Results 1 to 10 of about 14,401 (197)

Antagonist effect of triptolide on AKT activation by truncated retinoid X receptor-alpha. [PDF]

PLoS ONE, 2012
BACKGROUND: Retinoid X receptor-alpha (RXRα) is a key member of the nuclear receptor superfamily. We recently demonstrated that proteolytic cleavage of RXRα resulted in production of a truncated product, tRXRα, which promotes cancer cell survival by ...
Na Lu, Jinxing Liu, Jie Liu, Chunyun Zhang, Fuquan Jiang, Hua Wu, Liqun Chen, Wenjun Zeng, Xihua Cao, Tingdong Yan, Guanghui Wang, Hu Zhou, Bingzhen Lin, Xiaomei Yan, Xiao-kun Zhang, Jin-Zhang Zeng   +15 more
doaj   +7 more sources

Insulin-induced serine 22 phosphorylation of retinoid X receptor alpha is dispensable for adipogenesis in brown adipocytes [PDF]

Adipocyte, 2020
Insulin action initiates a series of phosphorylation events regulating cellular differentiation, growth and metabolism. We have previously discovered, in a mass spectrometry-based phosphoproteomic study, that insulin/IGF-1 signalling induces ...
Jacob Ardenkjær-Larsen, Kaja Rupar, Goda Sinkevičiūtė, Patricia S. S. Petersen, Julia Villarroel, Morten Lundh, Romain Barrès, Atefeh Rabiee, Brice Emanuelli   +8 more
doaj   +5 more sources

Modulating retinoid-X-receptor alpha (RXRA) expression sensitizes chronic myeloid leukemia cells to imatinib in vitro and reduces disease burden in vivo [PDF]

Frontiers in Pharmacology, 2023
Introduction: The ligand-activated transcription factors, nuclear hormone receptors (NHRs), remain unexplored in hematological malignancies except for retinoic acid receptor alpha (RARA).Methods: Here we profiled the expression of various NHRs and their ...
Bharathi M. Rajamani, Bharathi M. Rajamani, Raveen Stephen Stallon Illangeswaran, Raveen Stephen Stallon Illangeswaran, Esther Sathya Bama Benjamin, Esther Sathya Bama Benjamin, Balaji Balakrishnan, Balaji Balakrishnan, Daniel Zechariah Paul Jebanesan, Daniel Zechariah Paul Jebanesan, Saswati Das, Saswati Das, Aswin Anand Pai, Aswin Anand Pai, Rakhi Thalayattu Vidhyadharan, Ajith Mohan, Sreeja Karathedath, Aby Abraham, Vikram Mathews, Shaji R. Velayudhan, Shaji R. Velayudhan, Poonkuzhali Balasubramanian   +21 more
doaj   +4 more sources

Association of Retinoid X Receptor Alpha Gene Polymorphism with Clinical Course of Chronic Glomerulonephritis. [PDF]

Med Sci Monit, 2015
BACKGROUND Vitamin D (VD), VD binding protein, VD receptor (VDR), and retinoids are involved in pathogenesis of chronic glomerulonephritis (ChGN). We aimed to compare distribution of VD pathway gene polymorphisms in ChGN patients showing glomerular filtration rate (GFR) category 1-3, GFR category 5D, and healthy controls in order to elucidate the role ...
Grzegorzewska AE, Ostromecki G, Zielińska P, Mostowska A, Niemir Z, Polcyn-Adamczak M, Pawlik M, Sowińska A, Jagodziński PP.   +8 more
europepmc   +6 more sources

Sexually dimorphic genome-wide binding of retinoid X receptor alpha (RXRα) determines male-female differences in the expression of hepatic lipid processing genes in mice. [PDF]

PLoS ONE, 2013
Many hepatic functions including lipid metabolism, drug metabolism, and inflammatory responses are regulated in a sex-specific manner due to distinct patterns of hepatic gene expression between males and females.
Astrid Kosters, Deqiang Sun, Hao Wu, Feng Tian, Julio C Felix, Wei Li, Saul J Karpen   +6 more
doaj   +4 more sources

Transcriptional control of nucleus accumbens neuronal excitability by retinoid X receptor alpha tunes sensitivity to drug rewards. [PDF]

Neuron, 2023
ABSTRACTThe complex nature of the transcriptional networks underlying addictive behaviors suggests intricate cooperation between diverse gene regulation mechanisms that go beyond canonical activity-dependent pathways. Here we implicate in this process a novel nuclear receptor transcription factor, Retinoid X Receptor Alpha (RXRα), which we identified ...
Godino A, Salery M, Durand-de Cuttoli R, Estill MS, Holt LM, Futamura R, Browne CJ, Mews P, Hamilton PJ, Neve RL, Shen L, Russo SJ, Nestler EJ.   +12 more
europepmc   +5 more sources

Date palm seed extract and herbal mixture mitigate gentamicin-induced renal injury in mice: Role of Protease-activated receptors (PARs) and Retinoid X receptor alpha (RXR-α) [PDF]

Journal of HerbMed Pharmacology, 2022
Introduction: Gentamicin (Gen) causes renal toxicity by inhibiting protein synthesis in kidney cells, causing proximal tubule cell necrosis and renal failure. Herein, we examined the nephroprotective effect of date palm seed extract (DPSE) and one herbal
Suliman Sohaim, Salman Mohammed, Elham Amin, Hussein M Ali, Mohamed Abdelbakky   +4 more
doaj   +2 more sources

Aβ and tau clearance through aerobic exercise: unveiling the β2-adrenergic receptor’s role in regulating autophagy-lysosomal pathways [PDF]

Autophagy Reports
The systematic dissection of molecular mechanisms through which aerobic exercise (AE) mitigates neurodegenerative pathologies remains a significant challenge.
Liu Yang, Haitao Yu, Gao-Shang Chai
doaj   +2 more sources

Inhibition of Carrageenan-Induced Cutaneous Inflammation by PPAR Agonists Is Dependent on Hepatocyte-Specific Retinoid X Receptor Alpha [PDF]

PPAR Research, 2006
It has been proposed that PPAR-dependent, accelerated catabolism of proinflammatory mediators may contribute to the fast resolution of inflammation. Because retinoid X receptors are obligate heterodimer partners of PPARs, we investigated the impact of ...
Yu-Jui Yvonne Wan, Mostafa Z. Badr
doaj   +2 more sources

Proximal Tubule-Specific Genetic Deficiency of PPARα Worsens Systemic Lipid and Glucose Metabolism During Fasting. [PDF]

FASEB J
Proximal tubule‐specific PPARα knockout mouse (PPARαΔKPT) showed decreased lipid and glucose metabolism in the kidney during fasting. Metabolism in the other organs was increased, presumably as a means of compensating for the impaired kidney metabolism.
Aomura D, Nimura T, Yamaka K, Yamada Y, Harada M, Nakajima T, Kimura T, Hashimoto K, Kanno H, Yanagita M, Gonzalez FJ, Tanaka N, Kamijo Y.   +12 more
europepmc   +2 more sources