Results 101 to 110 of about 25,727 (222)

Emerging Nanonutraceuticals against Obesity

Small Science, EarlyView.
This overview comprehensively compiles the latest research advancements in diversiform nanonutraceuticals against obesity. These nanonutraceuticals are derived from the nanomodifications of some carbohydrates, lipids, proteins, vitamins, minerals, and phytochemicals.
Linjie Ni, Minmin Peng, Yiying Liang, Xiwen Ye, Hanying Zheng, Dongbei Guo, Liang Yang, Xusangni Li, Ronghe Chen   +8 more
wiley   +1 more source

Astrocyte Lipid Droplet Dynamics Orchestrate Neurological Disorders and Therapeutic Horizons

Small Science, EarlyView.
This review examines astrocyte lipid droplet (LD) metabolism in neurological disorders, including Alzheimer's disease, stroke, epilepsy, and glioma. It analyzes regulatory mechanisms governing LD formation, transport, and degradation in astrocytes, highlighting their potential as biomarkers and therapeutic targets through integrative multiomics ...
Jiani Zhong, Yanyi Peng, Lingyue Zhang, Bo Xiao, Mengqi Zhang   +4 more
wiley   +1 more source

Cytochrome P450 genes are differentially expressed in female and male hepatocyte retinoid X receptor alpha-deficient mice.

Endocrinology, 2003
To study the functional role of retinoid X receptor alpha (RXRalpha) in hepatocytes, hepatocyte RXRalpha-deficient mice have been established. Characterization has been performed on male mice. In this paper, we show that the expression of CYP450 genes is
Yan Cai, T. Dai, Y. Ao, T. Konishi, Kuang-Hsiang Chuang, Y. Lue, Chawnshang Chang, Y. Wan   +7 more
semanticscholar   +1 more source

Sevoflurane induces the inattention, cognitive impairment, and motor dysfunction by hypermethylation of retinoic acid receptor α in the medial prefrontal cortex of neonatal mice

VIEW, EarlyView.
The mechanisms underlying neurodevelopmental toxicity induced by repeated exposure to general anesthesia in neonatal mice remain to be fully elucidated. In this study, neonatal mice were exposed to sevoflurane on postnatal days 6, 8, and 10. On postnatal day 30, the medial prefrontal cortex was collected for whole‐genome bisulfite sequencing and RNA ...
Yu Hou, Shuai Li, Qi Hou, Runjia Wang, Zhenghao Deng, Xiyuan Xu, Zhichao Li, Linhui Ma, Yuan Shen, Qidong Liu, Hui Zheng   +10 more
wiley   +1 more source

Aerobic Exercise Attenuates Autophagy‐Lysosomal Flux Deficits via β2‐AR‐Mediated ESCRT‐III Subunit CHMP4B in Mice With Human MAPT P301L

Aging Cell, EarlyView.
MAPT accumulation inhibited CHMP4B expression and thus disrupted ESCRT‐III‐mediated autophagosome‐lysosome fusion, which induced a vicious cycle between MAPT aggregation and autophagic deficits. Aerobic exercise could effectively block the vicious cycle and reverse autophagic deficits by promoting the β2‐AR‐RXRα‐CHMP4B‐ESCRT‐III pathway, reducing ...
Shu‐Guang Bi, Haitao Yu, Tian‐Long Gao, Jia‐Jun Wu, Yu‐Ming Mao, Juan Gong, Fang‐Zhou Wang, Liu Yang, Jia Chen, Zi‐Chong Lan, Meng‐Ting Shen, Yun‐Juan Nie, Gao‐Shang Chai   +12 more
wiley   +1 more source

Foetal disruptive brain injuries: Diagnosing the underlying pathogenetic mechanisms with cranial ultrasonography

Developmental Medicine &Child Neurology, EarlyView.
Abstract Antenatal destructive events affecting the central nervous system of the foetus lead to disruptive brain lesions that are often associated with impaired neurodevelopment. The pathogenesis of these lesions encompasses a range of causes, including haemorrhagic, embolic, or other vascular events; exposure to teratogens, such as drugs or substance
Ana Alarcón, Nuria Carreras, Tobias Muehlbacher, Dídac Casas‐Alba, Roberta Arena, Paola Roca‐Llabrés, Juan Navarro‐Morón, Linda S. de Vries, Paul Govaert, the EurUS.Brain group, Thais Agut, Roberta Arena, Ana Alarcón, Juan Arnáez, Marco Bartocci, Isabel Benavente‐Fernández, María Carmen Bravo, Fernando Cabañas, Nuria Carreras, Olivier Claris, Jeroen Dudink, Monica Fumagalli, Alfredo García‐Alix, Paul Govaert, Sandra Horsch, Simón Lubián, Tobias Muehlbacher, Alessandro Parodi, Adelina Pellicer, Luca Ramenghi, Charles C. Roehr, Simone Schwarz, Sylke Steggerda, Eva Valverde   +33 more
wiley   +1 more source

Synovial fluid alpha‐2‐macroglobulin, gelsolin and lubricin distinguish between osteoarthritic and healthy equine joints

Equine Veterinary Journal, EarlyView.
Abstract Background Synovial fluid (SF) is an ideal sentinel fluid for osteoarthritis (OA) diagnosis and prognostication due to its critical homeostatic role, proximity to articular tissues and immune cell composition. Untargeted proteomics enable identification of soluble markers for diagnostic and therapeutic applications while minimising bias ...
Erica J. Secor, Sydney J. Womack, Machiel P. Ysebaert, Marshall J. Colville, Heidi L. Reesink   +4 more
wiley   +1 more source

The Roles and Clinical Significance of Major Hepatic‐Derived Metabolites in Hepatocellular Carcinoma

Journal of Gastroenterology and Hepatology, EarlyView.
ABSTRACT Hepatocellular carcinoma (HCC) is increasingly recognized as a metabolically orchestrated malignancy, in which hepatic‐derived metabolites function not only as byproducts of liver physiology but also as active modulators of tumor biology.
Rui Sun, Xiaoru Wang, Jiayi Ma, Yuying Cai, Lei Li, Shanshan Wang   +5 more
wiley   +1 more source

Systemic, Lifestyle and Environmental Modifying Factors in the Pathogenesis of Periodontitis

Journal of Periodontal Research, EarlyView.
A variety of impacting factors in the pathogenesis of periodontitis exist, including systemic, lifestyle, and environmental factors. This review highlights the manifold mechanistic aspects of the link between the pathogenesis of periodontitis, addressing these numerous factors to supplement the long‐standing knowledge of the progression of the disease.
Groeger Sabine Elisabeth, Zhou Yuxi, Yong Jiawen, Wang Lei, Ruf Sabine, Meyle Joerg   +5 more
wiley   +1 more source

Classical Juvenile Pityriasis Rubra Pilaris Treated With Secukinumab: Case Report and a Review of Biological Treatments in the Pediatric Population

Pediatric Dermatology, EarlyView.
ABSTRACT Pityriasis rubra pilaris (PRP) is a rare, chronic papulosquamous disorder with limited treatment options in pediatric patients. We report the case of a 9‐year‐old boy with juvenile PRP (type III), who achieved complete disease remission after treatment with secukinumab, an IL‐17A inhibitor, following initial therapeutic resistance to topical ...
Zeno Fratton, Giuseppe Stinco, Enzo Errichetti   +2 more
wiley   +1 more source