Results 1 to 10 of about 25,727 (222)

Insulin-induced serine 22 phosphorylation of retinoid X receptor alpha is dispensable for adipogenesis in brown adipocytes [PDF]

Adipocyte, 2020
Insulin action initiates a series of phosphorylation events regulating cellular differentiation, growth and metabolism. We have previously discovered, in a mass spectrometry-based phosphoproteomic study, that insulin/IGF-1 signalling induces ...
Jacob Ardenkjær-Larsen, Kaja Rupar, Goda Sinkevičiūtė, Patricia S. S. Petersen, Julia Villarroel, Morten Lundh, Romain Barrès, Atefeh Rabiee, Brice Emanuelli   +8 more
doaj   +12 more sources

Modulating retinoid-X-receptor alpha (RXRA) expression sensitizes chronic myeloid leukemia cells to imatinib in vitro and reduces disease burden in vivo [PDF]

Frontiers in Pharmacology, 2023
Introduction: The ligand-activated transcription factors, nuclear hormone receptors (NHRs), remain unexplored in hematological malignancies except for retinoic acid receptor alpha (RARA).Methods: Here we profiled the expression of various NHRs and their ...
Bharathi M. Rajamani, Bharathi M. Rajamani, Raveen Stephen Stallon Illangeswaran, Raveen Stephen Stallon Illangeswaran, Esther Sathya Bama Benjamin, Esther Sathya Bama Benjamin, Balaji Balakrishnan, Balaji Balakrishnan, Daniel Zechariah Paul Jebanesan, Daniel Zechariah Paul Jebanesan, Saswati Das, Saswati Das, Aswin Anand Pai, Aswin Anand Pai, Rakhi Thalayattu Vidhyadharan, Ajith Mohan, Sreeja Karathedath, Aby Abraham, Vikram Mathews, Shaji R. Velayudhan, Shaji R. Velayudhan, Poonkuzhali Balasubramanian   +21 more
doaj   +5 more sources

The importance of the retinoid X receptor alpha in modulating inflammatory signaling in acute murine colitis. [PDF]

Dig Dis Sci, 2014
In order for vitamin D to signal and regulate inflammatory pathways, it must bind to its receptor (VDR) which must heterodimerize with the retinoid X receptor alpha (RXRα). Although the role that vitamin D signaling plays in the development and progression of colitis, a disease characterized by excessive inflammation, has been suggested, little ...
Knackstedt R, Shaoli S, Moseley V, Wargovich M.   +3 more
europepmc   +8 more sources

Retinoid X receptor alpha is a spatiotemporally predominant therapeutic target for anthracycline-induced cardiotoxicity. [PDF]

Sci Adv, 2020
RXRA is an endothelial- and early stage–predominant therapeutic target for treating anthracycline-induced cardiotoxicity. To uncover the genetic basis of anthracycline-induced cardiotoxicity (AIC), we recently established a genetic suppressor screening ...
Ma X, Zhu P, Ding Y, Zhang H, Qiu Q, Dvornikov AV, Wang Z, Kim M, Wang Y, Lowerison M, Yu Y, Norton N, Herrmann J, Ekker SC, Hsiai TK, Lin X, Xu X.   +16 more
europepmc   +7 more sources

Antagonist effect of triptolide on AKT activation by truncated retinoid X receptor-alpha. [PDF]

PLoS ONE, 2012
BACKGROUND: Retinoid X receptor-alpha (RXRα) is a key member of the nuclear receptor superfamily. We recently demonstrated that proteolytic cleavage of RXRα resulted in production of a truncated product, tRXRα, which promotes cancer cell survival by ...
Na Lu, Jinxing Liu, Jie Liu, Chunyun Zhang, Fuquan Jiang, Hua Wu, Liqun Chen, Wenjun Zeng, Xihua Cao, Tingdong Yan, Guanghui Wang, Hu Zhou, Bingzhen Lin, Xiaomei Yan, Xiao-kun Zhang, Jin-Zhang Zeng   +15 more
doaj   +8 more sources

Identification of novel NRF2-regulated genes by ChIP-Seq: influence on retinoid X receptor alpha. [PDF]

Nucleic Acids Res, 2012
Cellular oxidative and electrophilic stress triggers a protective response in mammals regulated by NRF2 (nuclear factor (erythroid-derived) 2-like; NFE2L2) binding to deoxyribonucleic acid-regulatory sequences near stress-responsive genes.
Chorley BN, Campbell MR, Wang X, Karaca M, Sambandan D, Bangura F, Xue P, Pi J, Kleeberger SR, Bell DA.   +9 more
europepmc   +7 more sources

Association of Retinoid X Receptor Alpha Gene Polymorphism with Clinical Course of Chronic Glomerulonephritis. [PDF]

Med Sci Monit, 2015
Background Vitamin D (VD), VD binding protein, VD receptor (VDR), and retinoids are involved in pathogenesis of chronic glomerulonephritis (ChGN). We aimed to compare distribution of VD pathway gene polymorphisms in ChGN patients showing glomerular ...
Grzegorzewska AE, Ostromecki G, Zielińska P, Mostowska A, Niemir Z, Polcyn-Adamczak M, Pawlik M, Sowińska A, Jagodziński PP.   +8 more
europepmc   +7 more sources

Sexually dimorphic genome-wide binding of retinoid X receptor alpha (RXRα) determines male-female differences in the expression of hepatic lipid processing genes in mice. [PDF]

PLoS ONE, 2013
Many hepatic functions including lipid metabolism, drug metabolism, and inflammatory responses are regulated in a sex-specific manner due to distinct patterns of hepatic gene expression between males and females.
Astrid Kosters, Deqiang Sun, Hao Wu, Feng Tian, Julio C Felix, Wei Li, Saul J Karpen   +6 more
doaj   +5 more sources

Serine 350 of human pregnane X receptor is crucial for its heterodimerization with retinoid X receptor alpha and transactivation of target genes in vitro and in vivo. [PDF]

Biochem Pharmacol, 2015
The human pregnane X receptor (hPXR), a member of the nuclear receptor superfamily, senses xenobiotics and controls the transcription of genes encoding drug-metabolizing enzymes and transporters. The regulation of hPXR's transcriptional activation of its target genes is important for xenobiotic detoxification and endobiotic metabolism, and hPXR ...
Wang YM, Chai SC, Lin W, Chai X, Elias A, Wu J, Ong SS, Pondugula SR, Beard JA, Schuetz EG, Zeng S, Xie W, Chen T.   +12 more
europepmc   +7 more sources

A Novel in Duck Myoblasts: The Transcription Factor Retinoid X Receptor Alpha (RXRA) Inhibits Lipid Accumulation by Promoting CD36 Expression. [PDF]

Int J Mol Sci, 2023
Retinoid X receptor alpha (RXRA) is a well-characterized factor that regulates lipid metabolism; however, the regulatory mechanism in muscle cells of poultry is still unknown. The overexpression and the knockdown of RXRA in myoblasts (CS2 cells), RT-PCR,
Pan Z, Chen X, Wu D, Li X, Gao W, Li G, Du G, Zhang C, Jin S, Geng Z.   +9 more
europepmc   +4 more sources