Results 91 to 100 of about 25,727 (222)

The Integration of Epistasis Network and Functional Interactions in a GWAS Implicates RXR Pathway Genes in the Immune Response to Smallpox Vaccine.

PLoS ONE, 2016
Although many diseases and traits show large heritability, few genetic variants have been found to strongly separate phenotype groups by genotype. Complex regulatory networks of variants and expression of multiple genes lead to small individual-variant ...
Brett A McKinney, Caleb Lareau, Ann L Oberg, Richard B Kennedy, Inna G Ovsyannikova, Gregory A Poland   +5 more
doaj   +1 more source

The Evolving Landscape of Immunotoxicity: Charting Mechanisms and Future Strategies for Immune Checkpoint Inhibitor Adverse Events

Med Research, EarlyView.
ABSTRACT The use of immune checkpoint inhibitors (ICIs) has significantly improved the efficacy of cancer therapy, but their associated immune‐related adverse events (irAEs) can severely compromise treatment safety. This review systematically summarizes the core mechanisms underlying irAEs, which include multi‐organ damage resulting from T‐cell ...
Anqi Lin, Keyin Zheng, Aimin Jiang, Xufeng Huang, Qi Wang, András Hajdu, Zhengrui Li, Jian Zhang, Peng Luo   +8 more
wiley   +1 more source

Chemoproteomic profiling reveals cellular targets of nitro-fatty acids

Redox Biology, 2021
Nitro-fatty acids are a class of endogenous electrophilic lipid mediators with anti-inflammatory and cytoprotective effects in a wide range of inflammatory and fibrotic disease models.
Ming-Yu Fang, Kuan-Hsun Huang, Wei-Ju Tu, Yi-Ting Chen, Pei-Yun Pan, Wan-Chi Hsiao, Yi-Yu Ke, Lun K. Tsou, Mingzi M. Zhang   +8 more
doaj  

Genetic characterisation of PPARG, CEBPA and RXRA, and their influence on meat quality traits in cattle

Journal of Animal Science and Technology, 2016
Background Peroxisome proliferator-activated receptor gamma (PPARG), CCAAT/enhancer binding protein alpha (CEBPA) and retinoid X receptor alpha (RXRA) are nuclear transcription factors that play important roles in regulation of adipogenesis and fat ...
Daniel Estanislao Goszczynski, Juliana Papaleo Mazzucco, María Verónica Ripoli, Edgardo Leopoldo Villarreal, Andrés Rogberg-Muñoz, Carlos Alberto Mezzadra, Lilia Magdalena Melucci, Guillermo Giovambattista   +7 more
doaj   +1 more source

Transcriptomic profiling of PBDE-exposed HepaRG cells unveils critical lncRNA- PCG pairs involved in intermediary metabolism.

PLoS ONE, 2020
Polybrominated diphenyl ethers (PBDEs) were formally used as flame-retardants and are chemically stable, lipophlic persistent organic pollutants which are known to bioaccumulate in humans.
Angela Zhang, Cindy Yanfei Li, Edward J Kelly, Lianne Sheppard, Julia Yue Cui   +4 more
doaj   +1 more source

Association of VDBP rs4701 variant, but not VDR/RXR-α over-expression with bone mineral density in pediatric β-Thalassemia patients

Mediterranean Journal of Hematology and Infectious Diseases, 2020
Introduction: The reduced rate of bone formation despite the availability of vitamin D has been reported in β-thalassemia.  This suggests genetic factors together with environmental one can be implicated in this condition. Since vitamin D binding protein
Shaimaa Sahmoud, Mostafa Ibrahim, Eman Toraih, Noha Kamel, Manal Fawzy, Samar Elfiky   +5 more
doaj   +1 more source

Genetic Polymorphisms in Vitamin D Metabolism and Signaling Genes and Risk of Breast Cancer: A Nested Case-Control Study. [PDF]

PLoS ONE, 2015
Genetic polymorphisms in vitamin D metabolism and signaling genes have been inconsistently associated with risk of breast cancer, though few studies have examined SNPs in vitamin D-related genes other than the vitamin D receptor (VDR) gene and ...
Tess V Clendenen, Wenzhen Ge, Karen L Koenig, Tomas Axelsson, Mengling Liu, Yelena Afanasyeva, Anne Andersson, Alan A Arslan, Yu Chen, Göran Hallmans, Per Lenner, Tomas Kirchhoff, Eva Lundin, Roy E Shore, Malin Sund, Anne Zeleniuch-Jacquotte   +15 more
doaj   +1 more source

Ferroptosis in Pneumoconiosis: From Molecular and Cellular Mechanisms to Therapeutic Strategies

Med Research, EarlyView.
Targeting lung various cells to alleviate pneumoconiosis by suppressing ferroptosis. AAV9‐HGF, adeno‐associated virus‐hepatocyte growth factor; DFP, deferiprone; DHQ, dihydroquercetin; Fer‐1, ferrostatin‐1; IL‐1β, interleukin‐1β; NMN, nicotinamide mononucleotide; sh‐SLC39A14, shRNA targeting solute carrier family 39 member 14; si‐OC‐STAMP, siRNA ...
Mengli Yan, Jing Zhang, Gaili Ji, Xiaobin Fang, Chunheng Mo   +4 more
wiley   +1 more source

Integrated transcriptomic and epigenomic analysis of primary human lung epithelial cell differentiation. [PDF]

PLoS Genetics, 2013
Elucidation of the epigenetic basis for cell-type specific gene regulation is key to gaining a full understanding of how the distinct phenotypes of differentiated cells are achieved and maintained.
Crystal N Marconett, Beiyun Zhou, Megan E Rieger, Suhaida A Selamat, Mickael Dubourd, Xiaohui Fang, Sean K Lynch, Theresa Ryan Stueve, Kimberly D Siegmund, Benjamin P Berman, Zea Borok, Ite A Laird-Offringa   +11 more
doaj   +1 more source

PPARγ Agonistic Activity of Mimulone and Diplacone Encapsulated in Liposomes and Cyclodextrin Complexes

ChemistryOpen, EarlyView.
Encapsulation of the geranylated flavanones mimulone and diplacone in hydroxypropyl‐β‐cyclodextrins (HP‐β‐CDs) and liposomes is evaluated for their peroxisome proliferator‐activated receptor gamma agonistic activity. While liposomes reduce efficacy, HP‐β‐CDs preserve up to 91.5% of mimulone's activity and mitigate diplacone's cytotoxicity, highlighting
Daniela Nykodýmová, Lenka Molčanová, Jan Kotouček, Josef Mašek, Jakub Treml   +4 more
wiley   +1 more source