect EcRs within the DNA binding and ligand binding domains (LBDs).
A C, Chung, D S, Durica, S W, Clifton, B A, Roe, P M, Hopkins   +4 more
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Heterodimerization of the Drosophila ecdysone receptor with retinoid X receptor and ultraspiracle

Nature, 1993
Ecdysone in Drosophila has been a paradigm for steroid hormones since its ability to induce gene activity directly was demonstrated by its effects on moulting and polytene chromosome puffing. The ecdysone receptor (EcR) was recently confirmed as a member of the nuclear receptor superfamily by cloning and characterization in a Drosophila cell line. Here
H E, Thomas, H G, Stunnenberg, A F, Stewart   +2 more
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Conformational Effects on Retinoid Receptor Selectivity. 2. Effects of Retinoid Bridging Group on Retinoid X Receptor Activity and Selectivity

Journal of Medicinal Chemistry, 1995
The natural retinoid 9-cis-retinoic acid is an activating ligand for both the retinoic acid receptors (RARs) and the retinoid X receptors (RXRs), which are members of the retinoid/thyroid hormone/steroid hormone family of nuclear receptor proteins that activate gene transcription through specific response elements.
M I, Dawson, L, Jong, P D, Hobbs, J F, Cameron, W R, Chao, M, Pfahl, M O, Lee, B, Shroot, M, Pfahl   +8 more
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Vitamin D receptor and retinoid X receptor interactions in motion

2002
Vitamin D receptor (VDR) and retinoid X receptor (RXR) are members of the nuclear receptor superfamily and they bind target DNA sequences as heterodimers to regulate transcription. This article surveys the latest findings regarding the roles of dimerizing RXR in VDR function and emphasizes potential areas for future developments. We first highlight the
J, Barsony, K, Prufer
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Characterization of synthetic retinoids with selectivity for retinoic acid or retinoid X nuclear receptors

Biochimica et Biophysica Acta (BBA) - General Subjects, 1996
The broad spectrum of physiological activities of retinoids is mediate d by two types of receptors, the retinoic acid receptors (RARs) and the retinoid X receptors (RXRs). Though they have 9-cis retinoic acid as a common ligand, the amino acid sequence of their ligand binding domains is only distantly related (27%). This fact makes it probable that the
P K, LeMotte, S, Keidel, C M, Apfel
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Expression of the human ABCC6 gene is induced by retinoids through the retinoid X receptor

Biochemical and Biophysical Research Communications, 2006
Mutations in the human ABCC6 gene are responsible for the disease pseudoxanthoma elasticum, although the physiological function or substrate of the gene product (an ABC transporter known also as MRP6) is not known. We found that the expression of this gene in cells of hepatic origin (where this gene is predominantly expressed in the body) is ...
Marcin, Ratajewski, Grzegorz, Bartosz, Lukasz, Pulaski   +2 more
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Synthesis and Structure-Activity Relationships of Novel Retinoid X Receptor-Selective Retinoids

Journal of Medicinal Chemistry, 1994
Two series of potent retinoid X receptor (RXR)-selective compounds were designed and synthesized based upon recent observation that (E)-4-[2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-2-naphthalenyl)-1- propenyl]benzoic acid (TTNBP) binds and transactivates only the retinoic acid receptor (RAR) subtypes whereas (E)-4-[2-(3,5,5,8,8-pentamethyl-5,6,7,8 ...
M F, Boehm, L, Zhang, B A, Badea, S K, White, D E, Mais, E, Berger, C M, Suto, M E, Goldman, R A, Heyman   +8 more
openaire   +2 more sources

Retinoid-X receptor signalling in the developing spinal cord

Nature, 1998
Retinoids regulate gene expression through the action of retinoic acid receptors (RARs) and retinoid-X receptors (RXRs), which both belong to the family of nuclear hormone receptors. Retinoids are of fundamental importance during development, but it has been difficult to assess the distribution of ligand-activated receptors in vivo.
L, Solomin, C B, Johansson, R H, Zetterström, R P, Bissonnette, R A, Heyman, L, Olson, U, Lendahl, J, Frisén, T, Perlmann   +8 more
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Retinoid X Receptor

2006
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